Sohail Tavazoie (@SohailTavazoie) / X

Sohail Tavazoie

316 posts

Sohail Tavazoie

@SohailTavazoie

Cancer & RNA biologist, Oncologist,New Yorker

New York City

Joined June 2009

Sohail Tavazoie
@SohailTavazoie
Sep 30, 2020
Ever wondered about how cancer cells escape the primary tumor to metastasize? Proud of @BernardoTavora & crew, who uncovered the most unexpected mechanism just out in Nature rdcu.be/b7UPq …..let me break it down [thread] 1/n
Rockefeller University
@RockefellerUniv
Sep 30, 2020
New research from @SohailTavazoie in @nature suggests that breast and lung tumors metastasize by hijacking a neural signaling pathway, potentially opening the door to better diagnostics and treatments. #RockefellerScience rockefeller.edu/news/29254-can…
Sohail Tavazoie
@SohailTavazoie
Jan 7, 2023
How does Codon bias emerge? @DennisJHsu shows: limiting arginine causes arginine codon switching mutations in cancer: Low Arg aa-> reduced Arg tRNA->ribosome pausing->proteomic shift->DNA evolution. big thx to @s_tavazoie @columbia @rockefeller
science.org
Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal...
Extracellular arginine limitation causes mutation away from arginine codons and favors low-arginine protein translation.
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Sohail Tavazoie
@SohailTavazoie
Oct 17, 2022
Honored for election to @theNamedicine for discoveries by my brilliant students & postdocs, sacrifices by my loving parents, support from amazing sibs @s_tavazoie, Masoud & Sima, inspiring @rockefeller colleagues and above all my amazing partner Isabela!! @the_asci @theNCI
National Academy of Medicine
@theNAMedicine
Oct 17, 2022
Congratulations and welcome to the 100 new members elected today to the National Academy of Medicine! #NAMmtg nam.edu/national-acade…
Sohail Tavazoie
@SohailTavazoie
May 25, 2020
1/ Congrats to Ben Ostendorf and our #TavazoieLab at @RockefellerUniv for revealing a hereditary genetic basis to cancer metastasis and survival. The “Alzheimer’s gene” APOE modulates melanoma outcome - our paper out today in @NatureMedicine nature.com/articles/s4159…
Sohail Tavazoie
@SohailTavazoie
Oct 8, 2023
Fellow 2022 class inductee @kkariko takes our @theNAMedicine ceremony to the next level :O
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Sohail Tavazoie
@SohailTavazoie
Oct 23, 2023
Transfer RNAs (tRNAs) are increasingly found to play dynamic and critical regulatory roles in cancer progression. Alexandra Pinzaru's review describes this exciting area of research: nature.com/articles/s4156…
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Sohail Tavazoie
@SohailTavazoie
Aug 7, 2024
The amazing @VeenaPadmanaban & co show in @Nature that sensory neurons drive breast cancer metastasis via neural activity-based paracrine signaling where neural Substance-P drives ssRNA release/TLR7 signaling @RockefellerUniv @theNCIsysbio @BCRFcure
Veena Padmanaban
@VeenaPadmanaban
Aug 7, 2024
🚨❗️🚨 New Paper Alert My postdoctoral work now out in @Nature. We find that sensory neurons drive breast cancer metastasis via an activity-dependent paracrine signalling mechanism mediated by substance-P, extracellular ssRNA & TLR7 receptor. (1/11) urldefense.com/v3/__https://w…$ 🧵👇🏾
Neuronal substance P drives metastasis through an extracellular RNA–TLR7 axis
From nature.com
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Sohail Tavazoie
@SohailTavazoie
Mar 14, 2022
Translation typically promotes tumorigenesis. The amazing @mpassarelli15 with @genophoria & crew show that deleting a copy of Leucyl tRNA synthetase gene drives breast tumorigenesis via codon-dependent translation modulation tweetorial by MP. nature.com/articles/s4155…… @triimdphd
Sohail Tavazoie
@SohailTavazoie
Oct 7, 2021
Isabel Kurth, Nori Yamaguchi, Celia Andreu-agullo and Masoud Tavazoie show that therapeutic inhibition of SLC6a8 creatine transporter by RGX-202 inhibits colon cancer progression/metastasis & modulates human creatine metabolism.
science.org
Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and...
RGX-202, a small-molecule creatine transporter SLC6A8 inhibitor, suppresses colorectal cancer and modulates human creatine levels.
Sohail Tavazoie
@SohailTavazoie
Oct 14, 2021
Congrats on an outstanding defense @mpassarelli15. We will miss your intellect, perseverance, optimism, smile and love of RNA. Enjoy your clinical training as you navigate your physician-scientist path. Your future is very bright! @TriIMDPhD @RockefellerUniv
Sohail Tavazoie
@SohailTavazoie
Dec 12, 2022
The amazing @TriIMDPhD student Lisa Earnest-Noble's paper is out showing that two so called 'synonymous' isoleucyl tRNAs opposingly regulate breast cancer & metastasis by driving distinct gene regulatory programs. @RockefellerUniv also thx to @genophoria nature.com/articles/s4301…
Sohail Tavazoie
@SohailTavazoie
Dec 9, 2024
A commonly inherited genetic variant of human PCSK9 drives breast cancer metastasis and associates with reduced patient survival. @CellCellPress PCSK9 drives pro-metastatic genes by repressing LRP1. Anti-PCSK9 antibody has breast CA metastasis suppressive effects
Wenbin Mei
@wenbin_mei
Dec 9, 2024
EXCITED to share my PhD work in @CellCellPress. We found that the chance of developing metastasis is partly decided by the DNA we inherited. We identified a germline variant in PCSK9 present in 70% of the white women conferring higher risk of breast cancer metastasis. (1/9)
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Sohail Tavazoie
@SohailTavazoie
Oct 7, 2024
The greatest story of fearless scientific discovery by two of the most creative, supportive, and kind scientists on the planet !!
The Nobel Prize
@NobelPrize
Oct 7, 2024
BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
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Sohail Tavazoie
@SohailTavazoie
Dec 29, 2023
Congrats to amazing @AlonMillet and Jose Ledo on discovering an exhausted-like microglial population that accumulates in aged and APOE4 @Alzheimers brains of humans and mice and is defective in amyloid clearance @RockefellerUniv
Alon Millet
@AlonMillet
Dec 29, 2023
Thrilled to cap off the year with the first paper of my PhD, out today in @ImmunityCP! We describe a population of exhausted-like microglia that accumulate in #Alzheimer's in both humans and mice in an age- and APOE4-dependent manner authors.elsevier.com/c/1iL2Z3qNrUu4… Tweetorial below🧵
An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains
From cell.com
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