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Ralser Lab
@RalserLab
Joined August 2013
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    We managed our first rejection from biorxiv.
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    Did you know that 28 out of 34 signalling pathways, and ~60% of the proteome, respond differently depending on the metal ion environment? Neither did we, but now believe that the metal ion levels are one of the big "known unknowns" in cellular networks
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    We have established our new proteomics platform developed @TheCrick, @ChariteBerlin for profiling #COVID19 patients. We found 27 biomarkers that distinguish mild from severe COVID19 according to @WHO criteria. Tremendous thanks to all who contributed!
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    We very much need to do something for postdocs and junior PIs that had young kids during the pandemic. I'm worried that once it is over, we all will forget quickly, but their CVs will not compete with those of others for a long time @ERC_Research @wellcometrust
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    Did you know that cells that share metabolites live longer? We didn't, and indeed I lost a beer betting with @CorreiaMeloC :-) Though, observing it was the easy part, but we wanted to know why. 6 yrs later, we have some answers. Read our paper in Cell authors.elsevier.com/sd/article/S00…
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    Want to learn how to do proteomes in less than a minute? We are looking for a postdoctoral scientist in mass spectrometry/biological analytics to join us charite.de/service/stelle… To support parents with small children, its possible to set this up as 4 days/week position
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    Admittedly, three things are true here 1) UK is a world leader in science, 2) it is a world leader in science, because so much foreign talent did in the past move to the UK and stayed in the UK 3) and that's exactly why 1) is now put at risk.
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    Experience after 15 years of peer reviewing: Already good papers get a little better, bad papers stay bad but get also published. Conclusion: we could take a much more light touch approach to peer review, and achieve the same result
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    Feeling nostalgic! tomorrow is our last day @TheCrick- Was privileged to supervise a brilliant team since 2013, 7 postdocs are now PIs, together we published just above 100 papers :-) Maybe the Crick accepts this tweet as a final report in exchange for having no tenure programme?
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    Interested in antimicrobial drug tolerance? We show that auxotrophs exist within virtually all microbial communities, and increase their drug tolerance by stimulating metabolic interactions. nature.com/articles/s4156…
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    authors.elsevier.com/sd/article/S24… Our Review about the History of Glycolysis research. 300 years and counting, and it's amazing how many fundamentals of Biology have been discovered studying glucose fermentation. It started with the desire to make better alcohol, btw :-)
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    We started a journey years ago to explain why all cells need polyamines. We still have no idea. But, we found a powerful but overlooked antioxidant mechanism: lysine harvesting. nature.com/articles/s4158…
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    Good things take good while (and can make your Friday :-) )
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    biorxiv.org/content/10.110… We have measured a proteome for a collection of 1,000 natural yeast isolates, and solve a long-standing debate. There is chromosome - wide dosage compensation in aneuploids!