Overview
Reviewed by Pouyan Golshani, MD — Interventional Radiologist
Key Features
- FDA-Cleared Agentic AI
- EHR and Workflow Integrated
- Connect with patients between visits
- Gather structured health information
- Coordinate with care teams
- Deliver physician-level interventions
- Continuous, evidence-based clinical intervention
- Physician governed accountability
- Enterprise Grade
Use Cases
- Chronic disease management between visits
- Delivering personalized patient guidance
- Coordinating care team efforts
- Implementing physician-prescribed treatment plans
- Improving patient adherence and outcomes
- Reducing avoidable hospitalizations
What Physicians Need to Know
Evidence Base
UpDoc's Clinical Intelligence platform unifies clinical guidelines, longitudinal patient context, physician governance, and EHR data. It aims to democratize the latest evidence-based medicine. The platform's approach to chronic disease management, specifically insulin titration for Type 2 diabetes, was validated in a Stanford clinical trial published in JAMA Network Open.
Clinical Validation Studies
UpDoc's clinical AI platform is FDA-cleared as a Software as a Medical Device (SaMD) for medication management in adults with Type 2 diabetes, specifically for insulin treatment plan instructions. This clearance follows a landmark clinical trial led by its founders at Stanford Medicine (MIVA trial, NCT05081011), with results posted in January 2024 and a related paper in JAMA Network Open in December 2023, which studied voice-based conversational AI for basal insulin prescription management.
Override Rate Data
Specific override rate data for UpDoc is not publicly available. However, in general, high override rates in clinical decision support systems can indicate a need for refining AI models or alert design. UpDoc's model emphasizes physician governance, where the physician prescribes and the AI implements within those parameters, suggesting a controlled environment for AI actions.
Drug Interaction Checking
UpDoc's primary FDA clearance is for insulin management in Type 2 diabetes. While AI tools generally show promise in identifying drug-drug interactions (DDIs) more efficiently and accurately than traditional methods, with some studies demonstrating significant reductions in processing time and improved detection of interactions, specific details on UpDoc's drug interaction checking capabilities beyond its core insulin management function are not highlighted.
Differential Diagnosis Support
UpDoc's current focus is on chronic disease management and medication prescriptions, particularly insulin titration for Type 2 diabetes. There is no specific information indicating that UpDoc provides differential diagnosis support. Other AI tools in the market are noted for generating ranked differentials from natural-language inputs and linking diagnoses to evidence.
Clinical Workflow Integration
UpDoc was purpose-built as a clinical operating system embedded directly into provider workflows and is integrated with electronic health records (EHRs). It aims to reduce administrative burden and enable physicians to focus on high-value clinical decision-making by automating interventions like medication adjustments, lab orders, and care team coordination.
Decision Audit Trail
UpDoc's platform is designed with 'Accountability by Design,' ensuring every clinical action falls within the patient's treatment plan and accountability is traceable. The system documents the entire intervention in the EHR. General principles for healthcare AI audit trails emphasize capturing user actions, system events, AI model details, and the reasoning behind decisions for compliance, transparency, and patient safety.
Physician Tip
UpDoc is an FDA-cleared agentic AI platform designed to support, not replace, physicians in managing chronic diseases, particularly Type 2 diabetes. It automates interventions like insulin titration and lab orders within physician-approved parameters, extending care between visits. Physicians maintain governance over the AI's actions, prescribing the treatment plan that the AI then implements. This can free up physician time for high-value decision-making and potentially improve patient outcomes for chronic conditions.
UpDoc is designed for seamless integration into existing clinical workflows and Electronic Health Record (EHR) environments. It is undergoing initial deployments at premier healthcare systems including Cleveland Clinic, Allegheny Health Network (AHN), and UCSF Health. The platform leverages multiple large language models, including GPT-4 through Azure OpenAI, Google Cloud MedLM, and Vertex AI models.
Details
| Category | Clinical Decision Support & Reference, Patient Engagement & Education, Telehealth & Virtual Care |
| Pricing |
Unknown
|
| Deployment | Cloud-based application, integrated with EHR systems. |
| Mobile App | Yes, a patient mobile app is part of the platform. |
| Languages | English, Spanish, German, French, Italian, Dutch (for the Australian platform, other languages may be supported by the US platform). |
| Target Size | Enterprise health systems. |
| Compliance | |
| BAA Available | Unknown |
| HIPAA Compliant | Unknown |
| FDA Status |
1 UpDoc received FDA clearance (K253281) on December 23, 2025, for UpDoc V1.0, a prescription software medical device for insulin management in adults with type 2 diabetes. It is the first FDA-cleared clinical AI platform built for real-time patient care delivery and intelligent care coordination that uses patient-facing large language models. |
| SOC 2 | Unknown |
| GDPR | Unknown |
| Integrations | |
| EHR | Not specified |
| Specialties | Endocrinology, Family Medicine, Internal Medicine |
Social Proof
| Customers | unknown |
| Notable | Backed by Mayo ClinicEli Lilly & The American Diabetes Association |
What the Web Says
UpDoc (updoc.ai) receives mixed reviews. Many users praise its speed, convenience, and ease of access for routine medical needs like certificates and prescriptions, highlighting the professionalism of the medical staff. However, a significant number of complaints revolve around billing practices, particularly unauthorized subscription enrollments, and a non-responsive customer support system.
Overall: MixedStrengths
- Exceptional speed and convenience for consultations and obtaining medical documents.
- User-friendly interface and easy navigation.
- Professional, caring, and efficient medical staff.
- Provides accessible healthcare, especially beneficial for those in rural areas or with limited access to in-person doctors.
- Offers a wide range of telehealth services, including prescriptions, referrals, and various consultations.
- FDA-cleared AI platform designed to support doctors in chronic disease management and care coordination.
