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Itai Yanai
@ItaiYanai
Professor at the NYU School of Medicine. Co-host of the 'Night Science Podcast' @nightsciencepod and Co-founder of the Night Science Institute night-science.org
NYU, School of Medicine
Joined January 2015
Posts
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    Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️ nature.com/articles/s4158… @Gustavo_SFranca
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    Doing good science is 90% finding a science buddy to constantly talk to about the project.
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    New Nature paper provides evidence that science has become less innovative since the 1950s. The authors suggest reversing the trend by: 1. reading widely, 2. focusing less on quantity of papers, & more on research quality, 3. taking year-long sabbaticals. nature.com/articles/s4158…
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    I must admit that this annotated Nature abstract remains a useful recipe for constructing a summary paragraph. I show it to my students every time we get started.
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    I met a scientist who was just trying to do good science. No Nobel prize fetish. No imposter syndrome. No deep desire for flashy publications. No venting about evil reviewers. No need to gossip about other scientists. Only doing good science. Like a psychopath.
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    If you don’t feel stupid doing science you’re not trying hard enough.
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    Science is not really happening when the goal is a paper, a presentation, a grant, or any product. It only really happens when the goal is a process of discovery.
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    Doing a PhD is - at heart - one long discussion with your mentor. The discussion changes over time - with unexpected turns and ups & downs - but through it all is a pair of people discussing a topic endlessly to make sense of it. PhD students: choose someone you like to talk to!
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    PhD students tend to choose a lab based on the topic, but a creative and supportive environment is more important. If everyone in the lab is miserable, you will probably be miserable there too; and if they are happy and thriving, you'll also likely feel good about yourself there.
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    90% of doing science is being open to new ideas.
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    Is the scientific paper a fraud? Peter Medawar (Nobel Prize winner) suggested that publications are overly structured and formal, giving only a sanitized version of the discovery without revealing the thought process that actually led to it.
    https://www.weizmann.ac.il/mcb/alon/sites/mcb.UriAlon/files/uploads/medawar.pdf
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    If you think the next big idea in your field will come from inside the field, you're probably wrong.
    https://genomebiology.biomedcentral.com/articles/10.1186/s13059-020-01985-6
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    Out today in @NatureBiotech! PhD students & postdocs: there's a trick – overlooked and underused – for having new ideas in the creative process. Talk science 1 on 1 with a science buddy that you trust and think of it as an improvisation. nature.com/articles/s4158…@MartinJLercher
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    It’s crazy how talking with a science buddy is simultaneously what’s most likely to move the project forward and the thing that’s least prioritized in our schedule.