I have the following requirements:
Django==1.11.6
boto3==1.4.7
django-storages==1.6.5
aws-xray-sdk==0.93
I want to store media files in an S3 bucket. To trace that I do:

if 'aws_xray_sdk.ext.django' in settings.INSTALLED_APPS:
    from aws_xray_sdk.core import patch_all
    patch_all()

After that, when I try to upload file to my site, a SegmentNotFoundException is raised.
If I do:

if 'aws_xray_sdk.ext.django' in settings.INSTALLED_APPS:
    from aws_xray_sdk.core import patch
    patch(['requests'])

then all is good, but, obviously, there are no traces for boto3.
The xray middleware is in the list of middleware classes, and the xray app is in the INSTALLED_APPS list.