... unmet medical needs in cancer, announced that its novel next-generation BTK-targeted protein degrader, APG-3288, has received the IND clearance from the U.S.
... rather than inhibition, inducing rapid, potent, highly selective, and sustained degradation of both wild-type BTK and multiple BTK mutants associated with resistance to existing BTK inhibitors.
Sanofi's Wayrilz approved in the EU as the first BTK inhibitor to treat immune thrombocytopenia •. Novel treatment targets BTK through multi-immune modulation to help address the underlying causes of ITP.
PITTSBURGH , Dec. 22, 2025 /PRNewswire/ -- "I wanted to create a high-end and attractively-styled portable restroom that is larger and much more home-like," said an inventor, from Trussville, Ala., "so I invented 21ST CENTURY JOHNS ... 21% ... .
PITTSBURGH , Dec. 22, 2025 /PRNewswire/ -- "I wanted to create an improved charger that enables you to charge your electronic devices at any place or time," said an inventor, from Fairfield, Ala., "so I invented the SUNCHARGE... 21% ... .
Overall, BTK inhibitors and ICH-related therapies sit in a space with strong scientific momentum but notable hurdles ... Overall, BTK inhibitors and ICH-related therapies sit in a space with strong scientific momentum but notable hurdles.
About Jaypirca (pirtobrutinib) Jaypirca (pirtobrutinib, formerly known as LOXO-305) (pronounced jay-pihr-kaa) is a highly selective (300 times more selective for BTK versus 98% of other kinases ...
PITTSBURGH, Dec. 1, 2025 /PRNewswire/ -- "As a cashier, I stand on my feet for long periods of time ... The invention provides a new line of footwear designed to increase comfort when standing for long periods of time ... It also could help relax the user ... .
PITTSBURGH, Dec. 1, 2025 /PRNewswire/ -- "I thought there could be an improved means of sealing a leak in an underwater oil well," said an inventor, from Pensacola, Fla., "so I invented the JULIUS CEASAR ... SOURCE InventHelp. 21% ... .
PITTSBURGH , Dec. 1, 2025 /PRNewswire/ -- "I wanted to create a cleaning tool that would allow you to clean ceiling fan globes and blades in a safe and efficient manner," said an inventor, from Northport, Ala., "so I invented THE ... 21% ... .
PITTSBURGH, Nov ... My design could allow women to use the restroom in a quick, easy, and convenient manner." ... As a result, it increases comfort ... 24-BTK-356, InventHelp, 100 Beecham Drive, Suite 110, Pittsburgh, PA 15205-9801, or call (412) 288-1300 ext ... .
PITTSBURGH, Nov ... My design enables a fisherman to engage in other activities nearby without constantly monitoring the fishing rod." ... 24-BTK-357, InventHelp, 100 Beecham Drive, Suite 110, Pittsburgh, PA 15205-9801, or call (412) 288-1300 ext. 1368 ... 21% ... .
PITTSBURGH, Nov ... My design increases sanitation, safety, and convenience when plunging the toilet." ... For more information, write Dept. 24-BTK-347, InventHelp, 100 Beecham Drive, Suite 110, Pittsburgh, PA 15205-9801, or call (412) 288-1300 ext. 1368 ... 21% ... .