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“Early detection of colon cancer is one of the two lowest pieces of fruit on the delaying death pathway.” – Peter Attia
Peter Attia was on 60 minutes recently, so I thought it was a good time again to post some of his recommendations.
I also thought these notes on his book were great: https://www.grahammann.net/book-notes/outlive-peter-attia
Some takeaways to highlight:
Here is a version of Peter Attia’s Longevity Screening Schedule by Age (via ChatGPT) – more research is needed!
Metabolic Health
Fitness & Body Composition
Cancer & General Screening
Additional Health Data
Metabolic / Cardiovascular
Cancer
Fitness / Frailty
Other
The Two Low-Hanging Fruit
Cardiovascular Screening
Metabolic Health
Cancer Screening
Fitness / Strength / Frailty
Sleep
Cardiovascular
Metabolic
Cancer
Hormones & Organ Function
Functional Health
Cardiovascular
Metabolic
Cancer
Bone, Frailty & Function
Cognitive & Sensory Health
Additional clips from 60 minutes:
Update Nov 20: Study on risks of Ultra Processed Foods (UPF)
https://www.bbc.com/news/articles/cy4pjjzd784o
Action is needed now to reduce ultra-processed food (UPF) in diets worldwide because of their threat to health, say international experts in a global review of research.
They say the way we eat is changing – with a move away from fresh, whole foods to cheap, highly-processed meals – which is increasing our risk of a range of chronic diseases, including obesity and depression.
Writing in The Lancet, the researchers say governments need “to step up” and introduce warnings and higher taxes on UPF products, to help fund access to more nutritious foods.
Additional therapies I’m monitoring:
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AI progress marches on, here are some useful videos and links:
0:00 Introduction & Going Live 0:43 Meet Palmer: From Baseball to Blockchain to AI 2:24 Overview: AI Development Workflows 3:57 The New Project Setup Document 5:02 Document #1: Project Overview 5:22 Document #2: User Flow 5:45 Document #3: Tech Stack (Most Important) 6:03 Document #4: UI and Theme Rules 6:22 Document #5: Project Rules 7:17 Document #6: Phase Documentation 8:05 Docs Folder Structure 12:36 Cursor Rules vs Cursor.rules File 14:27 User Rules Configuration 18:02 Q&A: Boilerplate vs Starting Fresh 18:50 Custom Modes in Cursor 23:35 Deep Dive: New Project Setup Steps 27:17 AI-First Codebase Design 29:37 Iterative Development with Checklists 35:08 Planning Outside the IDE 38:00 Building with Documents 39:50 Context Management 43:01 Rule Inclusion Hierarchy 45:15 Cursor Notepads Feature 49:30 Chat Management 52:02 Debugging Strategies 54:46 Learning from Errors 57:23 Checkpoint Management 58:51 Closing & Resources
Slides: https://docs.google.com/presentation/d/1kCNuSck8sRpeyaPg1ElgRsMXvweU9XfL1SjO1xUi9DQ/edit?usp=sharing
https://x.com/wadefoster/status/1930680089651425452 “Zapier is measuring PMs on AI fluencyYou only get Capable if you have good prompts & use AI for PRDs and research synth. This is the baseline

AI notes:
Based on the detailed text content about Shopify’s AI-first approach, here is a comprehensive list of practices you can apply at your company to leverage AI effectively and transform your engineering and broader teams:
Based on the provided text, here is a detailed list of all the AI tools, frameworks, platforms, and related technologies mentioned that Shopify uses or has experimented with:
12 years ago I posted speeches by Pierre Poilievre and Mark Carney, the two front runners to the current federal election. Both speeches focused on getting Canada’s house in order, so its interesting to reflect on them now.
