We believe in a world where everyone has evidence-driven health, longevity guidance and access to the best longevity products and services.
This is why we created the FLTTM range of supplement products with ingredients supported by clinical studies conducted in humans and/or scientific evidence.
Reference #
Product
Ingredient
Paper Title
Publication
1
LONGEVITY
Niagen
Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults
Nature
−
"Consumption of 100, 300 and 1000 mg NR dose-dependently and significantly increased whole blood NAD+ (i.e., 22%, 51% and 142%) and other NAD+ metabolites within 2 weeks."
2
LONGEVITY
Niagen
Nicotinamide riboside supplementation does not alter whole-body or skeletal muscle metabolic responses to a single bout of endurance exercise
The Journal of Physiology
−
3
LONGEVITY
L-Ergothioneine
The Effect of Ergothioneine Supplementation on Cognitive Function and Other Health-Related Outcomes in Older Adults With Subjective Memory Complaints (Abstract)
Current Developments of Nutrition
−
"Both the ERG 10mg and 25mg groups showed dose-dependent increases in blood-plasma Ergothioneine levels and decreases in liver enzyme markers (AST and ALT; all p< .05)."
4
LONGEVITY
L-Ergothioneine
Ergothioneine Mitigates Telomere Shortening under Oxidative Stress Conditions
Journal of Dietary Supplements
−
"We cultured primary human fibroblasts... ergothioneine demonstrated beneficial effects by decreasing the rate of telomere shortening and preserving telomere length under oxidative stress conditions."
6
LONGEVITY
L-Ergothioneine
Ergothioneine and its prospects as an anti-ageing compound
Experimental Gerontology
−
"EGT was also coined as a ‘longevity vitamin’ as proposed in a triage theory where it can only be obtained through external sources similar to other vitamins and that it is responsible to play dual role: survival and longevity ..."
7
LONGEVITY
Resveratrol
Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review
MDPI
−
"...experimental studies have shown that resveratrol possesses many bioactivities and health benefits like antioxidant, anti-inflammatory, immunomodulatory effects..."
8
LONGEVITY
Resveratrol
Effects of Resveratrol Supplementation on Inflammatory Markers: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Clinical Therapeutics
−
"Available evidence from RCTs suggests that resveratrol supplementation significantly reduced TNF-a and hs-CRP levels."
9
LONGEVITY
Resveratrol
Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders—An Overview of Experimental Evidence
MDPI
−
"RES has demonstrated significant neuroprotective potential through its antioxidant properties, suppression of cell death, enhancement of mitochondrial function, and promotion of neuroplasticity..."
10
LONGEVITY
Resveratrol
Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study
Clinical Nutrition
−
"Regular supplementation with low-dose resveratrol can enhance cognition, cerebrovascular function and insulin sensitivity in postmenopausal women. This may translate into a slowing of the accelerated cognitive decline due to ageing and menopause, especially in late-life women"
13
LONGEVITY
Spermidine
Mechanisms of spermidine-induced autophagy and geroprotection
Nature Aging
−
"Many cellular effects caused by spermidine have been mechanistically linked to autophagy, a homeostatic, intracellular degradation and recycling mechanism. Autophagy enhancement harbors broad health-promoting potential and constitutes the molecular basis for several geroprotective strategies"
14
LONGEVITY
Spermidine
Spermidine delays aging in humans
Aging
−
"Based on current knowledge, these agents may slow down the general clock of the aging process, for instance by a global effect on cellular fitness..."
15
LONGEVITY
Spermidine
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
The Journal of Cell Biology
−
"At doses at which neither reseveratrol nor spermidine stimulated autophagy alone, these agents synergistically induced autophagy…"
16
COGNITION
Ginkgo Biloba
A double-blind, placebo controlled study of Ginkgo biloba extract (‘Tanakan’) in elderly outpatients with mild to moderate memory impairment
Current Medical Research and Opinion
−
"Statistical analysis of the data as compared to baseline suggests that Ginkgo biloba extract had a beneficial effect on cognitive function in this group of patients."
