Imagine Epinephrine
Delivered Differently
Get the latest updates on neffy® (epinephrine nasal spray )
Get the latest updates on neffy® (epinephrine nasal spray )
Get the latest updates on neffy(epinephrine nasal spray )
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THE FIRST & ONLY
FDA-APPROVED NEEDLE-FREE
EPINEPHRINE PRODUCT
Epinephrine is the first-line treatment to reverse the symptoms of anaphylaxis and the only medication proven to stop a potentially life-threatening allergic reaction.
neffy® is a nasal spray used for emergency treatment of allergic reactions including anaphylaxis, in adults and children aged who weigh 33 lbs or greater.
neffy® is designed to deliver epinephrine levels within range of injectable products and has demonstrated rapid onset and short time to resolution of symptoms in patients with anaphylaxis.
THE FIRST & ONLY
FDA-APPROVED NEEDLE-FREE
EPINEPHRINE PRODUCT
Epinephrine is the first-line treatment to reverse the symptoms of anaphylaxis and the only medication proven to stop a potentially life-threatening allergic reaction.
neffy® is a nasal spray used for emergency treatment of allergic reactions including anaphylaxis, in adults and children who weigh 33 lbs or greater.
neffy® is designed to deliver epinephrine levels within range of injectable products and has demonstrated rapid onset and short time to resolution of symptoms in patients with anaphylaxis.
THE FIRST & ONLY
FDA-APPROVED NEEDLE-FREE
EPINEPHRINE PRODUCT
Epinephrine is the first-line treatment to reverse the symptoms of anaphylaxis and the only medication proven to stop a potentially life-threatening allergic reaction.
neffy® is a nasal spray used for emergency treatment of allergic reactions including anaphylaxis, in adults and children who weigh 33 lbs or greater.
neffy® is designed to deliver epinephrine levels within range of injectable products and has demonstrated rapid onset and short time to resolution of symptoms in patients with anaphylaxis.
SERIOUS ALLERGIC REACTIONS
NEED IMMEDIATE ATTENTION
Prompt treatment with epinephrine at the first sign of symptoms is critical to stop disease progression and could reduce ER visits, hospital admissions and lost time at school or work. The lack or delay of treatment is associated with poor clinical outcomes, including comorbidities and fatalities.
neffy is aligned with what healthcare providers, patients and parents want – a treatment that offers peace of mind and confidence to immediately administer epinephrine upon onset of symptoms. With its small size, patients and caregivers indicate they will more likely carry 2 neffy devices and administer faster upon recognizing symptoms compared with current needle-injector products. This is critically important when symptoms are unpredictable and can initially present as mild in nature.
SEVERE ALLERGIC REACTIONS
NEED IMMEDIATE ATTENTION
Prompt treatment with epinephrine at the first sign of symptoms is critical to stop disease progression and could reduce ER visits, hospital admissions and lost time at school or work. The lack or delay of treatment is associated with poor clinical outcomes, including comorbidities and fatalities.
neffy is aligned with what healthcare providers, patients and parents want – a treatment that offers peace of mind and confidence to immediately administer epinephrine upon onset of symptoms. With its small size, patients and caregivers indicate they will more likely carry 2 neffy devices and administer faster upon recognizing symptoms compared with current needle-injector products. This is critically important when symptoms are unpredictable and can initially present as mild in nature.
neffy COMBINES THREE WELL-ESTABLISHED,
FDA APPROVED COMPONENTS:
Epinephrine
Device
Intravail® (dodecyl-maltoside)
THE GAP IN EDUCATION AND AWARENESS
Expert allergists agree that there’s a significant gap in both professional and patient education regarding the identification of risks and the proper use of epinephrine. Understanding these statistics underscores the need for improved education and resources to ensure timely and proper treatment of severe allergic reactions.
- Population Affected: Approximately 40 million people in the U.S. suffer from Type I severe allergic reactions, primarily triggered by food, venom, or insect stings.
- Under Physician Care: Only about half of these individuals (~20 million) are under a physician’s care.
- Epinephrine Prescriptions: Merely 3 million have a current prescription for epinephrine.
- Proper Usage: Alarmingly, 80-90% of those with prescriptions do not carry or administer epinephrine as indicated in a timely manner.
INDICATION AND IMPORTANT SAFETY INFORMATION
What is neffy?
neffy is a nasal spray used for emergency treatment of allergic reactions including anaphylaxis, in adults and children who weigh 33 lbs or greater.
What is the most important information that I should know about neffy?
neffy contains epinephrine, a medicine used to treat allergic emergencies (anaphylaxis). Anaphylaxis can be life-threatening, can happen in minutes, and can be caused by stinging and biting insects, allergy injections, foods, medicines, exercise, or other unknown causes.
Always carry two neffy nasal sprays with you because you may not know when anaphylaxis may happen and because you may need a second dose of neffy if symptoms continue or come back. Each neffy contains a single dose of epinephrine.
neffy is for use in the nose only.
Use neffy right away, as soon as you notice symptoms of an allergic reaction. If symptoms continue or get worse after the first dose of neffy, a second dose is needed. If needed, administer a second dose using a new neffy in the same nostril starting 5 minutes after the first dose. Get emergency medical help for further treatment of the allergic emergency (anaphylaxis), if needed after using neffy.
Tell your healthcare provider if you have underlying structural or anatomical nasal conditions, all the medicines you take, and about all your medical conditions, especially if you have heart problems, kidney problems, low potassium in your blood, Parkinson’s disease, thyroid problems, high blood pressure, diabetes, are pregnant or plan to become pregnant, or plan to breastfeed.