Limitations
- Frequent complaints about unauthorized subscription charges and misleading payment options.
- Non-existent or unresponsive customer service, making it difficult to resolve billing issues or other problems.
- Difficulty in canceling subscriptions, with some users being held to long contracts.
- Doctors on the platform cannot be selected, preventing continuity of care.
- Higher costs for priority or specialized consultations compared to some other telehealth providers.
- Some doctors working for UpDoc reportedly receive a very small portion of the consultation fee, raising concerns about the platform's practices.
Based on reviews from: ProductReview.com.au, updoc.ai, Apple App Store, MediCompare, Reddit (r/ausjdocs, r/australia, r/AskAnAustralian), Trustpilot, G2, Capterra, Morningstar
Last updated: 2026-06-29
Ratings & Reviews
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Press & Coverage
PR Newswire
UpDoc Debuts First FDA-Cleared Clinical AI Platform Built for Real-Time Patient Care Delivery and Intelligent Care Coordination
UpDoc announced FDA clearance for the first Software as a Medical Device (SaMD) that utilizes patient-facing large language models for clinical AI, combined with initial deployments at four leading health systems. The company has also secured $18 million in seed financing to scale its clinical AI platform.
2026-06
Daily AI Brief
UpDoc Receives FDA Clearance for Clinical AI Platform
UpDoc has received FDA clearance for its Software as a Medical Device, which is the first to use patient-facing large language models for clinical care delivery. The platform is being deployed at four major health systems and has secured $18 million in seed funding.
2026-06
Second Opinion
Updoc's FDA Win Raises the Stakes for Health AI Rivals
UpDoc's clinical AI platform, which combines physician-led medicine with AI for primary care, received FDA authorization to adjust insulin doses for Type 2 diabetes patients. Cleveland Clinic will pilot the program, where UpDoc's AI will follow up with patients, review glucose levels, and adjust medication.
2026-06
Innolitics
First FDA-Cleared AI Agent and LLM Enabled Device Confirmed
UpDoc announced FDA clearance for what it describes as the first clinical AI platform for real-time patient care, utilizing patient-facing large language models. The FDA's public database shows clearance for UpDoc V1.0, a prescription SaMD for insulin management in adults with type 2 diabetes, cleared in December 2025.
2026-06
RevCycleAI
UpDoc Gets First FDA Clearance for Agentic Clinical AI u2014 What It Means for RCM
UpDoc received FDA clearance for its agentic clinical AI platform, which can autonomously adjust medications, order labs, and document in EHRs without scheduled visits. This clearance confirms regulatory approval for patient-facing agentic AI in clinical use, opening new revenue opportunities for autonomous between-visit care.
2026-06
BioWorld
Updoc patents AI-powered diabetes management platform
Updoc received a patent for its AI-powered, voice-based method for prescribing, managing, and administering medication for type 2 diabetes. This follows successful clinical trial results published in JAMA Network Open in December 2023, where an AI-enabled smart speaker managed medication for patients.
2025-04
PR Newswire
UpDoc Debuts the World's First AI Assistant That Manages Medication Prescriptions and Chronic Conditions
UpDoc exited stealth mode, announcing a strategic funding round led by Polaris Partners with participation from Oxeon Partners, Eli Lilly & Company, and Mayo Clinic. The company offers a conversational AI platform that manages medication prescriptions and chronic conditions, building on research from Stanford Medicine.
2024-01
PMC (JAMA Network Open)
Evaluating the Impact of Artificial Intelligence (AI) on Clinical Documentation Efficiency and Accuracy Across Clinical Settings: A Scoping Review
This scoping review evaluates the impact of AI technologies, such as natural language processing, speech recognition, and machine learning, on the accuracy and efficiency of clinical documentation across various clinical settings. The review highlights improvements in documentation and reduced clinician workload, but also raises challenges regarding error management, legal liability, and EHR integration.
2024-11
Frequently Asked Questions
UpDoc is a clinical decision support (CDS) tool designed to assist physicians. It integrates by providing real-time, evidence-based recommendations and alerts directly within your electronic health record (EHR) system, aiming to streamline decision-making at the point of care.
UpDoc maintains compliance by regularly updating its knowledge base with the latest medical guidelines, evidence-based research, and regulatory standards. Its algorithms are designed to flag potential deviations from best practices and provide references to support its recommendations, aiding in audit readiness and adherence to quality metrics.
Potential limitations include the inability to account for every unique patient presentation or the nuances of complex comorbidities. UpDoc addresses this by providing recommendations as support, not mandates, emphasizing that the physician's clinical judgment remains paramount. It also offers mechanisms for feedback to continuously refine its algorithms and content.
UpDoc differentiates itself through its intuitive user interface, its focus on actionable insights, and its robust integration capabilities with various EHR systems. While other systems may offer similar features, UpDoc aims for a balance of comprehensive data and user-friendly presentation to minimize alert fatigue and maximize utility.
UpDoc offers a tiered pricing structure that accommodates both individual practitioners and larger healthcare systems. Pricing is typically based on factors such as the number of users, the scope of integrated features, and the level of support required. Specific details can be obtained through a direct consultation with our sales team to tailor a plan to your practice's needs.
Yes, UpDoc offers a degree of customization to align with specific specialty needs and preferred treatment protocols. While its core knowledge base is broad, certain modules and alert parameters can be configured to reflect the unique requirements of different medical disciplines or institutional guidelines, allowing for a more personalized CDS experience.
UpDoc provides comprehensive training and ongoing support to ensure seamless adoption and effective use. This includes initial onboarding sessions, access to a library of educational resources, and dedicated technical support. Regular updates and webinars are also provided to keep users informed of new features and best practices.
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| Last Verified: 2026-07-03 | First Added: 2026-06-28