I compared Mark Carney‘s speech ‘Growth in the age of deleveraging‘ (2011) with the Liberal party platform, using AI (o3), with some edits and added charts below:
| Liberal Party platform 2025 – Canada Strong: Unite. Secure. Protect. Build. † | “Growth in the Age of Deleveraging,” Mark Carney, Dec 12 2011 † | |
|---|---|---|
| Diagnosis of the problem | A hostile external shock: a U-S-led “unjustified trade war” that threatens jobs and sovereignty; domestic bottlenecks (inter-provincial barriers, weak capital formation, housing shortages). Liberal Party of Canada | A structural shock: the end of a 30-year “debt super-cycle” in the advanced world; households, firms and governments must shed leverage and cannot rely on debt-fuelled demand. Bank of Canada |
| Over-arching goal | Out-grow the shock: become “the strongest economy in the G-7” by catalysing C$500 bn in new investment over five years. Liberal Party of Canada | Out-adjust the shock: preserve Canada’s privileged fiscal/financial position and shift growth from household consumption to business investment and exports. Bank of Canada |
| Policy engine | Very activist fiscal policy—roughly C$150 bn in federal measures spanning: • internal-trade liberalisation, nation-building infrastructure, Arctic corridors • large housing build-out & GST cuts for first-time buyers • sector plans (auto, critical minerals, defence, AI); clean-energy grid • expanded public health care, youth mental-health fund, GBA+ lens on all spending. Liberal Party of CanadaLiberal Party of CanadaLiberal Party of Canada | Market-led rebalancing reinforced by: • tighter mortgage insurance rules to curb household borrowing • productivity-raising corporate investment, especially into fast-growing emerging markets • maintenance of a credible low-inflation monetary framework; prudent fiscal stance. Bank of Canada |
| View on debt & risk | Will run sizable deficits today on the argument that multipliers are high; claims the growth dividend will lower the debt ratio over time (no dynamic feedback baked into the tables). Liberal Party of Canada | Warns that “excess leverage” is the core risk; advanced economies face a “prolonged period of deleveraging.” Canada must not repeat others’ mistakes by letting easy capital fund consumption rather than capacity. Bank of CanadaBank of Canada |
| International posture | Defensive economic nationalism (buy Canadian, tougher Investment Canada Act) plus alliances on climate, Arctic security and Ukraine. Liberal Party of Canada | Calls for cooperative global rebalancing (G-20 Action Plan) and exchange-rate flexibility—emphasises openness to emerging-market demand rather than protectionism. Bank of Canada |
| Theme | Platform 2025 | Carney 2011 |
|---|---|---|
| Role of the state | Keynesian: Government is the prime mover—using procurement, tax credits, direct outlays and crown-backed loans to crowd-in private capital. | Liberal-market: Government’s role is to keep macro conditions stable; growth must come from firms reallocating capital, not from permanent public deficits. |
| Attitude toward leverage | Willing to increase federal debt today for long-run payoff; very little discussion of debt sustainability metrics beyond “lower ratio later.” | Debt is the binding constraint; warns that “cheap and easy capital” must not fund consumption and that even Canada’s households are over-extended. |
| Fiscal space vs. fiscal risk | Assumes room to borrow, pointing to Canada’s AAA rating; frames spending as a sovereignty shield. | Treats fiscal space as a precious buffer that must be preserved for shocks; sees excessive public debt abroad as a cautionary tale. |
| Social-policy footprint | Broad social program expansions (child-care, dental, pharmacare, disability justice) integral to growth narrative (“strong middle class = strong economy”). | Social programs largely outside the speech’s remit; focus is macro-financial, not distributive. |
| International economic strategy | Tilts toward managed trade (“All-in-Canada” supply chains, tighter screening of foreign takeovers) in reaction to U.S. tariffs. | Advocates cooperative multilateralism and open markets; no overt economic-nationalist measures. |
Back in 2011, Governor Carney argued that the post-crisis world demanded prudence and private-sector-led rebalancing: pay down debt, lift business investment, find new export markets, keep the state’s balance-sheet dry.
In 2025, the Liberal platform he now fronts adopts a nearly mirror-image response to a different shock: large-scale public investment and a more interventionist federal hand to defend sovereignty, accelerate clean growth, and cushion households.
Both documents share a core belief that productivity and diversified trade are Canada’s path to prosperity. What has flipped is the chosen vehicle—fiscal activism vs. fiscal restraint—and the perceived threat—external tariffs today vs. global leverage yesterday.
Debt Metric Recap:



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The alpha, your job as an AI practitioner, is to ask “What will everyone be doing in 1yr that I can do now?”
•Force yourself to use AI, think of how you can automate something when you’re doing it
•Don’t go for your old routine. Use AI and Low/NoCode. It won’t be convenient at first, but it’ll force you to spend most of your time doing what actually matters in the future?
