CONFERENCE
Program
WHAT THE PROGRAM OFFERS
The ISC Conference Program brings together international speakers and offers diverse perspectives from scientists, researchers, and industry leaders. It covers key topics in high performance computing, artificial intelligence and quantum computing. The program is presented in various formats to maximize knowledge exchange and community engagement.
KEYNOTES
The three ISC Keynote presentations offer unique insights each day, featuring renowned experts in HPC, AI and IT.
OPENING KEYNOTE
Professor in Computer Engineering, TUM & Member of the Board of Directors at LRZ, Germany
HPC: A Heterogeneous Future
High performance computing (HPC) has long been driven by relentless demand for more computational power, enabling breakthroughs across science and engineering. For decades, Moore’s Law and Dennard Scaling provided a predictable path for performance growth but these trends have slowed dramatically, exposing fundamental challenges that go beyond transistor density. Issues such as data movement, memory bandwidth, and energy efficiency have become dominant bottlenecks, making incremental improvements in raw computational power insufficient. GPUs, while powerful, are not a fundamental departure from traditional architectures. As a result the need for transformative innovation has never been greater.
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The post-Moore era calls for a paradigm shift that pushes algorithmic advances, but also novel hardware and software approaches. Emerging technologies – quantum computing, neuromorphic architectures, photonics, and others – offer promising acceleration capabilities, but each introduces its own ecosystem, challenges and complexity. To harness these innovations effectively, HPC must evolve toward integrated, heterogeneous environments built on top of unified software stacks that ensure programmability, portability, and accessibility for domain scientists.
This keynote will showcase examples of emerging technologies and their integration into the HPC ecosystem. A concrete case will highlight quantum acceleration through an HPC-QC software stack and hybrid workflows. Building on this, the talk will outline strategies for creating a unified, heterogeneous environment that turns diversity in architectures – from quantum to neuromorphic – into a strength rather than a barrier.
ABOUT MARTIN SCHULZ
Martin Schulz is a Full Professor and Chair of Computer Architecture and Parallel Systems at the Technical University of Munich (TUM) and serves on the board of directors at the Leibniz Supercomputing Centre (LRZ). His research focuses on high performance computing, including parallel and distributed architectures, performance modeling and analysis, programming paradigms and tools, and power-aware computing. He is also actively exploring emerging technologies, including quantum computing and its integration into HPC systems.
MIDWEEK KEYNOTE
Associate Professor of Biomedical Sciences and Biomedical Engineering at Duke University
HPC for Vascular Digital Twins
Digital twin technology is reshaping healthcare by enabling patient-specific, physics-based models that move medicine from reactive treatment toward proactive and predictive care. This talk focuses on vascular digital twins that integrate medical imaging, physiological data, and large-scale blood flow simulation to create personalized representations of the circulatory system. These models support noninvasive assessment of vascular disease and extend beyond snapshot analyses to capture how physiology evolves over time.
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Achieving this vision introduces substantial computational challenges. Longitudinal vascular digital twins require sustained, high-fidelity simulation across thousands to millions of cardiac cycles, management of massive multimodal data sets, and rapid analysis suitable for clinical workflows. I will discuss how GPU-accelerated supercomputing and extreme-scale parallelism make this class of modeling tractable, enabling efficient simulation, data reduction, and interactive analysis at scale. The talk will also highlight how continuous data from wearable sensors and immersive visualization technologies can be coupled with large-scale digital twins to support an emerging paradigm in which time-integrated physiological dynamics inform early detection, risk stratification, and proactive healthcare. Together, these advances illustrate how modern supercomputing systems are transforming the modeling and application of human physiology.
ABOUT AMANDA RANDLES
Amanda Randles is the Alfred Winborne Mordecai and Victoria Stover Mordecai Associate Professor of Biomedical Sciences and Biomedical Engineering at Duke University, where she also serves as Director of the Duke Center for Computational and Digital Health Innovation. Her research focuses on the development of patient-specific digital twin models that integrate high performance computing, machine learning, and multiscale biophysical simulations to enable proactive diagnosis and treatment of diseases ranging from cardiovascular disease to cancer. Her contributions have been recognized with the ACM Prize in Computing, the NIH Pioneer Award, the NSF CAREER Award, the ACM Grace Hopper Award, the Jack Dongarra Early Career Award, and the Sony and Nature Women in Technology Award. Randles received her Ph.D. in Applied Physics from Harvard University, an M.S. in Computer Science from Harvard, and a B.A. in Computer Science and Physics from Duke. Prior to graduate school, she worked as a software engineer at IBM on the Blue Gene supercomputing team.
