TRAINING

Postdoctoral Training Program in Aging Biology

A central part of the Aging Institute (AI) mission is to promote innovative research in aging and a rich environment for training of new generation of investigators in the aging field.  The partnership and exchange between University of Pittsburgh and UPMC allows basic and translational research with the objective to understand the connection between aging and chronic diseases and improve the quality of life of the elderly population. The research partners include:

The investigators of the Institute have experience and enthusiasm for training postdoctoral fellows and junior faculties.  Beyond individualized mentorship by top-notch basic and translational researchers, the institute offers mentorship in career development grant writing, presentation skills and provides opportunities for collaboration and networking with researcher within and outside the University.  The following programs are dedicated to supporting postdoctoral training within the Aging Institute:

Research Seminar Series – This monthly conference will have the mission to educate the scientific community at the University of Pittsburgh about the advancements in the aging biology field. Speakers will come not only from the AI and the research partners at the University of Pittsburgh but from across the nation and from overseas. All postodocs and junior faculties are required to attend. A dedicated session of questions and answers from postdocs is organized with speakers.

Networking Gathering – The AI sponsors a monthly series of informal discussions to stimulate collaborative research between faculties of the AI and the research partners. Presentations will be followed by a gathering to socialize and network. All postdocs are highly encouraged to attend this event to allow informal interaction with faculties and familiarize postdocs with the non-scientific skills required to pursue and succeed in an academic career.

AI Research in Progress – All postdocs and junior faculties are required to attend this monthly meeting and present their work at least once a year starting in their 2nd year. This seminar is a more informal venue in which junior investigators present their current research in order to gain scientific feedback as well as develop their oral presentation skills.

Journal Club – This journal club is a monthly activity and all postdocs and junior faculties are required to attend and to present at least once a year.  The goal of this meeting is to review current publications and to gain the skill of critically reviewing the literature.

Grant Writing Workshop – This workshop teaches the fundamentals of writing a grant application and guides trainees as they put together their first grant.  This workshop is limited to postdocs in their second year (or above) of training who have demonstrated significant scientific aptitude and have long term plans to stay in academia.

Program Leadership

Program Director:

Core Training Faculty: Toren Finkel, MD, PhD; Anne Newman, MD, MPH; Marta Bueno, PhD; Beibei Bill Chen, PhD;  Daniel Forman, MD; Aditi Gurkar, PhD; Gang Li, PhD; Jie Liu, PhD; Shihui Liu, MD, PhD; Yuan Liu, PhD;  Stacey Sukoff Rizzo, PhD; Shiori Sekine, PhD; Yusuke Sekine, PhD;  Matthew Steinhauser, MD; Jay Tan, PhD; Bokai Zhu, PhD.

CONTACT:

  • Research Seminar Series:  Bokai Zhu, PhD | bzhu@pitt.edu | 412-383-0447
  • Journal Club:  Bokai Zhu, PhD | bzhu@pitt.ed | 412-383-0447
  • Research In Progress: Xiaojun (Jay) Tan, PhD | jay.tan@pitt.edu | 412-383-4405

Trainee Spotlight

Heather Ballance, PhD

Dr. Heather Ballance works in the lab of Dr. Bokai Zhu. Her current projects include the 12-hour rhythms of RNA-binding proteins in nuclear speckles, endoplasmic reticulum (ER) protein content, and cell-to-cell communication through protein secretion. Dr. Ballance is supported by the T32 training program in the Division of Geriatrics, Department of Medicine.

Diana Davidek, MD

Dr. Davidek works in the lab of Dr. Aditi Gurkar and is studying how DNA damage promotes cellular senescence in cardiac disease and aging. In a collaboration with Dr. Cohen-Karni at Carnegie Mellon University, she hopes to re-create a 3D cardiac unit and understand human cardiac aging. Dr. Davidek is currently supported by the T32 training program in the Division of Geriatrics, Department of Medicine.

Kritika Chaddha, PhD

Kritika Chaddha, PhD, is a postdoctoral fellow under the mentorship of Dr. Aditi Gurkar. Her goal is to harness the power of organ-on-chip technology to deepen our understanding of cardiac aging, ultimately paving the way for innovative interventions and therapies to enhance heart health and quality of life.

