This study found that women with breast cancer who used vaginal estrogen therapy (vaginal creams or vaginal tablets), compared with no hormone replacement therapy use, did not appear to have an increased risk of early breast cancer-specific mortality. ja.ma/3QpcVL2
JAMA Oncology
18.7K posts
JAMA Oncology is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.
- Most cancer drugs granted accelerated approval did not demonstrate benefit in overall survival or quality of life within 5 years of accelerated approval. ja.ma/3J3zZMi #AACR24
- Viewpoint: The rise in early-onset cancers in individuals under 50 may be explained by accelerated biological aging, with aging and cancer sharing common mechanisms. ja.ma/4myVLcs
- This study found that autologous tumor lystate-loaded dendritic cell vaccination plus standard of care (SOC) was associated with improved survival in both newly diagnosed & recurrent glioblastoma compared with matched controls who received SOC treatment. ja.ma/3knl0Ud
- This study found that autologous tumor lystate-loaded dendritic cell vaccination plus standard of care (SOC) was associated with improved survival in both newly diagnosed & recurrent glioblastoma compared with matched controls who received SOC treatment. ja.ma/3Ekm2Xm
- Patients who pursued #ComplementaryMedicine for breast, prostate, colon or lung cancer had a significantly worse overall survival, likely explained by delays in or refusal to pursue conventional #cancer therapies ja.ma/2LbVSh2 @sky__john @cpgYALE @YaleCOPPER @jamesbyu
- Viewpoint discusses how "skimming the median" can exaggerate survival gains in clinical trials, underscoring the need to critically evaluate Kaplan-Meier curves alongside hazard ratios. ja.ma/4jePW1F
- You send plasma from same patient for cell-free DNA testing to two different companies. In nearly all cases, you get different results from each. Data offer humbling reminder of imprecision of #PrecisionMedicine. ja.ma/2BfT8G4
- Phase 3 oncology RCTs often report positive results based on alternative end points, but actual improvements in overall survival or quality of life are rare, highlighting need to prioritize these outcomes in future research & regulatory processes. #ASCO25 ja.ma/3FCoVHI
- Viewpoint: The growing use of immune checkpoint inhibitors in cancer treatment brings significant therapeutic benefits but also long-term immune-related adverse effects. ja.ma/4gYT8NR
- Viewpoint: The rise in early-onset cancers in individuals under 50 may be explained by accelerated biological aging, with aging and cancer sharing common mechanisms. ja.ma/3Hdx1Hb
- After accounting for biases and confounders, cancer clinical trial participation was not associated with longer survival. ja.ma/44NAqEq
- Most viewed this week from @JAMAOnc: Prophylactic IV magnesium administration was associated with a lower risk of cisplatin-associated acute kidney injury (CP-AKI) in patients with cancer undergoing cisplatin chemotherapy. ja.ma/44fFHqa
- Viewpoint: Prostate cancer screening is shifting toward a more beneficial and less harmful approach by using MRI-targeted strategies, which reduce unnecessary biopsies and overdiagnosis. ja.ma/45rVOSb @IvoSchootsNL