CLOSING KEYNOTE
Research Professor Emeritus, University of Tennessee & Distinguished Research Staff Member, ORNL, USA
HPC IN TRANSITION
High performance computing (HPC) is entering a decisive transition driven by forces that are largely external to traditional scientific HPC. The economics of artificial intelligence (AI) and hyperscale cloud now shape leading-edge silicon, system architectures, and software ecosystems, while energy and data movement have become the dominant constraints on performance, facility design, and long-term sustainability. This talk examines how these dynamics shift HPC’s center of gravity from a primarily FP64, node-centric worldview toward accelerator-heavy, rack-scale, and workflow-defined systems.
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We argue that the next era of scientific capability will be measured less by peak floating-point rates and more by time-energy-fidelity trade-offs across end-to-end pipelines. The most plausible path to “effective zettascale” is not brute-force FP64, but certified mixed-precision algorithms, communication-avoiding methods, AI-augmented reduced-order models, and hybrid AI+simulation workflows with rigorous error control and uncertainty quantification. We also outline an emerging reference architecture for platforms comprising integrated simulation, AI, and data/workflow partitions, linked and coordinated across multiple separate resources with secure cloud resources and instruments.
ABOUT JACK DONGARRA
Jack Dongarra specializes in numerical algorithms in linear algebra, parallel computing, the use of advanced computer architectures, programming methodology, and tools for parallel computers. He holds appointments at the University of Manchester and the University of Tennessee, where he founded the Innovative Computing Laboratory. He is a Fellow of the ISC, AAAS, ACM, IEEE, and SIAM; a foreign member of the British Royal Society and a member of the U.S. National Academy of Sciences and the U.S. National Academy of Engineering. He received the 2021 ACM A.M. Turing Award for his pioneering contributions to numerical algorithms and software that have driven decades of extraordinary progress in computing performance and applications.
TOPICS
TOPICS
The program is built around topic areas that reflect the key challenges and innovations in HPC, AI, and quantum computing. They provide the framework for both invited and contributed sessions.
Click on a topic area to view details.
System Architecture & Hardware Components
- Composable Disaggregated Infrastructure
- Data Center Infrastructure and Cooling
- Emerging Computing Technologies
- Energy Efficiency and Sustainability
- Extreme-scale Systems
- Heterogeneous System Architectures
- Memory Technologies and Hierarchies
- Networking and Interconnects
- Post Moore Computing
- Storage Technologies and Architectures
Programming Environments & System Software
- Compiler and Tools for Parallel Programming
- Cybersecurity in HPC and AI
- Energy Management
- File Systems
- HPC in the Cloud and HPC Containers
- Parallel Programming Languages
- Resource Management and Scheduling
- Runtime Systems for HPC
- System and Performance Monitoring
Algorithms & Performance
- Mixed Precision
- Novel Algorithms
- Optimizing for Energy and Performance
- Parallel Numerical Algorithms
- Performance and Resource Modeling
- Performance Measurement
- Performance Tools and Simulators
Applications & Use Cases
- Application Workflows for Discovery
- Bioinformatics and Life Sciences
- Chemistry and Materials Science
- Earth, Climate and Weather Modeling
- Engineering
- Geosciences
- Industrial Use Cases of HPC, ML and QC
- Physics
- Renewable Energy
- Visualization and Virtual Reality
Machine Learning & AI
- AI Applications powered by HPC Technologies
- AI Factories
- Digital Twins and ML
- High-Performance Data Analytics
- HPC Simulations enhanced by Machine Learning
- HW and SW Design for Scalable Machine Learning
- Large Language Models and Generative AI in HPC
- ML Model Optimization
- ML Systems and Frameworks
- Sovereignty in AI
Quantum Computing
- Integration of Quantum Computing and HPC
- Quantum Computing Basics and Theory
- Quantum Computing Technologies and Architectures
- Quantum Computing Use Cases
- Quantum Error Correction
- Quantum Machine Learning
- Quantum Program Development and Optimization
- Simulating Quantum Systems
Community & HPC
- Community Engagement
- Development of HPC Skills
- Diversity and Inclusion
- Education and Training
Program Chair
Director, HPC Software Research Area & Manager, Workflows and Distributed Computing Group, BSC, Spain
Program Deputy Chair
Professor, Supercomputing Research Center, Institute of Integrated Research, Institute of Science Tokyo, Japan
PROGRAM CHAIR & DEPUTY
“In 2026, ISC will continue to connect the dots: uniting HPC, AI, quantum and cloud for groundbreaking research from engineering to life sciences, all while championing sustainability as the cornerstone of future computing power.”
