SnapShot: Bacterial Immunity
@Nitzan_T masterfully organized current knowledge on bacterial immune systems into a single page graphics
Out today @CellCellPress : cell.com/cell/fulltext/…
Sorek Lab
1,115 posts
Sorek Lab
@SorekLab
The Sorek Lab
- Bacterial origins of human innate immune mechanisms Tanita Wein skillfully summarized current knowledge on how key components our own immune system evolved from bacterial anti-phage defenses Out today in Nature Reviews Immunology rdcu.be/cKWrz
- Preprint: We report the discovery of >20 new bacterial defense systems! Some with homology to human immune genes A 4-year effort of the entire Sorek Lab, led by talented @AdiMillman, @Curiousphage, Azita Leavitt, @shany_doron and many more
- After more than three decades of mystery, we are happy to report that we discovered the function of some of the coolest bacterial elements - retrons. Retrons function as anti-phage defense systems! See our new preprint biorxiv.org/cgi/content/sh… @AdiMillman @AudeBer @AAvihail
- On the origin of immunity Remarkable similarities between human and bacterial immune systems. Cyclic GMP–AMP signalling protects bacteria against viral infection nature.com/articles/s4158… Congrats CBASS team! Daniel Cohen @AdiMillman @GilAmitai @shany_doron #cGAS-#STING
- Happy to see our paper out @Nature: Phages confiscate signaling molecules produced by immune TIR proteins to cancel host immunity Structure of anti-defense "sponge" protein reveals a new class of antiviral signaling molecules: glycocyclic-ADPR (gcADPR) nature.com/articles/s4158…
- Happy to share our paper out today @nature: TIR domains in bacteria protect from viruses by producing unique signaling molecules A surprising parallel between bacterial and plant immunity Congrats @gaofir, @GilAmitai and coauthors! tinyurl.com/TirOfir
- Our paper out today @Nature: phages reconstitute NAD+ to counter bacterial immunity Phaged invented a new biochemical pathway for NAD+ synthesis - including previously unknown enzymatic reactions - to evade bacterial defenses Congrats @IlyaOsterman! nature.com/articles/s4158…
- If Antoine de Saint-Exupéry was a microbiologist... Best farewell gift ever, from @Curiousphage
- New in Nature: The evolutionary origin of the human STING protein is the bacterial CBASS anti-phage system. "STING cyclic dinucleotide sensing originated in bacteria" nature.com/articles/s4158…
- Happy to see our paper out @Nature today: A bacterial immune system conjugates ubiquitin-like proteins to phage tails. This generates non-infective virions Congrats @Jens_Hoer & @ShaLGW! Link to paper: tinyurl.com/Isg15 Read the thread: x.com/SorekLab/statu…
Proud to share our latest discovery: Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly A new concept in antiphage immunity, and a mechanism for ISG15-like antiviral defnese in bacteria. Big congrats to talented @Jens_Hoer! A 🧵 biorxiv.org/content/10.110… - Out @CellCellPress: Together with the Kranzusch lab, we characterized RADAR, a giant immune machine that blocks viruses via adenine deamination A complex of 96 protein subunits, 4 times heavier than the ribosome Congrats @B_DuncanLowey and @Nitzan_T! tinyurl.com/Trcfr
- A family of bacterial enzymes produce antiviral molecules to fight phage! These enzymes form the origin of Viperin, an important human antiviral gene. Check out our new paper: nature.com/articles/s4158…
- These kind of discoveries remind us all why we fell in love with biology and decided to make it our professionMy favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/
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