17
COGNITION
Ginkgo Biloba
A Placebo-Controlled, Double-blind, Randomized Trial of an Extract of Ginkgo Biloba for Dementia
JAMA
−
"EGb was safe and appears capable of stabilizing and, in a substantial number of cases, improving the cognitive performance and the social functioning of demented patients for 6 months to 1 year."
18
COGNITION
Ginkgo Biloba
Modulation of cognitive performance following single doses of 120 mg Ginkgo biloba extract administered to healthy young volunteers
Human Psychopharmacology
−
"The current study confirmed the previous observation of modestly improved memory performance following 120 mg of Gingko Biloba Extract (GBE).."
19
COGNITION
L-Ergothioneine
Ergothioneine and its prospects as an anti-ageing compound
Experimental Gerontology
−
"EGT was also coined as a ‘longevity vitamin’ as proposed in a triage theory where it can only be obtained through external sources similar to other vitamins and that it is responsible to play dual role: survival and longevity ..."
20
COGNITION
L-Ergothioneine
The Effect of Ergothioneine Supplementation on Cognitive Function and Other Health-Related Outcomes in Older Adults With Subjective Memory Complaints (Abstract)
Current Developments in Nutrition
−
"Both the ERG 10mg and 25mg groups showed dose-dependent increases in blood-plasma Ergothioneine levels and decreases in liver enzyme markers (AST and ALT; all p< .05)."
21
COGNITION
L-Ergothioneine
Are age-related neurodegenerative diseases caused by a lack of the diet-derived compound ergothioneine?
Free Radical Biology and Medicine
−
"Work by multiple groups has established that low ET levels in humans are associated not only with cognitive impairment/AD but also with other age-related conditions, including frailty, Parkinson's disease, vascular dementia, chronic renal disease, cardiovascular disease, and macular degeneration ..."
22
COGNITION
Taxifolin / Dihydroquercetin
Ingestion of taxifolin-rich foods affects brain activity, mental fatigue, and the whole blood transcriptome in healthy young adults: a randomized, double-blind, placebo-controlled, crossover study
Food & Function
−
"Taxifolin intake was shown to affect the brain activity of healthy young adults and demonstrated an antifatigue effect, thereby reducing subjective fatigue."
23
COGNITION
Taxifolin / Dihydroquercetin
New Perspectives of Taxifolin in Neurodegenerative Diseases
Current Neuropharmacology
−
"In central nervous system, TAX was verified to provide neuroprotection against neurodegeneration via reducing inflammatory responses and ROS production."
24
COGNITION
Taxifolin / Dihydroquercetin
Comparison of In Vitro and In Vivo Antioxidant Activities of Six Flavonoids with Similar Structures
Antioxidants
−
"The DPPH• and ABTS+ scavenging activities of Vitamin C were the lowest, compared with those of the six flavonoids (including taxifolin) (p < 0.05)."
25
COGNITION
Lutein
Effects of Lutein and Astaxanthin Intake on the Improvement of Cognitive Functions among Healthy Adults: A Systematic Review of Randomized Controlled Trials
Nutrients
−
"This systematic review (SR) showed that the 10 mg lutein per day for twelve months can lead to improvement of cognitive functions."
27
COGNITION
Lutein
Lutein Has a Positive Impact on Brain Health in Healthy Older Adults: A Systematic Review of Randomized Controlled Trials and Cohort Studies
Nutrients
−
Three intervention studies using MRI indicated that 10 mg lutein intake over 12 months had a positive impact on healthy older adults’ brain activities during learning, resting-state connectivity, and gray matter volumes. Four cross-sectional studies using MRI suggested that lutein was positively associated with brain structure and neural efficiency during cognitive tasks. Conclusion: Although only nine studies that used similar datasets were reviewed, this systematic review indicates that lutein has beneficial effects on healthy older adults’ brain health.
28
COGNITION
Caffeine + L-theanine
The combined effects of L-theanine and caffeine on cognitive performance and mood.
Nutritional Neuroscience
−
"The L-theanine and caffeine combination improved both speed and accuracy ... [and] in combination are beneficial for improving performance on cognitively demanding tasks."
29
COGNITION
Caffeine + L-theanine
L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness.
