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A new study reports that the PACAP signaling pathway is independent from the CGRP pathway, confirming the promise of PACAP as a drug target for migraine treatment.
The largest genome-wide association study so far reveals new variants associated with migraine risk, including variants linked to specific migraine subtypes.
Anne-Maree Kelly discusses her journey to emergency medicine and the challenges of managing migraine and other headache disorders in an emergency department setting.
New findings in mice show that CGRP activates Schwann cells to sensitize trigeminal neurons, leading to migraine-like pain.
In this interview, Professor Nahman-Averbuch discusses her work, what it’s like to launch a new lab, and her advice for young investigators.
A new prospective study documents a direct relationship between ACEs and migraine, independent of depression or anxiety.
A new trigeminal ganglia cell atlas in mice and people highlights the multiple cell types – both neuronal and non-neuronal – that are involved in migraine. The findings hold promise for the development of new migraine treatments.
Dr. Shapiro discusses how he got into migraine research, the problems of migraine stigma and research underfunding, the use of CGRP drugs, and, interestingly, why migraine may actually be protective against COVID.
New research extends upon the Global Burden of Disease study, finding that the prevalence of migraine has increased over time.
PL37, which inhibits the enzymes that degrade enkephalins, reduces migraine pain in rats.