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SternLab @sternadi.bsky.social
@SternLab
Studying the evolution of viruses, microbes, their hosts and beyond at Tel-Aviv University.
Israel
Joined June 2017
Posts
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    Millions of SARS-CoV-2 seqs out there..what info do they hide? Combining phylogeny & deep learning we infer hundreds of chronic infections & show they predict future evolution. Want to know how? ๐Ÿงต biorxiv.org/cgi/content/shโ€ฆ @SheriHarari @Daniellemlrs @shay_fleishon @BursteinLab
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    In Israel, real-world evidence on VOCs and vaccine protection: Mainly, B.1.351 enriched in infected vaccinated individuals, but this is offset by lack of ability of this variant to spread. medrxiv.org/content/10.110โ€ฆ @taliakustin @NoamHarel8 @RanBalicer @TelAvivUni More details:
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    Replying to @SternLab
    6. We think that this reduced effectiveness occurs only in a short window of time (no B.1.351 cases 14+ days post 2nd dose), and that the S.A. variant does not spread efficiently. Thus, even more of a reason to get vaccinated and drive down cases to zero!
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    My brilliant PhD student Nufar, whose brother is a hostage in Gaza for over 80 days. Nothing prepared me to being a mentor under such a scenario. How can we even continue research in the lab?? Please help her, help us, spread this heart-breaking humanitarian call.
    00:00
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    Replying to @SternLab
    5. To summarize: we see evidence for reduced vaccine effectiveness against the British variant, but after two doses โ€“ extremely high effectiveness kicks in. We see evidence for reduced vaccine effectiveness against the S.A. variant, but it does not spread in Israel.
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    Finally excited to share our work with @KoelleLab @m_a_martin and many others on features of SARS-CoV-2 spread. medrxiv.org/content/10.110โ€ฆ What did we find: 1. Sequenced 212 genomes from Israel @GISAID @nextstrain
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    Please help me spread the story of two hostages, Yogev and Rimon. Yogev is the brother of my amazingly talented & modest Ph.D. student Nufar, whose life has become a nightmare since Oct. 7. giveback.co.il/project/75481 ynet.co.il/news/article/sโ€ฆ
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    Replying to @SternLab
    4. Furthermore, focusing on the partially immunized, we noted more breakthrough by the โ€œBritishโ€ variantโ€. We think this might explain why during the early stages of the vaccination rollout in Israel, it took a while till vaccination effects were noted and cases began to drop
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    So I am formally "tenured + professored " !!! โœจโœจโœจ
    GIF
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    Replying to @SternLab
    1. We wanted to test what type of variant infects the very few vaccinated individuals who go on to become infected with SARS-CoV-2. To this end, we generated a case-control cohort: every vaccinee was matched with a non-vaccinated individual infected with the virus
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    ืื ื™ ื”ื•ืœื›ืช ืœื”ืชื—ืกืŸ ื‘ืจื’ืข ืฉื™ืืคืฉืจื• ืœื™. ืœืžื”? 1. ื›ื“ื™ ืœื”ืžื ืข ืžืžื—ืœื” ืงืฉื” ื•ืœื ื ืขื™ืžื” ื›ื•ืœืœ ืชื•ืคืขื•ืช ืœื˜ื•ื•ื— ืืจื•ืš, 2. ื›ื™ ื™ืฉ ืกื™ื›ื•ื™ ื’ื‘ื•ื” ืœื“ืขืชื™ (ืœื ื ื‘ื“ืง ืขื“ื™ื™ืŸ ืื‘ืœ ื”ื’ื™ื•ื ื™ ื‘ื”ื ืชืŸ ื™ื“ืข ืงื•ื“ื) ืฉื›ื›ื” ืื’ืŸ ืขืœ ื”ืกื‘ื™ื‘ื” ืฉืœื™. 3. ืจื•ืฆื” ืœื—ื–ื•ืจ ืœื—ื™ื™ื ืคืจื” ื”ืขื™ื“ืŸ ื”ืžื˜ื•ืจืฃ ื”ื–ื”.
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    Replying to @SternLab
    3. All in all โ€“ most infections in both categories were from the โ€œBritishโ€ variant B.1.1.7. However, we noted 8 cases of infection with the โ€œS.Aโ€ variant B.1.351 in fully immunized individuals, as compared to only 1 infection in the control (non-immunized).
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    Nightmares. That my home will be invaded by terrorists. Nightmares & images I canโ€™t even put down in words. Nightmares of crowds jeering at kidnapped children. I walk around at night gazing at my children, wondering how to protect them from my nightmares that are also reality.
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    Replying to @SternLab
    2. Two categories interested us: (i) those fully immunized, 7+ days post the second dose of the Pfizer/BioNtech vaccine, (ii) those partially immunized, between 14+ days after the first dose and before 7 days after the second dose.