Superman & the Powerpuff Girls are both entirely fictional cartoon characters so I say that the Powerpuff Girls can kill Superman simply because it's funnier if they win so take that
This was about how lame the show would be if it a was cliche girls show about teens hanging out instead of a superhero show. The clip cuts out the best part of the sequence which shows crimes and destruction going on in the background while the girls are distracted by the boys.
90s animation industry people: "Great now we can actually interact with our fans via message boards and fan conventions! Oh wait actually we hate these people."