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Stephen Quake
@StephenQuake
Professor of #bioengineering and Applied Physics @stanford Prolific inventor at the nexus of #biology, #physics, and #tech
Joined March 2021
Posts
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    While on a lecture tour in Japan, I was able to divert to Hokkaido for a few days to ski their world-class powder snow. I've been skiing since I was six years old, and Niseko and Kiroro did not disappoint!
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    In @CellCellPress, I share a major conceptual challenge for biology in the next decade, inspired by Crick’s Central Dogma: understanding information flow in the cell, the smallest indivisible unit of life bit.ly/4hQMmva
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    In our study, we describe Smart-seq-total, an RNA-sequencing method that delivers a broad picture of the total cellular RNA content. Click here to learn more: bit.ly/3pVQ10I @alinaisakovaSci @PNASNews
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    Excited to share a new study in @nature led by @Wenfei_Sun and in collaboration with Thomas Sudhof’s lab that maps a memory engram. It shows the interplay of neurons and astrocytes in long-term memory formation. Congrats to the team for this work. bit.ly/3SyEUt3
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    Virtual cell models have the potential to transform biological research. Today @ChanZuckerberg released an initial set of models, including scGenePT and SubCell, designed to be easy to run and build upon. This is a really exciting time in biology.
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    Using #singlecell #transcriptomics, we created a molecularly defined phenotypic reference of human cell types spanning 24 human tissues and organs. bit.ly/3DlKg10 @biorxiv @czbiohub
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    "It may seem ridiculously naïve to characterize something with the complexity & intricacy of a cell as a ‘bag of RNA’. I will argue that in fact it is a powerful & productive abstraction that is helping revolutionize our understanding of cell biology." loom.ly/tXlvMF8
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    The Tabula Sapiens maps nearly 500,000 cells from 24 tissues and organs. A great accomplishment for #singlecell biology in redefining how we understand human biology. Congrats team, @czbiohub. @ScienceMagazine
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    Our Tabula Muris team set out to determine the cell types and molecular pathways which can be rejuvenated by parabiosis - an effort to reverse aging. nature.com/articles/s4158…
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    Why I refer to the cell as a "bag of RNA" in my @sciencedirect article: loom.ly/tXlvMF8 #cellbiology #mRNA
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    It has been an exciting first week as @chanzuckerberg’s Head of Science. It has been great to meet the team and I am looking forward to all that is to come in this new role.
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    One of my hobbies outside of my work in science is reading. Here are a few of the top books I read last year. What were some of your favorite books you read in 2022?
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    I’m thrilled to see this group of distinguished scientists come together to launch the @ChanZuckerberg Imaging Institute and build a new generation of electron microscopy technologies that will advance our understanding of human biology czi.co/3cHItLU
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    Excited to share that @AllenInstitute, @cziscience and @UWMedicine are joining forces to launch the Seattle Hub for Synthetic Biology. Led by Jay Shendure, the Seattle Hub aims to revolutionize how we understand cell history and gene functions czi.co/SeaSynBioLaunch #SeaSynBio