What limits rubisco function? Is it the chemical mechanism? Evolution? In an updated pre-print @prywes et. al explore this question by assaying >99% of single amino acid mutants in Form II rubisco (1/7)
Savage Lab
1,137 posts
Savage Lab
@SavageCatsOnly
Compartmentalizing your metabolism, and y’know, CRISPR stuff. Account managed by grad students and postdocs 🤙 @UCBerkeley @berkeleyMCB @igisci @HHMINEWS
- From our lab to yours, Happy Halloween! May your 260/280 always be ~1.8 and your 260/230 fall within 2.0-2.2 🎃🧬🧪 @QIAGEN
- 🚨 New pre-print! We engineered catalytically inactive and improved #Cas13 effectors for efficient post-transcriptional regulation of genes in bacteria and human cells. 1/5
- Former Amgen scholar @caroguerrero522 enjoyed her summer in the Savage lab so much she decided to come back for more. Excited to welcome this Savage Cat back to the lab as a grad student!
Check out our new @biorxivpreprint with @SavageCatsOnly on RuBisCO lattices in α-carboxysomes: doi.org/10.1101/2022.0…- Years in the making - a peroxidase-encapsulating nanocompartment helps M. TB survive oxidative stress in acidic environments including in hosts! Amazing collaboration between Katie Lien, @Nichols_NTA and Caleb CA, #SavageCats and Stanley Lab.
- Our new paper c/o first authors @realarikshams & Sean Higgins is LIVE !! We report on engineering minimal Cas9 enzymes for maximum impact 🧬✂️
- New work out from Savage Cats! “CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification” congrats to Ben, Christoff, Harneet, Kian, Rayka et al!!!! sciencedirect.com/science/articl…
- Please RT! We’re looking to hire a postdoc interested in CRISPR biochemistry with a focus on diagnostics! Interested candidates can DM this account or email [email protected] with a CV & cover letter.
- .@Nichols_NTA's paper on a novel prokaryotic nanocompartment is out on @eLife 🤙! Check out the final version of Rob's thesis research on #encapsulins and #cyanobacteria below 👇 Special thanks to our amazing collaborators @bjlafrance and @NogalesLab!
Congrats to MCB's David Savage @SavageCatsOnly on his promotion to Professor of Biochemistry, Biophysics and Structural Biology! 👏🥂 mcb.berkeley.edu/news-and-event…- Like and RT this tweet to congratulate Savage Cat @BW_Thornton for passing her qualifying exam and ascending to PhD Candidate! @berkeleyMCB 🥳
- Our #preprint on MISER, a new technique for minimizing proteins is up on @biorxivpreprint! Tweetsplainer thread by @realarikshams below, including some neat insights on #CRISPR-Cas9 ⬇️