•What’s your AI aha moment? ChatLLM? NotebookLM? Illuminate? Gemini 1.5 + Deep Research? Cursor? Bolt? ChatGPT? Etc…•
“If you’re an …. your goal should be to move to the forefront of what is made possible by AI and just ride that wave. A time like now when something is young and is blowing up but experts are few and best practices are ill-defined are when you can find absurd amounts of alpha. Honestly, the delta between what the current ….. knows and the forefront of AI is smaller than most assume, but I’m shocked at how few …… are working that direction. …. are too burned out from hype cycles that didn’t come to pass, but this time is different.”
“There is a MASSIVE CHASM between ai native and non ai native people that will be filled with LEARNING more than software.”
“”Vibe knowledge work” could mean a way of working where you rely on intuition, creativity, and AI assistance to manage, process, or generate knowledge, rather than getting bogged down in rigid structures or manual effort. Imagine using natural language to direct AI tools to research, summarize, or connect ideas for you—focusing on the big picture or the “vibe” of what you’re trying to achieve, like understanding a topic deeply or crafting a compelling argument. The AI would handle the tedious details (like sifting through data or formatting reports), while you steer it with high-level intent, maybe even through casual prompts or voice commands.”
@rowancheung
•Sam Altman on what you need to do to survive in the age of artificial intelligence.
•”You are about to enter the greatest golden age of human possibility…”
•To thrive in that world, the skills that matter most are:
•– Deep familiarity with the tools
•– Staying abreast of changes
•– Developing a great intuition for AI tools, where things are going, and how to make use of it
•– Resilience and the ability to learn things fast and evolve yourself with technology
•I know most of this stuff is a pretty big no-brainer for anyone paying attention, but here’s the takeaway:
•AI upskilling and keeping up with AI are possibly the most important skills in the world right now.
•And the most fascinating part is that new AI developments and tools come out so fast that everyone is constantly learning.
•I’ve been asked by few first year PhD about how to start LLM research on X, say long context modeling. My number one suggestion — though it seems a bit of unconventional — is *not* to read any papers related to long-context, but to talk to the model – Talk to the model about a text book, course slides, financial reports, novels, nonfictions, any long document you could find – Talk to the model for two whole weeks, from the morning first thing after opening up the laptop, to the evening last thing before going to the bed. – Ask every single question you could imagine, what is PCA? How does it compare to SVD? Which part of the book describes the two? What the book says exactly? – Talk to all the models you could access, GPT, Gemini, Claude, Llama … – Keep talking to the model for two whole weeks, no research, no paper, no arxiv, just talk to the model. – During the above process, continuously observe how the model behave, discover their problems, and think about why models could behave that way I found people who have gone through the above process have a fundamentally different level of understanding than people who just read papers
•If you want to do research on AI, or figure out how it can be used in your organization, the first step is talk to the models a lot. Use it for everything you do (within legal & ethical bounds). You don’t know what it does until you use it.
@johnrushx
•The Future of <Software Developer> profession:
•> software developer jobs will mainly become obsolete
•> product builders will replace them & be huge
•> code itself eventually will be abstracted far away by AI builders + component/block libraries + nocode/lowcode
•> the number of solo product builders will grow from less than a million to 10s of millions.
•> 1% of the best devs will be building these platforms & legacy/corporate/critical software
•> 99% will be forced to become “product builders”
•> most will ignore this until it’s too late and they’re out of their jobs with no skills to get a new one on same pay grade
•>> The best way to prepare for the change is to become a part-time indie hacker. Don’t quit your job; build and ship pet projects in the evenings and weekends.
•When you do so, don’t go for your old routine.
•Use AI and NoCode. It won’t be convenient at first, but it’ll force you to spend most of your time doing what actually matters in the future:
•> UX
•> ideations and validation
•> content creation
•> learning to win attention
•> translating pain points into products
•> training your eye on patterns
•> mastering productivity
•> social media
https://www.oneusefulthing.org/p/innovation-through-prompting
https://www.oneusefulthing.org/p/detecting-the-secret-cyborgs?r=i5f7
Four Questions to Ask About Your Organization.
