user avatar
Olivier Elemento
@ElementoLab
Director, Englander Institute for Precision Medicine @WCMenglanderIPM, Associate Director @wcmc_ctsc & ICB, Co-Founder @volastratx & @onethreebiotech
New York city
eipm.weill.cornell.edu
Joined January 2012
948
Following
6,223
Followers
Posts
  • user avatar
    Olivier Elemento
    @ElementoLab
    Nov 27, 2021
    Wow - cancer patients who took certain anti-histamine medications because of allergies responded better to immunotherapy. Turns out histamine binds to macrophage receptors, makes macrophages immunosuppressive, thus inducing T cell dysfunction cell.com/cancer-cell/fu…
  • user avatar
    Olivier Elemento
    @ElementoLab
    May 16, 2022
    This mind-blowing research in @Nature shows that machine learning can effectively guide enzyme optimization and help create enzymes that degrade all kinds of plastic waste in record time 🤯nature.com/articles/s4158…
  • user avatar
    Olivier Elemento
    @ElementoLab
    Aug 19, 2022
    This 2018 study found that 80% of the “most transformative” medicines approved for clinical use by the FDA could be traced back to one or several basic discoveries, which occurred on average three decades before approval! science.org/doi/10.1126/sc…
  • user avatar
    Olivier Elemento
    @ElementoLab
    Nov 28, 2021
    Very impressive evidence that a 5-day fasting-mimicking diet (low-carb, low-protein) visibly enhances antitumor immunity in the periphery & tumor itself, and decreases pro-tumorigenic signals in cancer patients! cancerdiscovery.aacrjournals.org/content/early/…
  • user avatar
    Olivier Elemento
    @ElementoLab
    Sep 19, 2021
    What are some of the emerging and most promising AI applications in cancer? The biggest challenges for implementation of AI in clinical practice? What's the future of AI in oncology ? Three great colleagues and and I tried to provide answers nature.com/articles/s4156…
  • user avatar
    Olivier Elemento
    @ElementoLab
    Nov 7, 2021
    Prostate cancer frequently metastasizes to bone and nobody knows why. New study of prostate cancer bone metastases at single-cell resolution identifies changes in the bone microenvironment that may help tumor cells evade immune surveillance there cell.com/cancer-cell/fu…
  • user avatar
    Olivier Elemento
    @ElementoLab
    Sep 6, 2021
    Kinase inhibitors are among the most successful drug classes ever - yet they have so much more to give, with 70% of the kinome still unexplored in drug development. This review provides a comprehensive overview of what continues to be a very exciting field nature.com/articles/s4157…
  • user avatar
    Olivier Elemento
    @ElementoLab
    Dec 29, 2021
    Impressive single-cell transcriptomic analysis of 390,000 T cells from 316 patients and 21 cancer types reveals new T cell subpopulations, cell state transition dynamics, new transcriptional regulators & much more! Well done Zeming Zhang & team @PKU1898 science.org/doi/10.1126/sc…
  • user avatar
    Olivier Elemento
    @ElementoLab
    Jul 8, 2024
    Wow! GLP-1 receptor agonists now linked to a substantial reduction in incidence for 10 types of cancers, in patients with Type 2 Diabetes !jamanetwork.com/journals/jaman…
    180K
  • user avatar
    Olivier Elemento
    @ElementoLab
    May 14, 2022
    Thank you @US_FDA for issuing draft guidelines for use of ctDNA in drug development for solid tumors in the early stage, non-metastatic setting. Will likely become standard for rapid patient selection and treatment response assessment fda.gov/regulatory-inf…
  • user avatar
    Olivier Elemento
    @ElementoLab
    Oct 17, 2021
    Why do so many cancers metastasize to the bone? does the bone serve as a ‘launch pad’ for secondary metastasis? what are the emerging therapeutic targets for combatting bone mets? brilliant review by @lab_bcm nature.com/articles/s4156…
  • user avatar
    Olivier Elemento
    @ElementoLab
    Apr 4, 2021
    Our paper on using Deep Learning to predict Chromosomal Instability from Histopathology Images is out. Comments/feedback/ideas welcome ! cell.com/iscience/fullt…
  • user avatar
    Olivier Elemento
    @ElementoLab
    May 7, 2022
    The emerging role of mass spectrometry-based proteomics in drug discovery - fast-growing number of applications from discovery of novel targets to uncovering mechanisms of action of candidate compounds nature.com/articles/s4157…
  • user avatar
    Olivier Elemento
    @ElementoLab
    Jan 22, 2022
    Studying brain metastasis? new single-cell RNAseq paper in @CellCellPress describes a detailed catalog of the functional cell types and cellular states found in human brain metastases cell.com/cell/fulltext/…