And so, my friends, it’s a wrap! Leaving Alnylam as CEO for the last time. The last 19+ years have been epic. Thanks to all my colleagues and supporters!
John Maraganore 🇺🇸🇬🇷🇺🇦
4,344 posts
Founding CEO of @Alnylam. Pioneered RNAi therapeutics as a whole new class of medicines for patients. Now bioentrepreneur-at-large. Opinions are my own.
- In Jan 2021, we launched our “Alnylam P5x25” strategy for building a top 5 biotech by end of 2025… On Friday, we achieved that milestone! AMGN > VRTX > REGN > GILD > ALNY Congrats to the amazing @Alnylam team!
- OMG, how does this happen!? DNA makes RNA makes specific protein structures based on codon usage nature.com/articles/s4146…
- Student interested in biotech via non-PhD/MD route reached out to me last year… he just got into Stanford undergrad. Here was my advice to him. 🧵1
- Read my Reflections on @Alnylam (and the importance of being unreasonable), published with @SpringerNature in @NatureBiotech. Many lessons over last 20 yrs.
- Happy B-Day @Alnylam!!! 18 years, 2 approved medicines, 2 more in registration, 11 more in Clin development, a WHOLE NEW CLASS OF MEDICINES!!! And, we’re still a teen!
- Very excited to launch City Therapeutics this am!!!! “I’m a big believer in where Alnylam is going, but RNAi is even bigger than that, and there’s a need for new pioneers in the space. City Therapeutics is my next-generation RNAi play.”
- With today’s @US_FDA approval of ONPATTRO, the 1st FDA-approved #RNAi tx, we mark the arrival of an exciting new class of medicines that has been >15 years in the making! More important is the new hope this will bring to a #raredisease community so greatly in need of treatments.
- Thrilled to be joining ARCH as a Venture Partner as part of my plan to work with leading VCs! Looking forward to working w/ the team & the next generation of biotechs to advance promising science that can improve patients' lives.
- After a week where we announced our CEO transition, going home for the weekend feeling SO proud of what we’ve accomplished (so far) with #RNAi Rx for patients! More coming!!!
- Proud day! Validation of 15 years of scientific endeavor! 1st ever positive Ph3 results for #RNAi therapeutic. bit.ly/2hhuUm5
- Same story, 14 years and one day later. For the sake of patients, let’s hope for the same outcome! Keep going, CRISPR folk!
- My father died a little over a year ago with Alzheimer’s, a disease that robbed him off his life’s memories. This is a very sad day!!! To my friends at @biogen, thanks for trying and don’t give up! endpts.com/biogens-alzhei…










