Paraneoplastic neurological syndromes
Binks & @ANG_Oxford team describe how clinical and paraclinical features vary according to the rapidly expanding list of antibodies. Antibody-syndrome-tumour triad correlation is key to determining clinical relevance
bit.ly/3u6QDUL
Practical Neurology
1,882 posts
Practical Neurology - For the inquisitive neurologist
Joined December 2013
- Myorhythmia is a repetitive, rhythmic, slow movement affecting mainly the cranial and limb muscles. Stroke is the most common cause, but it can occur in the context of tumors, such as cervical spinal cord glioma bit.ly/3Hau851
00:00 - IgG4-RD - a rare neurological disease, highly responsive to treatment. Clinical awareness = early diagnosis = better clinical outcome @bristolneuroscience
- The Harlequin sign is characterised by striking hemifacial discoloration caused by asymmetrical flushing and sweating:
- SSEPs are a non-invasive tool that supports nerve conduction studies, detects proximal conduction issues, and aids diagnosis when imaging is limited.
- EEG plays a critical role in the diagnosis of status epilepticus and in teasing apart nonconvulsive status epileptics from encephalopathy.
- Remember Wernicke’s in pregnancy A 13-weeks pregnant woman develops confusion, drowsiness and diplopia after progressive nausea and vomiting. She improved rapidly following thiamine supplementation. @hospitalclinic @renuarturo pn.bmj.com/content/22/3/2…
- Looking at one’s hand for 30 s can elicit tingling sensations. This is helpful in explaining sensory gating to patients with functional symptoms.
- Autoimmune encephalitis is a rapidly emerging clinical entity often responding well to immunotherapies. @ANG_Oxford discuss clinical features, expand the autoantibody repertoire and offer pragmatic treatment advice pn.bmj.com/content/21/5/4… @encephalitis @NDCNOxford
- NMJ disorders have many mimics and unusual presentations. Awareness of key differentials and understanding limitations of tests are key to making the correct diagnosis. @clarefraser @WolfVucic
- Many myopathies have characteristic CK values that can help identify them, from normal or mildly elevated in facioscapulohumeral muscular dystrophy and myotonic dystrophy to exceeding 10 000 IU/L among dysferlinopathies. There are exceptions, including some myositis cases with
- Radiological features of MELAS include cortical ischaemia overlapping vascular territories, and cerebellar atrophy Stroke-like episodes in MELAS reflect seizures, rather than ischaemia, and can occur in people aged over 40 pn.bmj.com/content/22/3/2…
- DADA2 is a differential diagnosis of childhood PAN-like presentation (young stroke, dermatological manifestations and multiple mononeuropathies) Anti-TNF alpha agents are the best available treatment of choice @vishnuvy @AiimsNeurology @drayushagarwal pn.bmj.com/content/early/…