Appetite
−
"The combination of L-theanine and caffeine significantly improved attention on a switch task as compared to the placebo." + “The present results suggest that 97 mg of L-theanine in combination with 40 mg of caffeine helps to focus attentionduring a demanding cognitive task.”
31
MUSCLE
PeptiStrong
Enhanced strength and endurance following 8-weeks of Vicia faba hydrolysate supplementation combined with resistance exercise in healthy untrained males and females.
BMJ Nutrition (pre-published)
−
"This randomised, double-blind, placebo-controlled clinical trial demonstrated that PeptiStrong supplementation in conjunction with resistance exercise significantly improved strength and muscular endurance in healthy untrained males and females ..."
32
MUSCLE
PeptiStrong
Improved Strength Recovery and Reduced Fatigue with Suppressed Plasma Myostatin Following Supplementation of a Vicia faba Hydrolysate, in a Healthy Male Population
MDPI
−
"...NPN_1 supplementation improved strength recovery, reduced fatigue and suppressed myostatin expression in a healthy male population following EIMD [exercise-induced muscle damage]."
33
MUSCLE
PeptiStrong
Vicia faba Peptide Network Supplementation Does Not Differ From Milk Protein in Modulating Changes in Muscle Size During Short-Term Immobilization and Subsequent Remobilization, but Increases Muscle Protein Synthesis Rates During Remobilization in Healthy Young Men
The Journal of Nutrition
−
"Muscle mass and strength decrease during short periods of immobilization and slowly recover during remobilization. Recent artificial intelligence applications have identified peptides that appear to possess anabolic properties in in vitro assays and murine models ... compared with milk protein supplementation on muscle mass and strength loss during limb immobilization and regain during remobilization."
34
MUSCLE
Creatine
International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine
Journal of the International Society of Sports Nutrition
−
"... creatine stores can generally be maintained by ingesting 3–5 g/day, although some studies indicate that larger athletes may need to ingest as much as 5–10 g/day in ... due to the health benefits of creatine, individuals should consume about 3 g/day of creatine in their diet particularly as one ages."
35
MUSCLE
Creatine
Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation
Journal of Clinical Medicine
−
"... evidence indicates that creatine supplementation, with and without resistance training, has possible anti-sarcopenic and anti-dynapenic effects. Specifically, creatine supplementation increases aging muscle mass and strength (upper- and lower-body) ... Creatine supplementation has shown potential to enhance bone mineral in some but not all studies, and seems to affect the activation of cells involved in both bone formation and resorption."
36
MUSCLE
Creatine
Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: A meta-analysis.
Journal of Sports Medicine
−
"We conducted a systematic review and meta-analysis of randomized controlled trials of creatine supplementation during resistance training in older adults ... Twenty-two studies were included in our meta-analysis with 721 participants (both men and women; with a mean age of 57–70 years across studies) randomized to creatine supplementation or placebo during resistance training 2–3 days/week for 7–52 weeks. Creatine supplementation resulted in greater increases in lean tissue mass ... chest press strength ... and leg press strength."
37
MUSCLE
Creatine
Effects of Creatine Supplementation during Resistance Training Sessions in Physically Active Young Adults
Nutrients
−
"The creatine group experienced a significant increase (p < 0.05) in leg press, chest press and total body strength and leg press endurance with no significant changes in the PLA group. Both groups improved total body endurance over time (p < 0.05), with greater gains observed in the creatine group. In conclusion, creatine ingestion during resistance training sessions is a viable strategy for improving muscle strength and some indices of muscle endurance in physically active young adults."
38
MUSCLE
Creatine
Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations
Nutrients
−
"Augmenting intramuscular creatine stores either by creatine loading or daily supplementation over several days leads to increased concentrations of intramuscular creatine and PCr. Increases in these substrates are associated with an attenuation of ATP degradation, heightened ATP production, and an increase in energetic output during activities involving intermittent, high-intensity, short bouts of exercise. Additionally, creatine supplementation shows promise in facilitating recovery following exercise-induced muscle damage and potentially as an aid during post-injury rehabilitation. "
39
MUSCLE
Creatine
Creatine supplementation and endurance performance: surges and sprints to win the race
Journal of the International Society of Sports Nutrition
−
"Overall, creatine supplementation increases time to exhaustion during high-intensity endurance activities, likely due to increasing anaerobic work capacity. In terms of time trial performances, results are mixed; however, creatine supplementation appears to be more effective at improving performances that require multiple surges in intensity and/or during end spurts, which are often key race-defining moments. Given creatines ability to enhance anaerobic work capacity and performance through repeated surges in intensity, creatine supplementation may be beneficial for sports, such as cross-country skiing, mountain biking, cycling, triathlon, and for short-duration events where end-spurts are critical for performance, such as rowing, kayaking, and track cycling."
