This downloadable scientific poster highlights breakthrough data showing that conventional planar MEAs can distort organoid morphology and lose activity over time, while the Mesh MEA’s integrated scaffold preserves structure, synapses, and functional network activity across weeks of culture.
Using transcriptomic analysis and functional assays, the researchers identified disrupted transcriptional networks regulated by CHD1L that affect brain development and cellular growth. Their findings provide mechanistic insights into how CHD1L influences neurodevelopmental processes.
Whether you’re running a busy research lab, fine-tuning a microfluidics setup, or preparing a precise dose-delivery experiment, the syringe pump at the centre of your workflow can make or break your results. But with so many models, specs, and marketing claims out there, how do you separate the truly high-quality pumps from the rest?
Organoids are becoming powerful, functional systems that survive shipping, form vascular networks, and reveal early disease risk. Read three publications from the past year that demonstrate how researchers are pushing organoid research to the absolute limit using multielectrode array technologies from Multi Channel Systems.
This Heart Month, explore why continuous physiology is essential for cardiovascular research. From subtle, time-dependent signals to integrated cardiometabolic insights, longitudinal physiological monitoring provides a more complete understanding of cardiovascular function—at rest, under challenge, and over time. Learn how capturing physiology as it unfolds can support more predictive, translational research outcomes.
The IntraCell system can be used to take measurements from organoids as well, using both 9-well multiwell MEAs as well as Multi Channel Systems' novel Mesh MEA, which allows for the recording of true-to-life data from inside an organoid without changing its morphology for the first time.
By measuring Gem absorbance at 269 nm, the Biowave enabled precise determination of unencapsulated drug and calculation of EE%. Such reproducible spectrophotometric data was critical in validating formulation design, ensuring nanoparticle stability, and correlating entrapment with downstream release kinetics.
For this study, mature cerebral organoids (6-7 months old) were transferred to a Mesh MEA using a polyethyleneimine and laminin coating protocol and BrainPhys cell culture media. After 3 weeks in culture, COs displayed higher electrical activity on the Mesh MEA compared to planar MEA chips, which contained either flat or 3D-spike electrodes.
In the Abilez et al. study, the HEKA EPC 10 Patch Clamp Amplifier provided the sensitivity, stability, and control needed to investigate individual cells within the complex 3D environment of the organoid.
These findings demonstrate how electroporation can enhance the effectiveness of immunotherapies, offering a promising path for more potent and durable cancer treatments.
