KREX Technology:
Redefining Antibody Profiling
Unlock actionable insights, from biomarkers to therapies
The ultimate platform for high-plex antibody profiling
KREX™ technology is the only high-plex antibody profiling solution designed to deliver reproducible insights into the immunoproteome with unmatched precision. Its unique combination of advanced features enable:
- Correctly folded proteins: preserves critical protein structures, recognized by 90% of antibodies, to ensure biologically relevant interactions
- Mean CV <10%: ensures consistent results across replicate protein spots, enabling confident data interpretation and analysis
- FDR <1%: reduces false positives, enhancing data precision for meaningful and trustworthy discoveries
- High sensitivity and wide dynamic range: picomolar (pM) sensitivity with a linear range across 5 logs
- Dual isotype analysis: simultaneous insights into two antibody isotypes (IgG, IgA, IgM)
Comprehensive services
discovery
biology
screening
development
modifications
discovery
Identify and validate biomarker signatures with confidence
KREX technology enables high-multiplex profiling of antibodies against thousands of proteins, uncovering actionable biomarkers for early diagnosis, molecular subtyping, risk management and beyond – driving progress in precision medicine.
biology
Understand disease mechanisms with precision antibody profiling
KREX technology reveals the antibody-based immune response to molecular disease processes, enabling identification of protein antigens, protective antibodies and pathogenic antibodies linked to disease onset, progression and severity. These insights uncover disease-driving pathways, improve understanding of host-pathogen interactions, and accelerate the development of new diagnostics and therapies.
screening
Screen immunotherapy drug targets rapidly and efficiently
Characterizing the specificity and off-target binding of antibody-based drugs is critical for ensuring safety and efficacy. KREX technology enables high-throughput screening, empowering you to evaluate drug interactions across thousands of correctly folded proteins. By identifying optimal targets and minimizing off-target effects, KREX technology accelerates the development of safer, more effective immunotherapies.
development
Streamline vaccine development with advanced antibody profiling
KREX technology delivers actionable insights across every stage of vaccine development – from identifying antigens to optimizing dosing and delivery. By profiling antibodies against thousands of correctly folded proteins, KREX accelerates timelines, reduces costs and supports the design of safer, more effective vaccines.
modifications
Study the immune response to citrullinated proteins
Explore the immune response to inflammation and cellular damage with our exclusive Citrullination Assay. Compatible with select KREX microarrays, this assay enables highly multiplexed and sensitive detection of autoantibodies targeting citrullinated proteins – key players in diseases such as rheumatoid arthritis, neurodegenerative disorders and cancer. By integrating the Citrullination Assay into KREX technology, you can uncover disease-specific biomarkers, gain deeper insights into immune response mechanisms and drive therapeutic development.
Expert data analysis support for antibody biomarker research
Our bioinformatics experts provide tailored, comprehensive support – from study design to multivariate modeling – to transform your results into meaningful discoveries. Using advanced algorithms and machine learning, we enable de novo patient stratification, integrate experimental and clinical data, and conduct detailed biological pathway analysis. This flexible and customized approach empowers you to uncover novel insights into disease mechanisms, immune responses and therapeutic targets.
Flexible options
For Research Use Only. Not for use in diagnostic procedures.