Zhihao Sun, PhD

Zhihao Sun, PhD, has been a trainee under the supervision of Shihui Liu, MD, PhD, since 2021. His research focuses on identifying and characterizing novel factors involved in inflammasome-mediated pyroptosis — a form of programmed cell death triggered by inflammation.

Takeshi Murai, PhD

Takeshi Murai, PhD, is a trainee under the supervision of Stacey Sukoff Rizzo, PhD, and has worked in the Rizzo Lab since 2020. Prior to his work at the Aging Institute, Dr. Murai worked for more than 20 years in the pharmaceutical industry in Japan developing novel therapeutics to target the central nervous system.

Nandini Doshi

Nandini Doshi has been a trainee under the supervision of Matthew Steinhauser, MD, since May 2022. Doshi is a medical student in the Pitt’s Physician Scientist Training Program (PSTP). In the Steinhauser Lab, her research concentrates on elucidating novel immune signatures of resiliency in aging populations, with a focus on individuals undergoing cardiac surgery.

Shohini Ghosh-Choudhary

Shohini Ghosh-Choudhary is a medical student in Pitt’s physician-scientist Medical Scientist Training Program, which combines medical and research training to equip students to both treat patients and undertake cutting-edge research. She joined Dr. Toren Finkel’s lab in 2020 as his first PhD student, and her work in the lab focuses on CRISPR-based screening to identify targets for senolytic therapies.

Lauren Bailey

Lauren Bailey, PhD, is a postdoctoral scholar in the laboratory of Dr. Stacey Rizzo. She joined the Rizzo lab in 2023 as part of MARMO-AD, a consortium developing marmoset models of Alzheimer’s disease to identify early phenotypes and molecular mechanisms driving pathogenesis. Dr. Bailey’s research focuses on the transition from healthy aging to the earliest stages of Alzheimer’s disease and related neurodegeneration.

Travis Lear, PhD

Travis Lear, PhD, was awarded a National Institutes of Health F31 Individual Fellowship and is currently supported by the T32 training program in the Vascular Medicine Institute, Department of Medicine. In the past few months, he has been actively working on repurposing FDA-approved drugs against SARS-CoV-2.

Anna Kalmykov

Dr. Anna Kalmykov is a postdoctoral fellow working under the supervision of Dr. Andrey Parkhitko. Her research focuses on using high-throughput approaches to investigate the mechanisms underlying the beneficial effects of methionine restriction on aging and cancer, with particular emphasis on cancers driven by the loss of the RB1 tumor suppressor gene.

T32 Training Programs

Pitt Integrated Clinical and Geroscience Research Training Program T32

The goal of the Pitt Integrated Clinical and Geroscience Research Training Program T32 is to produce a new generation of investigators with a background in collaborative clinical, translational and the biology of aging methodology who have the enthusiastic commitment, knowledge and skills to succeed in a career in integrated clinical and geroscience research.  This two to three year postdoctoral training program is designed for MDs and PhDs.

Click here for an online version of the postdoctoral application form.

Applicant agrees to the following:

    • Commit to 2 to 3 years of training
    • Participate in the weekly Friday geriatric seminars (1.5 hours per week) and Pepper seminars (twice monthly)
    • Take at least one of the aging concentration courses in the CRTP, or if pursuing a basic science area, an alternative source of formal learning about aging research such as the month’s Biology of Aging seminar
    • Create and maintain a career portfolio with goals and timelines, self-assessment, and progress reports every 6 months
    • With the mentor, develop and submit to the T32 director a proposal for a specific project with publishable findings, preferably prior to starting the year but at minimum by month 3 of the training year

Application should include:

    • Completed Application Form
    • Statement of Career Goals (not to exceed 1 page)
    • Reference letters from applicant’s proposed mentor and one other reference
    • Curriculum vitaeor biographical sketch
    • Primary mentor’s NIH biographical sketch

 

Completed Applications may be e-mailed to:
greenspn@pitt.edu with cc to Janelle Christensen: jjc157@pitt.edu

Epidemiology of Aging T32 NIH Training Grant

PI: Anne Newman, MD

The NIH-funded T-32 program from the National Institute on Aging has provided support to trainees in the Epidemiology of Aging program for over 25 years, and was recently refunded to continue through 2021. The program provides support for 2 pre- and 2 post-doctoral trainees, with openings when slots become available. Training cycles begin in the fall term, to maintain alignment with course scheduling. Trainees are provided with 2-3 years of academic support and a stipend.

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