Alex Colville (@AlexJColville) / X

Alex Colville

1,114 posts

Alex Colville

@AlexJColville

General Partner at @age1vc extending healthy lifespan. PhD alum of @Thomas_Rando @stanfordmed

Stanford, CA

Joined July 2018

Pinned
Alex Colville
@AlexJColville
Sep 19, 2023
Why don’t we target the inevitable cause of our decline, aging, before it happens? Excited to announce a moonshot fund to catalyze the longevity field to new heights. We won’t stop until we all have agency over how long we can live in good health.
00:00
Laura 🌲 ⛰️
@LauraDeming
Sep 19, 2023
Excited to launch a new fund today: wsj.com/articles/new-v… I wrote here about my takeaways from the past decade + predictions for the next: longevity.vc
165K
Alex Colville
@AlexJColville
Dec 1, 2024
Replying to @katclone
More pictures do not clarify the situation...
48K
Alex Colville
@AlexJColville
Feb 26, 2024
The promise of epigenetic reprogramming to reverse aging is the Holy Grail of the aging field. It's led to $3.3B in funding in the past 3 yrs, and despite that, it took until now to see lifespan extension in normal aging mice. Some asked me if it’s legit, so I did a deep dive:
Cellular Reprogramming
@CellRepJrnl
Feb 22, 2024
Our new article reveals that gene therapy-mediated partial reprogramming extends lifespan and reverses age-related changes in aged mice, showcasing lifespan extension in wild-type animals through in vivo reprogramming. @eskamoah @cc_biology_ @rejuvenatebio liebertpub.com/doi/10.1089/ce…
238K
Alex Colville
@AlexJColville
Nov 24, 2024
🚨Breaking: Dr. Makary’s selection as head of FDA could reshape the aging field dramatically. He believes in the science and even thinks aging could be reversible. Could signal a shift in regulation that could leap the field forward. Watch below to see why folks are excited.
00:00
126K
Alex Colville
@AlexJColville
Feb 20, 2024
Wonder what that secretive longevity company funded w/ $3B from @JeffBezos and @yurimilner has been working on? SCOOP: @altos_labs latest public program is an oligonucleotide inhibiting the retrotransposon LINE-1 to treat progeria.
174K
Alex Colville
@AlexJColville
Sep 30, 2022
If you feel like you’re too young and inexperienced to make a difference in biotech, you need to study @JoshuaBCohen1 & @justin_klee. Yesterday they achieved a historic FDA approval for their drug for ALS…which they came up with in UNDERGRAD @BrownUniversity!! Here’s how:
Alex Colville
@AlexJColville
Jul 26, 2024
Remember the supermodel granny drug that extended lifespan by 25% in mice by IL-11 last week? It only took 8 days for a new intervention to come out increasing lifespan by 35%!! Some thoughts:
Alex Kesin
@alexkesin
Jul 26, 2024
BREAKING: Rapamycin + trametinib in combination extend maximum lifespan by up to 35% in mice
75K
Alex Colville
@AlexJColville
Mar 25, 2024
One of the biggest cultural shifts in life science PhD programs over the past decade - industry directly replacing academic jobs for graduates Source: @NSF @DrChrisTSmith
172K
Alex Colville
@AlexJColville
Sep 3, 2024
Big news: @bioagelabs has filed for IPO!!! Massive moment for the aging field as they will be one of only a handful of companies to make it to the public markets (Unity Biotech, resTORbio, etc). 9 years in the making for BioAge, huge congrats to the team.
26K
Alex Colville
@AlexJColville
Oct 25, 2023
how it started: how it's going:
30K
Alex Colville
@AlexJColville
Dec 11, 2023
For biotech companies started in the last 50 years that were acquired for at least $10B or that trade at market caps of at least $10B, 6 out of the 21 CEOs were between 29 and 35 years old.
Julian Shapiro
@Julian
Dec 11, 2023
Younger people need to stop waiting around thinking that older folks—especially politicians—are going to fix the world. The average age of the moon landing control room was 28. The average age of the Manhattan Project scientist was 25. US Founding Fathers were only...
37K
Alex Colville
@AlexJColville
Aug 27, 2024
Nothing will inspire you as a founder like Europe.
11K
Alex Colville
@AlexJColville
Dec 12, 2023
Shockingly few have baked into their mental calculus what this means for the future of biotech.
age1
@age1vc
Dec 11, 2023
We found that a drug approved and indicated for aging would conservatively have a peak global market size ~$150-$200 billion annually. A company that owned only this drug would be more valuable than the top 2 big pharma companies (J&J and Pfizer) in terms of revenue…combined.
34K
Alex Colville
@AlexJColville
Nov 28, 2023
ATTENTION: the biggest longevity biotech milestone achieved to date.
Celine Halioua
@celinehalioua
Nov 28, 2023
1 - Loyal has earned what we believe is the FDA’s first-ever formal acceptance that a drug can be developed + approved for lifespan extension 2 - We have 'technical section complete' AKA the 'does it work' data for LOY-001 - our large dog lifespan extension drug - is done
15K