Rosa M. Badia
ABOUT ROSA M. BADIA
Rosa M. Badia holds a PhD in Computer Science (1994) from the Technical University of Catalonia (UPC). She has recently been appointed director of the HPC software research area and she is the manager of the Workflows and Distributed Computing research group, both roles at the Barcelona Supercomputing Center (BSC, Spain).
Her research has contributed to parallel programming models for multicore and distributed computing. Recent contributions have focused in the area of the digital continuum, proposing new programming environemnts and software environment for edge-to-cloud, as well as for the support of hybrid quantum-classic workflows. The research is integrated in PyCOMPSs/COMPSs, a parallel task-based programming distributed computing framework, and its application to developing large heterogeneous workflows that combine HPC, Big Data, and Machine Learning. The group is also doing research around the dislib, a parallel machine learning library parallelized with PyCOMPSs. Dr Badia has published more than 200 papers on her research topics in international conferences and journals. She has been very active in projects funded by the European Commission and in contracts with industry. In particular, she was the PI of the EuroHPC JU project eFlows4HPC. She is the chair of the ACM Europe Council since beginning of 2022, a member of the EuroHPC JU RIAG and a member of HiPEAC Network of Excellence.
She received the Euro-Par Achievement Award 2019 for her contributions to parallel processing, the DonaTIC award, category Academia/Researcher in 2019 and the HPDC Achievement Award 2021 for her innovations in parallel task-based programming models, workflow applications and systems, and leadership in the high performance computing research community. Since 2023 she is a member of the Institut d’Estudis Catalans (Catalan academy).
ABOUT RIO YOKOTA
Rio Yokota is a Professor at the Supercomputing Research Center, Institute of Integrated Research, Institute of Science Tokyo. He also leads the AI for Science Foundation Model Research Team at RIKEN Center for Computational Science. His research interests lie at the intersection of high performance computing, machine learning, and linear algebra. He has been optimizing algorithms on GPUs since 2007, and was part of a team that received the Gordon Bell prize in 2009 using the first GPU supercomputer. More recently, he has been leading distributed training efforts on Japanese supercomputers such as ABCI, TSUBAME, and Fugaku. He is the co-developer of the Japanese LLM Swallow, and LLM-jp. He is also involved in the organization of multinational collaborations such as ADAC and TPC.
A WIDE RANGE OF PROGRAM ELEMENTS
From keynotes to tutorials, the ISC Conference Program brings together academia, industry, and government.
A WIDE RANGE OF PROGRAM ELEMENTS
From keynotes to tutorials, the ISC Conference Program brings together academia, industry, and government.
INVITED PROGRAM
Explores HPC and adjacent technology trends, drawing insights from researchers worldwide.
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Keynotes
Notable speakers on trends and future outlook
→ View Keynote speakers -
Panels
Direct interaction with the audience -
Invited Talk
Insights from "hand-picked" experts -
HPC Around the World
Regional developments and emerging markets- Europe
- Africa, Latin America & Middle East
- Asia-Pacific
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Walking Talks
Guided exhibition tours by tech experts
→ Learn more
CONTRIBUTED PROGRAM
Submissions from researchers at all career levels create a diverse and rewarding program for the community.
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Research Paper
Presents original work to peers
→ Learn more -
Research Poster
Showcases the latest results and innovations
→ Learn more -
Project Poster
Shares ongoing collaborative projects
→ Learn more -
Women in HPC Poster
Showcases research by early-career women
→ Learn more -
Birds of a Feather
Informal discussions on niche topics
→ Learn more -
Tutorials
Comprehensive hands-on introductions
→ Learn more → Accepted Tutorials -
Workshops
Expert-led sessions with group work
→ Learn more → Accepted Workshops
VENDOR PROGRAM
Commercial organizations showcase their offerings and strategies, providing users with insight into current and future solutions.
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Vendor Roadmaps
Milestones and future directions -
Vendor Showdown
Product demos and expert Q&A -
HPC Solutions Forum
Strategies and technological advances -
First-Time Exhibitor Pitch
New exhibitors in one minute
STUDENT PROGRAM
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Student Volunteer Program
Volunteers support the conference and receive free access to tutorials, sessions, workshops, the exhibition, and selected evening events.
