Sexual Health Rights - A Global Challenge

: diguclio; October 29th, 2011

Ever wonder what Sexology experts/sexual online pharmacy practitioners/educators talk about when they get together: Have a look at this - the World Association of Sexologists XIXth World of Sexual HealthCongress .

Here is the intoductory blurb:

"The conference theme, Sexual Health & Rights: A Global Challenge, reflects the 8 priorities of the WAS Declaration for the Millennium and echoes the urgent need for action to ensure sexual health and rights for all. The WAS Congress is held every two years, and brings together the outstanding clinicians, researchers, educators, activists and policy makers from around the globe to share knowledge on the diverse and often controversial issues of contemporary sexual health. Sweden has always played a pioneering role in promoting sexual education, health and equality. Furthermore, a grant from the Swedish Government will enable participants to attend from many developing countries where economic conditions prevent them from participating in this enriching global meeting".

Causes of Erectile dysfunction - Neurological problems

: diguclio; October 29th, 2011

Damage to any of the nerves that produce sensation or relay messages to arteries in the penis can also cause impotence. Diabetes is the most common cause of this kind of nerve damage. But degenerative diseases of the nervous system (such as multiple sclerosis or Parkinson's disease) and substance abuse can also harm the nerves involved in erections.
Likewise, erectile online pharmacy viagra can result from a spinal cord injury or as a side effect of various kinds of surgery. Because the nerve pathways to the penis travel near the prostate, bladder, and rectum, removing any of these organs to treat cancer can sever some of these nerves, leading to problems. In addition, vitamin B12 deficiency, which is a cause of anemia, can damage the spinal cord, causing neurological problems throughout the body.

Navitoclax, a targeted high-affinity inhibitor of BCL-2,

: diguclio; May 24th, 2011

The Lancet Oncology, Early Online Publication, 19 November 2010

Navitoclax, a targeted high-affinity cheap viagra of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

Original Text

Prof Wyndham H Wilson MD a Corresponding Author

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</img>, Prof Owen A O'Connor MD b, Prof Myron S Czuczman MD c, Ann S LaCasce MD d, John F Gerecitano MD e, Prof John P Leonard MD f, Anil Tulpule MD g, Kieron Dunleavy MD a, Hao Xiong PhD h, Yi-Lin Chiu PhD h, Yue Cui PhD h, Todd Busman MS h, Steven W Elmore PhD h, Saul H Rosenberg PhD h, Andrew P Krivoshik MD h, Sari H Enschede MD h, Rod A Humerickhouse MD h

Summary

Background

Proteins of the BCL-2 family regulate clonal selection and survival of lymphocytes, and are frequently overexpressed in lymphomas. Navitoclax is a targeted high-affinity small molecule that inhibits the anti-apoptotic activity of BCL-2 and BCL-XL. We aimed to assess the safety and antitumour activity of navitoclax in patients with lymphoid tumours, and establish the drug's pharmacokinetic and pharmacodynamic profiles.

Methods

In this phase 1 dose-escalation study, patients (aged ≥18 years) with relapsed or refractory lymphoid malignancies were enrolled and treated at seven sites in the USA between November, 2006, and November, 2009. A modified Fibonacci 3+3 design was used to assign patients to receive oral navitoclax once daily by one of two dosing schedules: intermittently for the first 14 days of a 21-day cycle (14/21) at doses of 10, 20, 40, 80, 110, 160, 225, 315, or 440 mg/day; or continuously for 21 days of a 21-day cycle (21/21) at doses of 200, 275, 325, or 425 mg/day. Study endpoints were safety, maximum tolerated dose, pharmacokinetic profile, pharmacodynamic effects on platelets and T cells, and antitumour activity. This trial is registered with ClinicalTrials.gov, number NCT00406809.

Findings

55 patients were enrolled (median age 59 years, IQR 51—67), 38 to receive the 14/21 dosing schedule, and 17 to receive the 21/21 dosing schedule. Common toxic effects included grade 1 or 2 anaemia (41 patients), infection (39), diarrhoea (31), nausea (29), and fatigue (21); and grade 3 or 4 thrombocytopenia (29), lymphocytopenia (18), and neutropenia (18). On the intermittent 14/21 schedule, dose-limiting toxic effects were hospital admissions for bronchitis (one) and pleural effusion (one), grade 3 increase in aminotransferases (one), grade 4 thrombocytopenia (one), and grade 3 cardiac arrhythmia (one). To reduce platelet nadir associated with intermittent 14/21 dosing, we assessed a 150 mg/day lead-in dose followed by a continuous 21/21 dosing schedule. On the 21/21 dosing schedule, two patients did not complete the first cycle and were excluded from assessment of dose-limiting toxic effects; dose-limiting toxic effects were grade 4 thrombocytopenia (one), grade 3 increase in aminotransferases (one), and grade 3 gastrointestinal bleeding (one). Navitoclax showed a pharmacodynamic effect on circulating platelets and T cells. Clinical responses occurred across the range of doses and in several tumour types. Ten of 46 patients with assessable disease had a partial response, and these responders had median progression-free survival of 455 days (IQR 40—218).

Interpretation

Navitoclax has a novel mechanism of peripheral thrombocytopenia and T-cell lymphopenia, attributable to high-affinity inhibition of BCL-XL and BCL-2, respectively. On the basis of these findings, a 150 mg 7-day lead-in dose followed by a 325 mg dose administered on a continuous 21/21 dosing schedule was selected for phase 2 study.

Funding

Abbott Laboratories, Genentech, and National Cancer Institute, National Institutes of Health.

Reproductive Health basics

: diguclio; May 17th, 2011

<td valign="top" readability="17"> home > reproductive health > reproductive cheap cialis basics

Reproductive health is a term that refers to the state of physical, mental, and social well-being of the reproductive system. In fact, good reproductive health means that a person is able to have a satisfying and safe sex life and that they are able to reproduce whenever they decide to do so.

Everyone should know about all of the safe and acceptable ways to plan a family and should know how to partake in adequate health-care services for pregnancy and for childbirth as well.

Reproductive health actually includes a much wider area than just physical well-being. Topics of reproductive health include things like sexual and gender related issues as well. Lately, these ideas have begun to be researched more than ever before because of the new importance of stem cell research and cloning methods that are becoming popular in modern science.

Some recent studies have even begun to point out the inequalities that many people face with reproductive health services. These inequalities in terms of the services offered to many sections of the world population have been said top be a major contributor to maternal morbidity and mortality in third world countries and elsewhere. There is definitely a growing need for more research into the inequalities of access to reproductive health services all over the world.

Many modern journals today are inviting research and studies into all areas of reproductive health. These areas include clinical practices, social and gender issues, sexual health, country and population specific issues and the overall assessment of access to reproductive health services.

It is of the utmost importance in today's growing technological age that there be a greater information dissemination, education and training about reproductive health if there is going to be an end to many of the common diseases that afflict humanity.

The challenge of the reproductive health field is for doctors and health practitioners to try and more thoroughly evaluate the emerging issues in reproductive health and make the services that have been developed in recent years more available to the less fortunate populations of the world.

With a better attention to the changing needs of reproductive health services, the population will likely benefit tremendously in the years to come.

More reproductive and sexual health information can be found at:

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Source: http://www.fitgroove.com/reproductive-health/reproductive-health-basics.asp

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: diguclio; May 3rd, 2011

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