Alberto J Espay (@AlbertoEspay) / X

Alberto J Espay

4,295 posts

Alberto J Espay

@AlbertoEspay

#Neurology professor @uofcincy, advocate of precision medicine in neurodegeneration, author #BrainFables. More active on LinkedIn.

Cincinnati, OH

Joined October 2019

Pinned
Alberto J Espay
@AlbertoEspay
Jun 27, 2025
How does physics inform neurodegeneration? Supersaturation lowers the nucleation barrier for the precipitation of monomeric proteins into their pathological state. In normal aging, replacement matches loss; in accelerated aging, it does not. (1/4)
Physics of Protein Aggregation in Normal and Accelerated Brain Aging
From onlinelibrary.wiley.com
7.6K
Alberto J Espay
@AlbertoEspay
Sep 26, 2024
One of the world’s leading scientists in Parkinson’s and Alzheimer’s research may have fabricated images in 132 papers published from 1997 to 2023. This isn’t just a waste of funds but a betrayal of scientific integrity and a threat to our patients. (1/2)
Did a top NIH official manipulate Alzheimer’s and Parkinson’s studies for decades?
From science.org
89K
Alberto J Espay
@AlbertoEspay
Jun 11, 2024
Open letter to my dear Alzheimer's patients. @alzassociation
77K
Alberto J Espay
@AlbertoEspay
Sep 24, 2022
Are neurologists losing their clinical skills? This was the question posed by Andrew Lees (⁦@ajlees⁩) at the #Neuro2022 Congress in Fortaleza. The risks of relinquishing the value of history and examination to surveys and tests are real. Solutions are within reach.
Alberto J Espay
@AlbertoEspay
Jul 7, 2023
Lecanemab (Leqembi) --A Visual Abstract of the data for the Consumer. #Alzheimers #Leqembi @alzassociation @alzforum
56K
Alberto J Espay
@AlbertoEspay
Aug 4, 2022
I learned in medical school that clinical trials are the best test of a hypothesis. In this week’s issue of @NEJM, two anti-synuclein trials tested the hypothesis that α-synuclein is toxic and both were negative. What keeps us from falsifying the hypothesis? (1/8)
Alberto J Espay
@AlbertoEspay
Nov 2, 2024
This is progress. Expert IWG #Alzheimers clinicians recommend against the disease-without-symptoms 'biologically defined' @alzassociation criteria and clarify that treating pathology doesn't necessarily mean treating disease. @nvillain_alz @LonSchneiderMD jamanetwork.com/journals/jaman…
15K
Alberto J Espay
@AlbertoEspay
May 4, 2020
Concise Neurology 2nd Edition is out! This labor of love, rewritten 10 years later with one of my most treasured mentors, Dr. José Biller, remains committed to making neurology the most exciting field of medicine. #Neurology @AANmember @LoyolaMedMD @uofcincy
Alberto J Espay
@AlbertoEspay
Jul 17, 2023
Donanemab in early symptomatic Alzheimer's disease - Infographic of the phase 3 trial data published by JAMA earlier today. Highlights: • No improvement • ~3-point less worsening in iADRS (below MCID) • 3.4% slower decline (not 35%!) @alzforum @alzassociation
41K
Alberto J Espay
@AlbertoEspay
Sep 12, 2024
An analysis of 24 randomized trials involving 25,000 Alzheimer's patients suggests an alternative explanation for how anti-Aβ monoclonal antibodies work: they may slow cognitive decline by raising Aβ42 levels. 🧵(1/12)
Increases in amyloid-β42 slow cognitive and clinical decline in Alzheimer’s disease trials
From academic.oup.com
51K
Alberto J Espay
@AlbertoEspay
Apr 22, 2023
With immense pride, I am honored to announce that one of the brightest @UCincyMedicine former fellows, Dr. Abhi Mahajan (@AMahajanMD), will return to Cincinnati to join our faculty as of September. We celebrated in Boston on the eve of #AANAM 2023. Welcome back, Abhi! 🥳🎉
12K
Alberto J Espay
@AlbertoEspay
Jun 28, 2024
You are normal but tested positive for amyloid. Will you get dementia? Here is your Essential Consumer Guide.
28K
Alberto J Espay
@AlbertoEspay
Nov 6, 2022
Population screening for bradykinesia.
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Alberto J Espay
@AlbertoEspay
Apr 13, 2024
#Alzheimers can’t be defined by Amyloid, the 9-to-1 winning argument by ⁦@MayoClinic⁩ David Jones, who argued that a disease does not exist without symptoms and brain dysfunction. The brave new “biological definition” world of AD will not prevail. #AANAM 2024
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