In a recent @PharmExec feature by @PharmexecM, Oren Gilad of Aprea Therapeutics explains how synthetic lethality targets #cancer's genetic mutations, aiming for effective treatment with fewer side effects. bit.ly/475mo27 $APRE #CancerResearch #PrecisionMedicine
Aprea Therapeutics (NASDAQ: APRE)
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Aprea (NASDAQ: $APRE) is developing innovative precision therapies for cancers with specific genetic alterations to potentially minimize damage to healthy cells
- New preclinical data for Aprea's next-generation WEE1 Inhibitor, APR-1051, demonstrate robust single agent activity and significant synergy with anti-PD-1 immunotherapy in HPV+ head and neck squamous cell carcinoma (HNSCC). Read more: bit.ly/4lkj0Gr $APRE
00:00 - Aprea is on a mission to increase the specificity and reduce the toxicity of DNA Damage Response (DDR) inhibitors to give cancer patients more choices. Learn about our therapeutic pipeline here: bit.ly/3WSYDq6 $APRE
00:00 - Dr. Anthony Tolcher, Investigator in the ongoing ABOYA-119 Phase 1/2a clinical trial, comments on the first patient being dosed at Dose Level 7 of ATRN-119 550 mg twice daily: bit.ly/3VCdBQH $APRE
00:00 - "We are very encouraged by these early findings and see APR-1051 as a potentially promising addition to the therapeutic portfolio for treating HPV-associated head and neck cancers," said Drs. Abdullah Osman and Jeffrey Myers from The University of Texas @MDAndersonNews.
00:00 - Our world-class team of precision oncology experts is dedicated to advancing breakthrough therapeutics for patients with genetically defined cancers. Learn more about the Aprea leadership team here: bit.ly/40SsQqv $APRE
00:00 - “Our strong patent portfolio reflects our commitment to innovation and leadership in the field of DNA Damage Response (DDR) therapeutics," said Oren Gilad, Ph.D., Aprea CEO. Read more about Aprea's intellectual property portfolio: bit.ly/42GGvDC $APRE
00:00 - Replying to @ApreaTXThis is the first patient to be dosed in Cohort 5 of the ACESOT-1051 clinical trial. It is also the first patient to be enrolled in this important indication, following Aprea's Material Transfer Agreement with @MDAndersonNews. bit.ly/43yh9s1 $APRE #HNSCC
- Aprea Therapeutics discusses their progress of the two ongoing clinical studies and a third pre-clinical program, targeting specific #genetic mutations. Read more in this interview with @PHLBizJournal about how they’re advancing #precisionmedicine: bit.ly/3AYr5Pj $APRE
- Aprea Therapeutics today announced compelling new preclinical data and a preliminary clinical update for APR-1051, the Company’s next-generation oral WEE1 inhibitor, in human HPV+ HNSCC in collaboration with the world-renowned @MDAndersonNews. bit.ly/4lkj0Gr $APRE
00:00 - Eric Brown, Ph.D., Scientific Consultant for Aprea, presented at the 8th Annual DDR Inhibitors Summit in Boston last week, highlighting Aprea's development of DDR-targeting therapeutics to advance precision oncology. $APRE
- The goal of the research to be done under Aprea's agreement with @MDAndersonnews is to further characterize the potential of APR-1051 in HPV+ and HPV- #HNSCC and generate insights that could support future clinical development. Read more: bit.ly/3FkrXQw $APRE
00:00 - Oren Gilad, Ph.D., President and CEO of Aprea, emphasizes the significance of early-signs of clinical activity for APR-1051 in HPV+ #HNSCC, resulting from the ongoing research collaboration with renowned oncology leader @MDAndersonNews. Read more: bit.ly/4lkj0Gr $APRE
00:00 - "We are pleased with our progress in 2025, as emerging data from both of our lead programs demonstrate evidence of clinical activity,” said Oren Gilad, Ph.D., President and CEO. For key business updates and potential upcoming milestones: bit.ly/414Jx30 $APRE
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