So how can leaders start to think about the rapidly advancing nature of AI? The first thing they should do is use it. No amount of reading and research can substitute for spending 10 hours or so with a frontier model, learning what it can do. After getting familiar, companies should think about the following four questions:
1.What useful thing you do is no longer valuable? AI doesn’t do everything well, but it does some things very well. For many organizations, AI is fully capable of automating a task that used to be an important part of your organizational identity or strategy. AI comes up with more creative ideas than most people, so your company’s special brainstorming techniques may no longer be a big benefit. AI can provide great user journeys and personas, so your old product management approach is no longer a differentiator. Getting a sense of what AI can do now, and where it is heading, will allow you to have a realistic view of what might soon be delegated to an LLM.
2.What impossible thing can you do now? The flip side of the first question is that you now can do things that were impossible before. What does having an infinite number of interns for every employee get you? How does giving everyone a data analyst, marketer, and advisor change what is possible? You can look at some of the GPTs my students created as inspiration.
3.What can you move to a wider market or democratize? Prior to AI, companies were often advised to put their effort into servicing their most profitable customers, but AI has greatly changed the equation. Services and approaches that were once expensive to customize have become cheap. Prior to AI, strategy consulting firms would only work for giant clients for large fees, but now they may be able to offer effective advising to a much wider range of businesses at lower costs. Custom tutoring and mentoring, once available only to the rich, may be widely democratized.
4.What can you move upmarket or personalize? At the same time, your organization’s capabilities have increased. If you were once a small marketing firm, you can use AI to punch above your weight and offer services to elite clients that were once only available from much larger firms. With giant context windows and fast answers, every customer may be able to have a personal AI agent who knows their preferences and previous interactions with the company and communicates with them according to their preferences. Figure out the most exciting thing you can do, and see if you can make it happen.
Misguided companies will see any increase in performance from AI as an excuse to lay off staff, keeping their output the same. More forward-thinking firms will take advantage of these new capabilities to both improve the lives of their employees and expand their own capabilities. This is an area where leaders have agency over the future of AI and work. A lot depends on getting it right, and fast, because it is possible we are just getting started.
https://X.com/clairevo/status/1814747787856388435
https://www.mindstone.com/programs/ai-competency
https://www.aitra.com/contact-us
@levie
AI is going to cause us to move to higher levels of abstraction of how we work. Each level of abstraction provides more leverage than the prior level, so each bit of input leads to vastly higher output.This has happened all throughout history when there’s major technological progress, from the Industrial Revolution with mechanical automation and in the Information Age with digital automation. The work that we do today looks far different from 100 or 50 years ago respectively.
The same will be true again with AI. What we perceive is “work” today will continue to be redefined. When you can merely think of an idea to prototype and AI can generate the code, the timelines on building software suddenly alter. When you can instantly research a topic and understand it deeply without the hundred hours going down the wrong threads, you’ll move to the next task much quicker.
This will naturally change what we spend our time doing each day in almost every field. Building software will be as much about reviewing code and considering the right prompts as it is writing the code. Delivering a healthcare outcome will mean having access to every bit of research at your fingertips instantly, augmenting anything you already know. Every domain will experience a similar impact.
Skills will matter just as much as ever, but they will look different, just as skills have changed during every other technological revolution. And more people can get started in a field they’re interested in, while the experts in the field can get even more done than they could’ve before.
In just a few years, we will look back on how we used to work and be utterly surprised how long everything took to do. It will seem implausible that you had to literally do everything yourself on a computer, the thing that was invented to help automate work.
How I use LLMs
Marko Papic, the author of Geopolitical Alpha: An Investment Framework for Predicting the Future, is renowned for his “constraints framework.” This approach focuses on the economic, political, and geopolitical limitations that shape leaders’ decisions—often more decisively than personal preferences or ideologies. Below is a concise summary of his core ideas, followed by recent tweets and developments around the Canada–U.S. tariff conflict. I .highly recommend Marko Papic for interpreting geopolitics.
January 29:
January 31 – from @Geo_papic

February 1:
February 2:

Source: @SpecialSitsNews
@PeterBerezinBCA “Goldman this morning: “While the outlook is unclear, we think the Canada- and Mexico-focused tariffs are likely to be short-lived.”The problem with this view is that Trump won’t change course unless the stock market sells off bigly, but the stock market won’t sell off bigly if investors continue to think that the tariffs will be lifted soon.”