Tell your healthcare provider if you take or use other nasal sprays or water pills (diuretics) or if you take medicines to treat depression, abnormal heart beats, Parkinson’s disease, heart disease, thyroid disease, medicines used in labor, and medicines to treat allergies. neffy and other medications may affect each other, causing side effects. neffy may affect the way other medicines work, and other medicines may affect how neffy works.
What are the side effects of neffy?
neffy may cause serious side effects. If you have certain medical conditions or take certain medicines, your condition may get worse, or you may have more or longer lasting side effects when you use neffy.
Common side effects of neffy include: nasal discomfort, headache, throat irritation, chest and nasal congestion, feeling overly excited, nervous or anxious, nose bleed, nose pain, sneezing, runny nose, dry nose or throat, tingling sensation, including in the nose, feeling tired, dizziness, nausea, and vomiting.
Tell your healthcare provider if you have any side effects that bother you or that do not go away after using neffy.
These are not all of the possible side effects of neffy. Call your healthcare provider for medical advice about side effects. To report side effects, contact ARS Pharmaceuticals Operations, Inc. at 1-877-MY-NEFFY (877-696-3339) or the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Please see the full Prescribing Information and Patient Information for neffy.
INDICATION AND IMPORTANT SAFETY INFORMATION
What is neffy?
neffy is a nasal spray used for emergency treatment of allergic reactions including anaphylaxis, in adults and children aged 4 years and older who weight 33 lbs or greater.
What is the most important information that I should know about neffy?
neffy contains epinephrine, a medicine used to treat allergic emergencies (anaphylaxis). Anaphylaxis can be life-threatening, can happen in minutes, and can be caused by stinging and biting insects, allergy injections, foods, medicines, exercise, or other unknown causes.
Always carry two neffy nasal sprays with you because you may not know when anaphylaxis may happen and because you may need a second dose of neffy if symptoms continue or come back. Each neffy contains a single dose of epinephrine.
neffy is for use in the nose only.
Use neffy right away, as soon as you notice symptoms of an allergic reaction. If symptoms continue or get worse after the first dose of neffy, a second dose is needed. If needed, administer a second dose using a new neffy in the same nostril starting 5 minutes after the first dose. Get emergency medical help for further treatment of the allergic emergency (anaphylaxis), if needed after using neffy.
Tell your healthcare provider if you have underlying structural or anatomical nasal conditions, all the medicines you take, and about all your medical conditions, especially if you have heart problems, kidney problems, low potassium in your blood, Parkinson’s disease, thyroid problems, high blood pressure, diabetes, are pregnant or plan to become pregnant, or plan to breastfeed.
Tell your healthcare provider if you take or use other nasal sprays or water pills (diuretics) or if you take medicines to treat depression, abnormal heart beats, Parkinson’s disease, heart disease, thyroid disease, medicines used in labor, and medicines to treat allergies. neffy and other medications may affect each other, causing side effects. neffy may affect the way other medicines work, and other medicines may affect how neffy works.
What are the side effects of neffy?
neffy may cause serious side effects. If you have certain medical conditions or take certain medicines, your condition may get worse, or you may have more or longer lasting side effects when you use neffy.
Common side effects of neffy include: nasal discomfort, headache, throat irritation, chest and nasal congestion, feeling overly excited, nervous or anxious, nose bleed, nose pain, sneezing, runny nose, dry nose or throat, tingling sensation, including in the nose, feeling tired, dizziness, nausea, and vomiting.
Tell your healthcare provider if you have any side effects that bother you or that do not go away after using neffy.
These are not all of the possible side effects of neffy. Call your healthcare provider for medical advice about side effects. To report side effects, contact ARS Pharmaceuticals Operations, Inc. at 1-877-MY-NEFFY (877-696-3339) or the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Please see the full Prescribing Information and Patient Information for neffy.
- References:
- Commins, Scott P. Outpatient Emergencies: Anaphylaxis. Med Clin North Am. 2017; 101(3): 521-536
- Fleming et al. Early Treatment of Food-Induced Anaphylaxis with Epinephrine Is Associated with a Lower Risk of Hospitalization. J Allergy Clin Immunol Pract. 2015; 07.004
- Lee J, Rodio B, Lavelle J, et al. Improving Anaphylaxis Care: The Impact of a Clinical Pathway. Pediatrics. 2018;141(5):e20171616
- ARS Pharmaceuticals Operations, Inc. Data on File
- Golden et al. Anaphylaxis: A 2023 Practice Parameter Update. Joint Task Force on Practice Parameters. 2023
- Ring et al.History of Allergy. 2014; 54-61
- Rabinowicz et al. Improvement of Intranasal Drug Delivery with Intravail® Alkylsaccharide Excipient as a Mucosal Absorption Enhancer Aiding in the • Treatment of Conditions of the Central Nervous System. Drugs in R&D. 2021; 21:361–369
- Prince et al. Underuse of epinephrine for the treatment of anaphylaxis: missed opportunities. Journal of Asthma and Allergy. 2018; 11 143–151
- Warren et al. Epinephrine auto-injector carriage and use practices among US children, adolescents and adults. Ann Allergy Asthma Immunol. 2018; 121(4): 479-489e2
WOULD YOU LIKE MORE INFORMATION?
Contact us if you have questions about ARS Pharma or our product or products in development.