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1/4 A Perspective on proximity-inducing #molecularglues and bifunctional compounds in relation to hot-spot-associated missense mutations enshrined by natural selection and posttranslational modifications (PTMs). chemrxiv.org/engage/chemrxi…
Stuart Schreiber
745 posts
Stuart Schreiber
@SchreiberStuart
Truth-seeking scientist; equal parts Cajun, Mississippian, Irish, Hungarian.
Boston, MA
Joined August 2018
- Without love and encouragement from my wife Mimi, this would have remained a personal diary for the two of us. The response from so many of you has warmed my heart. I am profoundly grateful.
- On behalf of his loving family, and with a heavy heart, I’m sad to report the passing of Yoshito Kishi, a towering figure in organic chemistry. In addition to his transformative research, Yoshi will be forever remembered for his warmth, generosity, and deep sense of humanity.
- 1/2. Molecular glues, with and without linkers, are being used to stabilize, degrade, alter cellular locations and bind otherwise featureless therapeutic targets. (Images by @moscienceart)
- In our open letter, we scientists are standing up for @Harvard professor Charles Lieber. We also are speaking out against the harm that the prosecution of Charles and other scientists has inflicted on academic freedom and scholarly collaboration.
- 1/11. Molecular glues and bifunctional compounds induce neo-protein associations with target proteins and neo-substrate interactions with enzymes.
- This is synthetic biology at its best – from the Pete Schultz lab at Scripps. Having made a bacterium with non-natural cross links in its cell wall, the role of this biophysical feature can now be explored in highly novel ways.
- 40 years to the day when the most remarkable and impacting event of my life occurred. Mimi and I were married. ❤️
- Next time drug-hunter gurus tell you your idea won't work because your target is essential, have them look up this paper relating successful drug targets to "human knock-out" genes, among others. Great work by @EricMinikel and team. nature.com/articles/s4158…
- Today, humanity has a big aching hole in its heart. We lost a giant – Bob Williams, organic chemist extraordinaire, super-dad to his kids, loving husband to his wife and mentor to many. Bob was my mentor in life. I loved him and loved telling him so.
- 1/N. Missing, but mostly appreciating, Dave Evans (Jan 11, 1941-Apr 29, 2022). I'd like to share one remembrance. Dave was fond of saying that his first chemistry meeting in June 13-17, 1965 "changed my life". Judging from the speakers, you can easily imagine why.
- On the heels of the repurposing of FKBP12-rapamycin with a novel synthetic molecular glue (left), we now have the repurposing of cyclophilin–CsA (center) to target KRAS G12C with another synthetic glue (right) science.org/doi/10.1126/sc…
- Half-way through my doctoral studies when my adviser passed suddenly and unexpectedly, I was rescued by a generous and outstanding mentor Yoshi Kishi. It kept me grounded and changed my life. We should all be prepared to pay forward.When a lab shuts down in the middle of your training, it can feel like the end of your career. I'm forever grateful to my mentors who were there for me in the most concrete ways. I wish trainees hit by today's news the same support and care and that they, too, land on their feet.
- 1/4. Molecular glues and bifunctional compounds induce protein–protein associations. In open-source collaboration with Novartis, we first used DEL screening to discover bifunctional compounds in one step using preselected presenter and target proteins nature.com/articles/s4158…