February 3:
@DeItaone “SENIOR CANADA GOV’T OFFICIAL TELLS NEW YORK TIMES THAT OTTAWA IS NOT OPTIMISTIC A REAL OFF-RAMP FROM TARIFFS EXISTS FOR CANADA THE WAY IT MATERIALIZED FOR MEXICO”
@LDrogen Trudeau’s task today is to come up with something completely performative to hand Trump because there doesn’t exist anything within the reasonable universe that isn’t performative he can actually hand him
@Geo_papic “All right, I have re-run the numbers on my sophisticated constraint-based trade war model. Here are the results (color coordinated!).”

February 3 – from @JustinTrudeau
@JustinTrudeau “I just had a good call with President Trump. Canada is implementing our $1.3 billion border plan—reinforcing the border with new choppers, technology and personnel, enhanced coordination with our American partners, and increased resources to stop the flow of fentanyl. Nearly 10,000 frontline personnel are and will be working on protecting the border.
In addition, Canada is making new commitments to appoint a Fentanyl Czar, list cartels as terrorists, ensure 24/7 eyes on the border, launch a Canada–U.S. Joint Strike Force to combat organized crime, fentanyl, and money laundering. I have also signed a new intelligence directive on organized crime and fentanyl, backed by $200 million.
Proposed tariffs will be paused for at least 30 days while we work together.”
This development illustrates ‘constraints over preferences’ on both sides. Canada’s political capital and economic interests propel efforts to avoid a significant trade escalation (at least it did at the last minute), while the U.S. has constraints on the potential losses from a trade war, making a face-saving agreement mutually advantageous. We shall see what happens when it comes to NATO/military spend, defense of the arctic, however,…
By zeroing in on the material, political, and economic constraints that decision-makers face, Papic’s method helps observers anticipate sudden shifts—such as an unexpected tariff pause or border-control measure. These insights often reveal that market-moving developments are less about leaders’ ideologies and more about the hard realities they cannot ignore.
The concessions by Trudeau may help towards solving another problem…there is ongoing commentary from figures like Sam Cooper, Stephen Punwasi, and Marc Cohodes, who raise questions about illicit financial flows and potential ties to organized crime, issues that might not have been adequately addressed up until now. Its a pity it took stupid tariff threats for this to materialize

Odds & Ends – An interesting perspective on trade:
Hudson Bay Capital: “The root of the economic imbalances lies in persistent dollar overvaluation that prevents the balancing of international trade, and this overvaluation is driven by inelastic demand for reserve assets.” “As global GDP grows, it becomes increasingly burdensome for the United States to finance the provision of reserve assets and the defense umbrella, as the manufacturing and tradeable sectors bear the brunt of the costs.”
“The emergence of a world where human intelligence is no longer a constraint on economic, social, and scientific endeavors would rapidly transform production and innovation. Cognitive hyper abundance would erase many traditional bottlenecks in R&D, enabling near-instantaneous breakthroughs in scientific fields ranging from biotechnology to clean energy. Markets would recalibrate as the marginal cost of knowledge-based products and services approached zero, dissolving old competitive barriers and creating wealth at an unprecedented rate. Economic sectors that once relied on specialized expertise would expand or shift toward tasks requiring creativity and empathy, while newly automated cognitive tasks would release immense human capacity to experiment with novel forms of entrepreneurship, research, and personal development.
Socially, the dissolution of intellectual barriers would trigger mass realignments in education, cultural expression, and governance. Education could become a process of creative exploration rather than rote instruction, with learners guided by systems capable of personalizing lessons and instantly correcting misunderstandings. The resulting democratization of advanced skills might neutralize inequality in knowledge access, though new challenges would arise around how societies regulate such transformative power. Old forms of prestige built upon scarcity of expertise could recede, and new forms of social distinction might develop around originality, emotional intelligence, and moral leadership.
In addition, political structures would likely adapt to manage the turbocharged pace of discovery. Governments might struggle to keep up with rapidly evolving norms and industries, forcing them to reimagine regulatory frameworks and possibly even the meaning of representative decision-making. The potential to solve existential challenges, including resource scarcity and environmental degradation, would be magnified by the proliferation of supercharged problem-solving tools. However, there could also be acute risks if the disparity in access and control of cognitive abundance were to concentrate power in the hands of a small elite or specialized organizations. These first-order consequences illustrate how solving ASI, defined here as removing the constraint of human intelligence, would catalyze profound shifts in virtually every dimension of human life.“