We knew they were great! Congrats to Buck professors @EricVerdin, Judith Campisi, Martin Brand and @HetzLab for being recognized by @Clarivate as being among the world’s most highly cited researchers!
Buck Institute
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Buck Institute
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Our mission is to end the threat of age-related disease for this and future generations
- For the first time, Alpha-ketoglutarate has been shown to improve #healthspan in mice. Mice fed #AKG had 40% ↑ healthspan and some ↑ #lifespan, too. Congrats to Azar and the Lithgow lab on this major contribution to the field! #livebetterlonger
- Judy Campisi published nearly 500 papers and had almost 105,000 citations. We are honored to share one very influential paper which describes the SASP (#senescence associated secretory phenotype). A new concept then, it is enshrined in modern #geroscience.
- Could taurine be an anti-aging intervention in humans? Landmark study @ScienceMagazine shows restoring “youthful” levels of taurine hit several hallmarks of aging in worms, mice and monkeys. Buck researchers were involved in the work and talk about here:
- 📢 time! Dr. Malene Hansen is joining Buck as our new Chief Scientific Officer! Buck CEO Eric Verdin sums it up: “She is an extraordinary scientist with the background, vision, and skills to enhance our leadership position and to accelerate our mission"
- As we mourn loss of and celebrate life of Judy Campisi, enjoy listening to interview she did for our podcast. It’s great tutorial on #cellularsenescence and her comment on “failed experiments” is classic Judy. Details about memorial service are pending
- Both honored and sad to share obituary for Judy Campisi @Nature. Many thanks to Jan Vijg and Jan Hoeijmakers for recounting Judy’s pioneering work in cellular senescence and highlighting the personal attributes which made her beloved colleague and friend nature.com/articles/d4158…
- We now know what drives #wrinkles and other signs of skin aging. Study @NatureAging reveals high levels of pro-inflammatory cytokine IL-17 are expressed in skin immune cells with aging. Inhibiting it temporarily in mice delayed appearance of aging in skin.
- Our own Dr. Judy Campisi and former Buck scientist Dr. Chris Wiley take a deep dive into the metabolic roots of senescence @NatMetabolism. Their review also discuss mechanisms and opportunities for interventions. Great read!
- As we age, our cells are less likely to express longer genes. An editorial @TrendsGenetics posits that many aging phenotypes across multiple animals, including humans, could be occurring due to this phenomenon. Could this be main cause of systemic aging?
- Too good to be true? Study in @NatMetabolism finds that natural molecule found in coffee (trigonelline) boosts levels of #NAD+ and improves muscle function during #aging, providing target for #sarcopenia. Study was done in mice and worms.
- From bench to bedside in the biology of aging. Buck faculty @EricVerdin @GeriSciDoc #JudyCampisi #SimonMelov #GordonLithgow & #PankajKapahi publish Review in @nature chronicling 30 years of research on aging. #Livebetterlonger nature.com/articles/s4158…
- Cellular rejuvenation therapy using variations of the #Yamanaka factors safely reverses aging in healthy mice as they age - there was no increase in cancer or neurological problems. Study @NatureAging comes from @Salk and @genentech.
