Polycystic ovary syndrome affects over 10% of all females and is now thought of as much more wide-ranging metabolic disorder than ‘just’ a disease of the female reproductive system. CLI chatted to James Hawley (Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK and Laboratory of Medical Science, Medical Research Council, London, UK) to find […]
Nurgül Vatansever, Vice President & General Manager for EMEA (Europe, Middle East and Africa) at Beckman Coulter Diagnostics, brings more than 30 years of global healthcare leadership to her role. In this interview, she shares insights on the newly unified EMEA region in Beckman Coulter Diagnostics, the evolving diagnostics landscape, the importance of innovation, and […]
Lyme disease can be treated simply and effectively if caught early. However, significant challenges are associated with current tests. CLI chatted to Prof. Monica Embers (Tulane National Biomedical Research Center, Tulane University, New Orleans, LA, USA) to discover more about her single-tier test process that allows effective diagnosis at early stages of the disease.
Diagnosis of central nervous system vasculitis caused by varicella zoster virus (VZV) infection requires detection of intrathecally synthesized anti-VZV antibodies. One way of doing this is to test paired serum and cerebrospinal fluid samples and to calculate the antibody index using the Reiber formula. This method is not commonly used in the USA but can […]
Challenges and applications Measuring concentrations of steroid hormones – specifically androgens and estrogens – is challenging because they are present at very low concentrations and are structurally very similar. CLI chatted to James Hawley to find out more about these difficulties and how the assays are beginning to be used to measure testosterone levels in […]
Background Lenses and microscopes The use of microscopy has been pivotal to the diagnosis of disease for hundreds of years. The earliest evidence for the use of magnification dates back to the 5th century BC and the use of simple microscopes and lenses in spectacles in the 13th century AD. Compound microscopes appeared in Europe […]
The global prevalence of celiac disease is around 1%, although it is likely that many people remain undiagnosed. Historically, diagnosis was usually made in younger children, but the condition can develop at any age and the incidence is increasing in adults. Traditionally, a biopsy has been required to confirm diagnosis, but increased endoscopy waiting times […]
Laminin β4 (lamβ4) has been identified as a novel target antigen in anti-p200 pemphigoid, a rare autoimmune disease manifesting with subepidermal blisters. Anti-lamβ4 antibodies bind to the region of the dermal–epidermal junction and demonstrate pathogenic effects. A recombinant-cell indirect immunofluorescence assay has been developed for specific detection of anti-lamβ4 antibodies.
Volatile organic compounds (VOCs) are released from our bodies in our breath, sweat, blood and urine as a result of metabolic activity and so provide a window on our metabolic and physiological status. These VOCs change in response to disease, providing the potential for disease-specific VOCs in the breath to be used as non-invasive biomarkers […]
FK506 (tacrolimus) binding protein 12 (FKBP12) is involved in fundamental cellular processes as well as immunosuppression, neurodegenerative diseases and cancer. Hence, the ability to quickly and easily determine its levels is desirable. CLI caught up with Dr Pitruzzella, Dr Caminati and Prof. Cennamo to find out more about the point-of-care test that they have developed […]
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