→ Learn more -
Student Cluster Competition
International student teams design and run cluster systems in real time, competing for the highest performance while demonstrating innovation and teamwork.
→ Learn more
PROGRAM AT A GLANCE
The Invited Program Committee (IPC) ensures that all relevant topic areas in HPC systems and applications are addressed at ISC 2025.
MEET THE INVITED PROGRAM SPEAKERS
Get to know some of the experts shaping the ISC Invited Program.
Martin Schulz: Leading Supercomputing into the Post-Moore Era
Jack Dongarra: The Mathematician Who Helped Define Modern Supercomputing
ISC 2025 KEYNOTE SPEAKERS
Opening Keynote
MARK PAPERMASTER
AMD Chief Technology Officer & Executive Vice President, USA
Midweek Keynote
BJORN STEVENS
Director of Climate Physics Department, Max Planck Institute for Meteorology Hamburg, Germany
Closing Keynote
YUTONG LU
Director, National Supercomputing Center, Guangzhou & Shenzhen, China
HELP SHAPE THE INVITED PROGRAM!
ISC encourages the community to take part in shaping the Invited Program. Share your nominations for speakers, panelists and chairs, especially talented early-career individuals, including women and researchers from underrepresented regions, who deserve to be recognized on a global stage.
AWARDS AT ISC 2026
ISC High Performance bestows awards annually to recognize research excellence by individuals and research groups from the global HPC communities.
JACK DONGARRA EARLY CAREER AWARD
An annual award honoring outstanding early-career contributions in HPC, commemorating Professor Jack Dongarra.
The award includes a certificate of recognition and a cash prize of € 5,000.
HANS MEUER AWARD
Recognizing the best research paper at ISC, the award honors Dr. Hans Meuer, former ISC chair and co-founder of the TOP500 project.
The Award includes a certificate and a cash prize of € 3,000.
BEST STUDENT PAPER AWARD
Honors the most outstanding student paper presented at ISC.
The award includes a cash prize of € 1,000, kindly sponsored by Jeff Hammond.
RESEARCH POSTER AWARD
Recognizes the most outstanding research posters presented at ISC.
Sponsored by Springer, the award includes cash prizes of €500 for first place, €300 for second place, and €200 for third place.
LAST YEAR'S WINNERS
JACK DONGARRA EARLY CAREER AWARD
Dr. Lin Gan of Tsinghua University has been selected as the recipient of the ISC 2025 Jack Dongarra Early Career Award.
The award committee recognized his exceptional contributions to developing scalable algorithms, optimizing performance, and pioneering FPGA-based frameworks for acceleration.
HANS MEUER AWARD
The paper selected as the winner of the ISC 2025 Hans Meuer Award is:
Towards a Unified Architectural Representation in HPCQC: Extending sys-sage for Quantum Technologies.
Authored by Durganshu Mishra, Stepan Vanecek, Jorge Echavarria, Xiaolong Deng, Burak Mete, Laura Schulz and Martin Schulz (Technical University Munich and Leibniz Supercomputing Center)
RESEARCH POSTER AWARD
The winners of the research poster awards are:
- 1st place:
DisCostiC: Digital Twin Performance Simulations Unlocking Hardware-Software Interplay
Authored by Ayesha Afzal, Georg Hager, Gerhard Wellein (Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Germany)
- 2nd place:
The Art of Process Pinning: Turning Chaos into Core Harmony
Authored by Thomas Breuer, Filipe Guimarães, Wolfgang Frings, Jens Henrick Göbbert, Carina Himmels, Chrysovalantis Paschoulas (Forschungszentrum Jülich, Germany)
- 2nd place:
ZeroSum: User Space Utility for Monitoring Hardware and Software Resources for HPC
Authored by Kevin Huck and Allen Malony (University of Oregon, USA)
INVITED PROGRAM COMMITTEE
The Invited Program Committee (IPC) ensures that all relevant topic areas in HPC systems and applications are addressed at ISC 2026. The IPC is supported by Program Chair Rosa M. Badia (BSC, Spain), Program Deputy Chair Rio Yokota (Institute of Science Tokyo, Japan), and the ISC Program Team.
