Thrilled to share (a few days late) our work describing how to more consistently activate human genes from enhancer and other distal sequences using CRISPR activators (published in Nature Methods nature.com/articles/s4159… free link: rdcu.be/csoDt ). In it, we tackle..1/9
J. Keith Joung
421 posts
Lead Translator @arenabioworks, formerly Professor of Pathology (on leave, 2023-2025) @HarvardMed, #geneediting, #CRISPR; views expressed are my own
- Super excited to unveil the revamped website of @JoungLab! Designed and built by the amazingly talented Joy Horng who combined my love of science & comics, created all the graphics, and even built her own comic book-style font!! Check it out here:
- Incredibly honored to accept the Samsung Ho-Am Prize in Medicine earlier this week in Seoul. I am very grateful to all previous and current members of the @JoungLab and our collaborators for all of their work & contributions to the gene editing work recognized by this award. 1/3
- Latest @JoungLab paper reporting new CRISPR cytosine-to-guanine base editors (CGBEs) is out in @NatBiotech nature.com/articles/s4158…. Great work by Ibrahim Kurt, @RonghaoZhou, @becausebiology, @sarapintogarcia, Bret Miller, @lm_langner & @JulesGrunewald. Link to summary below (1/2)
- Thank you, @ASGCTherapy. I am incredibly honored to receive this award, which recognizes the work of so many talented @JoungLab members and other collaborators I've had the privilege to work with over the past nearly 20 years..@JKeithJoung receives the Outstanding Achievement Award for his work in #geneediting! Congrats, Dr. Joung! #ASGCT23
- Excited to be part of the inaugural team at Arena BioWorks @arenabioworks and to work with the amazing scientists assembled there to advance human therapeutics with this new model for scientific innovation and discoveryWe're proud to unveil Arena BioWorks, a biomedical research institute with a mission to uncover mechanisms of disease by engaging in basic biological research that will be translated into lifesaving #biotech therapeutics. Learn more: prnewswire.com/news-releases/…
GIF - Excited to share that our collaboration with the labs of Joanna Yeh and @MarcelaMaus of @MGH_RI was published online today in @NatureBiotech describing the use of CRISPR prime editors as ribonucleoprotein (RNP) complexes in zebrafish and human cells (1/2)CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells go.nature.com/336sL4V
- Congratulations to co-first-authors @JulesGrunewald @RonghaoZhou, co-second-authors @CalebLareau @sarapintogarcia @becauseBiology, and Bret Miller, @lm_langner @jyhsu15 @martinaryee on their paper describing dual-deaminase CRISPR base editors published today in @NatureBiotech 1/3A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing go.nature.com/2XmMUSn
- Our department held a pumpkin carving contest yesterday and some members of the @JoungLab won with this pumpkin! I have to admit that my face on a pumpkin is not something I ever imagined I would see...! 😂(Thanks to @ReganSzalay for the pictures.)
- Excited that the latest @JoungLab paper describing split #CRISPR prime editors is out online @NatureBiotech today. This work was led by @grunewaju, Bret Miller, @ReganSzalay with co-authors Peter Cabeceiras, Chris Woodilla @elizajaneholtz @Karl_Petri nature.com/articles/s4158… 1/7
- It was one of the most inspiring & heartwarming moments of my professional career to have 21 years of @JoungLab members & alums gather together the other evening to celebrate their accomplishments and the (belated) 20th anniversary of our group. More pictures in tweets below. 1/5
- Thrilled that @chromamedicine is emerging from stealth today and excited to be part of this great team working to develop epigenetic editing-based medicines. My own interest in epigenetic editors goes back many years...1/nWe are excited to introduce Chroma Medicine, a genomic medicine company pioneering epigenetic editing to precisely regulate gene expression in disease. Learn more: bit.ly/3cl64yF
- Finally posting something I wrote last fall but waited until now to send: "Feeling a mixture of gratitude and sadness as I left my office @MGHRI for the last time this afternoon (Sept 17). Since starting as a non-tenure track junior faculty member @MGHPathology on..(1/3)



















