Out in @Nature today, we report that #p53 loss unleashes an ordered & selective pattern of cancer #GenomeEvolution: nature.com/articles/s4158…. 1/n
Lowe Lab
250 posts
Lowe Lab
@LoweLabMSKCC
Our lab focuses on genetic changes in cancer and how they contribute to tumorigenesis in the hope of finding therapeutic targets. Tweets from Scott signed -SWL.
- Out in @Nature today, our latest work shows how tissue injury and Kras mutation cooperate to induce an epigenetic program that initiates pancreatic tumorigenesis. nature.com/articles/s4158… (1/3)
- Out in @Nature today, our latest work provides a proof of concept for the utility of #CART cells as #senolytics. This study was an exciting collaboration with the #SadelainLab... (1/3) nature.com/articles/s4158…
- My 2nd Spanish postdoc @AmaiaLujambio is an inspiring scientist & friend. With @KrizhanovskyLab, she revealed key links b/w senescence & tumorigenesis. She was a point person in our transition @CSHL ➡️ @MSKCancerCenter. So proud of her success at @IcahnMountSinai! –SWL #LoweLab25
- To mark 25 years (!!) since my first faculty appointment, I will be highlighting some of the fantastic Lowe lab trainees over the years, from its origins @CSHL to evolution @MSKCancerCenter. These are the people that made the Lowe lab what it is today. Stay tuned! –SWL #LoweLab25
- New Preprint! Led by #DynamicDuo @BarrigaFM & @KTsanov, this study set out to understand how somatic copy number alterations (CNAs) promote cancer. CNAs are prevalent across cancer types & correlate w/ clinical outcomes but remain difficult to study. 1/n
- My 2nd postdoc Marisol Soengas @msmelanoma helped establish a culture of drive & excellence in the lab @CSHL. After a successful tenure @UMich, she returned home to @CNIOStopCancer, where she is Head/Melanoma Group & VP @ASEICAnews. Check out her inspiring work! –SWL #LoweLab25
- First publication of 2024! Now out in @NatureCancer, the final (and substantially expanded) version of our work that develops a new suite of mouse models to study #MetastaticGastricCancer of customizable #Genotypes and #HostBackgrounds: nature.com/articles/s4301….
- What an incredible Reunion! It was wonderful to see all former lab members who traveled to NYC from all over the world & to experience the joy that we all shared in getting together. THANK YOU & stay in touch! #LoweLab25
- Join us as we congratulate our own Dr. Scott W. Lowe, who was just elected to the @theNAMedicine! Want to know more about Dr. Lowe's award-winning research? Follow us behind the scenes in his lab. @LoweLabMSKCC #NAMmtg bit.ly/2W4CrIX
- Out in @PNASNews today, we report new flexible mouse models of #OvarianCancer, and use them to gain insights into the role of #Senescence in chemo- & immunotherapy responses: pnas.org/content/119/5/….
- Now out in @NatureCancer, an updated version of our study developing the #MACHETE strategy for modeling large genomic deletions and using it to uncover a key role for type I #IFN deletions in tumor #ImmuneEvasion & #Metastasis: nature.com/articles/s4301… (1/3)New Preprint! Led by #DynamicDuo @BarrigaFM & @KTsanov, this study set out to understand how somatic copy number alterations (CNAs) promote cancer. CNAs are prevalent across cancer types & correlate w/ clinical outcomes but remain difficult to study. 1/n biorxiv.org/content/10.110…
- First major Lowe lab event in 18 months. It was great to see everyone together and having fun. We are back!