40
MUSCLE
L-Glutamine
Supplementation of L-glutamine enhanced mucosal immunity and improved hormonal status of combat-sport athletes
Journal of the International Society of Sports Nutrition
−
"Three-week supplementation of L-glutamine after intensive training enhanced the mucosal immunity, improved hormonal status and reduced the rate of URTI of combat-sport athletes while feelings of well-being were also enhanced. Therefore, L-glutamine would be beneficial for the sports performance and recovery of athletes."
41
MUSCLE
L-Glutamine
L-Glutamine Supplementation Improves the Benefits of Combined-Exercise Training on Oral Redox Balance and Inflammatory Status in Elderly Individuals
Oxidative Medicine and Cellular Longevity
−
"In conclusion, the elderly subjects from the CET group showed a better inflammatory response and redox balance and, for the first time, it was shown that daily supplementation with Gln for 30 days can improve these benefits with putative association with a healthy aging."
42
MUSCLE
L-Glutamine
Effect of Glutamine Supplementation on Muscular Damage Biomarkers in Professional Basketball Players
Nutrients
−
"To this end, the present report aimed to study if oral L-glutamine supplementation could attenuate muscle damage in a group of players of a mainly eccentric sport discipline such as basketball ... Altogether, the results indicate that glutamine could help attenuate exercise-induced muscle damage in sport disciplines with predominantly eccentric actions."
43
MUSCLE
Electrolyte Blend (120mg Sodium Chloride, 248mg Potassium, 43 mg Calcium)
The Effect of Electrolytes on Blood Pressure: A Brief Summary of Meta-Analyses
Pubmed
−
While the specific blend (120mg Sodium Chloride, 248mg Potassium, 43mg Calcium) is not directly studied in the provided research, the inclusion of these key electrolytes is supported by clinical evidence for their roles in hydration, muscle function, and overall health.
44
MUSCLE
Magnesium
Can Magnesium Enhance Exercise Performance?
Nutrients
−
"A number of studies evaluated the association between Mg status/supplementation and exercise performance and found that the need for Mg increased as individuals’ physical activity level went up ..."
45
MUSCLE
Magnesium
Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: a randomized controlled trial
The American Journal of Clinical Nutrition
−
"Daily magnesium oxide supplementation for 12 wk seems to improve physical performance in healthy elderly women. These findings suggest a role for magnesium supplementation in preventing or delaying the age-related decline in physical performance."
46
MUSCLE
Zinc
Plasma/Serum Zinc Status During Aerobic Exercise Recovery: A Systematic Review and Meta-Analysis
Sports Medicine
−
"The present analysis showed that serum zinc levels decrease significantly during exercise recovery, compared to pre-exercise levels. This extends our previous report of an increase in serum zinc immediately after exercise. We postulate that the exercise-induced fluctuations in zinc homeostasis are linked to the muscle repair mechanisms following exercise."
47
MUSCLE
Zinc
The immune system and the impact of zinc during aging
Immunity & Aging
−
"Many studies confirm a decline of zinc levels with age. Most of these studies do not classify the majority of elderly as zinc deficient, but even marginal zinc deprivation can affect immune function. Consequently, oral zinc supplementation demonstrates the potential to improve immunity and efficiently downregulates chronic inflammatory responses in the elderly."
48
MUSCLE
Zinc
Association of Zinc Intake With Risk of Impaired Physical Function and Frailty Among Older Adults
The Journals of Gerontology: Series A
−
"Higher zinc intake was prospectively associated with a lower risk of ILEF and frailty among older adults, suggesting that adequate zinc intake, which can be achieved through a healthy diet, may help preserve physical function and reduce the progression to frailty."