System Architecture & Hardware Components
Programming Environments & System Software
Algorithms & Performance
Applications & Use Cases
Machine Learning & AI
Quantum Computing
HPC in Asia-Pacific (HPC Around the World)
HPC in Africa, Latin America & Middle East (HPC Around the World)
HPC in Europe (HPC Around the World)
HPC in Europe (HPC Around the World)
HPC Around the World (Europe)
CONTRIBUTED PROGRAM CHAIRS
The Contributed Program Chairs are the experts behind ISC 2026’s Contributed Program, fostering interdisciplinary understanding and enabling a productive technical exchange for the community.
Research Paper Chair
Research Poster Chair
Project Poster Chair
WHPC Poster Chair
Birds of a Feather Chair
Tutorial Chair
Workshop Chair
Proceedings Chair
STEERING COMMITTEE
The ISC 2026 Steering Committee provides guidance on the conference program and helps enhance the visibility, recognition, and growth of ISC within industry, research, and academia.
VIEW ALL MEMBERS
- Hartwig Anzt, Technical University of Munich, Germany (Tutorials Chair)
- Rosa M. Badia, Barcelona Supercomputing Center, Spain (Program Chair)
- Frank Baetke, European Open File Systems Association, Germany (ISC Fellow)
- Prasanna Balaprakash, Stealth AI Startup, USA (Invited Program Committee Topic Area Chair)
- Grey Ballard, Wake Forest University, USA (Proceedings Deputy Chair)
- Gianfranco Bilardi, University of Padova, Italy (Project Posters Chair)
- Serge Bogaerts, PRACE, Belgium
- Francieli Zanon Boito, Université de Bordeaux, France (Workshops Deputy Chair)
- Ron Brightwell, Sandia National Laboratories, USA (Invited Program Committee Topic Area Chair)
- Eleanor Broadway, University of Edinburgh, UK, (Women in HPC)
- Erin Carson, Charles University, Czech Republic (Proceedings Chair)
- Ewa Deelman, University of Southern California, USA (Project Posters Deputy Chair)
- Jack Dongarra, University of Tennessee, USA (ISC Fellow)
- Horst Gietl, Germany (ISC Fellow)
- Pauline Gounaud, EuroHPC Joint Undertaking, Luxemburg
- Alexander Heinlein, Delft University of Technology, The Netherlands (Tutorials Deputy Chair)
- Terence Hung, NSCC Singapore, Singapore (HPC Around the World Chair)
- Tanzima Islam, Texas State University, USA (Research Posters Chair)
- Hatem Ltaief, KAUST, Saudi Arabia (Research Papers Chair)
- Yutong Lu, Sun Yat-Sen University East Campus, China (ISC Fellow)
- Thomas Ludwig, Universität Hamburg & DKRZ, Germany (ISC Fellow)
- Satoshi Matsuoka, Riken Center for Computational Science, Japan (ISC Fellow)
- Sabine Mehr, GENCI, France (Invited Program Committee Topic Area Chair)
- Kathryn Mohror, Lawrence Livermore National Laboratory, USA (Invited Program Committee Topic Area Chair)
- Wolfgang Nagel, Technische Universität Dresden, Germany (ISC Fellow)
- Francesca Palumbo, University of Cagliari, Italy (BoF Deputy Chair)
- Manish Parashar, University of Utah, USA (Invited Program Committee Topic Area Chair)
- Arnab K. Paul, Birla Institute of Technology and Science, India (Workshops Chair)
- Horst Simon, ADIA Lab, Abu Dhabi (ISC Fellow)
- Estela Suarez, Juelich Supercomputing Center, Germany (Invited Program Committee Topic Area Chair)
- Carla Osthoff, Laboratório Nacional de Computação Científica, Brazil (HPC Around the World Chair)
- Thomas Sterling, Indiana University, USA (ISC Fellow)
- Erich Strohmaier, USA (ISC Fellow)
- Michela Taufer, The University of Tennessee, USA (Jack Dongarra Early Career Award Committee Chair)
- Carsten Trinitis, Technical University of Munich, Germany (BoF Chair)
- Richard Vuduc, Georgia Institute of Technology, USA (Research Paper Deputy Chair)
- Gerhard Wellein, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Germany (HPC Around the World Co-Chair)
Contact
MS. TANJA GRÜNTER
Conference Program Manager
Invited Program
Ms. MAREILE GRÜN
Conference Program Coordinator
Vendor Program
MS. ISABEL GRÄBNER
Conference Program Manager
Contributed Program
MR. GEORG HAGER
Contributed Program Advisor