Here’s how to replace all instances of TAB in a file input_file by, say comma (,), using sed
$ sed 's/<TAB>/,/g' input_file
But what is <TAB> above? On Linux systems you may just type \t (which is the regular expression for TAB) in place of <TAB>. However, on some other systems (e.g., OSX with FreeBSD) it does not work. In cases where it doesn’t work, invoke <TAB> by hitting Control+v followed by the TAB key. This may alternatively be achieved by hitting Control+v followd by Control+i, as well.
References: ATOzTOA, Stack Overflow.