Excited to be visiting @VirusesImmunity at the 2nd @YaleCII symposium today to talk about #LongCovid - Where we are, where we need to go, and how we can get there.
Michael Peluso, MD
88 posts
Michael Peluso, MD
@MichaelPelusoMD
- Our new #UCSF preprint showing prolonged tissue-level immune activation and gut viral persistence for up to 2 years post-COVID. Does COVID-19 induce a new immunologic set-point and how is this related to PASC/Long COVID? medrxiv.org/content/10.110…
- Our first @UCSF #LongCOVID clinical trial targeting viral persistence with monoclonal antibodies featured by @NanetteAsimov in the @sfchronicle today. I am grateful to @AeriumTx @patientled @polybioRF for supporting this effort.
- New @UCSF #LIINC paper: immune activation & viral persistence in tissue up to 2 years post-COVID. Found double-stranded RNA in #LongCOVID, suggesting active reservoir persists and evades immune clearance. Thanks @polybioRF, @NIH for support. @ScienceTM
- Today, the #Stanford #Paxlovid trial for #LongCOVID (STOP-PASC) reported no difference in patient reported outcomes between drug vs placebo. Headlines say it's "negative," some are saying we should abandon the virus persistence hypothesis. My take:
- Our new @UCSF #FindCOVID/#LIINC paper in @NatureComms showing SCV2 burden in first 3 weeks of COVID predicts future #LongCovid. In addition to LC treatment trials, we need investment in studies to prevent LC! Zero US-based trials on prevention so far. nature.com/articles/s4146…
- New #UCSF LIINC paper showing SARS-CoV-2-specific CD4 T cells with tissue homing markers and CD8 T cells with exhaustion. Dis-coordinated responses between antibodies and T cells. Also important differences in women. COVID Tissue persistence? biorxiv.org/content/10.110…
- Our mechanistic review of #LongCovid - published in @CellCellPress - hopefully will be helpful coming out of the very inspiring RECOVER-Treating Long COVID meeting this week. Excited for the progress we will make together in the next year! sciencedirect.com/science/articl…
- Proud to have been a part of this @polybioRF effort to describe the path forward for #LongCOVID trials targeting SARS-CoV-2 persistence. We need a robust biomarker development program and to launch more trials to rigorously test treatments that target these pathways now.BREAKING: Cutting-edge Recommendations Provide Treatment Path for Millions of Long COVID patients 💊 In a new report global experts outline key considerations to address persistent SARS-CoV-2; provide a roadmap to test critical new long COVID therapies: polybio.org/cutting-edge-r…
- @UCSF #LIINC study on SCV2 protein persistence up to 14 mon post-COVID in @TheLancetInfDis . Now need to study this systematically in larger cohorts to pin down what it means. Does it have consequences? #LongCOVID? Thanks @polybioRF @NIH for support
- I am proud to have signed onto this letter to President Biden asking him to address the crisis of #LongCovid and other infection-associated chronic conditions in his FY25 budget! We need a robust response now!Today a coalition of clinicians, researchers, RECOVER PIs, patient & disability orgs, and more sent an open letter to President Biden, urging him to address the crisis of #LongCovid & other infection-associated chronic conditions in his FY25 budget patientresearchcovid19.com/advocacy/lette… 1/
- Lots of attention on cortisol in #LongCovid lately. Here are results from a pilot project in the @UCSF #LIINC cohort. Similar levels between LC and recovered, but morning dynamics appear to differ, esp. in those with post-COVID ME/CFS. Detailed follow up project ongoing.
- The progress we have made on #LongCOVID so far is impressive. We need to keep it up. This means sustained investment in infection-associated chronic conditions research. @LisaAMcCorkell from @patientled and I wrote about this in @Nature today. nature.com/articles/d4158…
- Recent @UCSF #LIINC preprint finding SARS-CoV-2 antigen in plasma up to 14 months post-COVID. Samples prior to vaccine/reinfection. I now believe this is happening in at least some people. Major question - does this cause #LongCovid ? To be determined. medrxiv.org/content/10.110…
