Using a Child Theme, you can copy the framework/layouts/content-grid_2_column.php file into your child theme folder (maintaining the folder structure too), which you can then safely modify to suit your needs.
I’ve added target="_blank" to both hyperlinks, as shown below.
<?php if (has_post_thumbnail()) : ?>
<a href="<?php the_permalink() ?>" title="<?php the_title_attribute() ?>" target="_blank"><?php the_post_thumbnail('synapse-pop-thumb'); ?></a>
<?php else: ?>
<a href="<?php the_permalink() ?>" title="<?php the_title_attribute() ?>" target="_blank"><img src="<?php echo get_template_directory_uri()."/assets/images/placeholder2.jpg"; ?>"></a>
<?php endif; ?>
Hope this helps.