Bruce Booth (@LifeSciVC) / X

Bruce Booth

12.1K posts

Bruce Booth

@LifeSciVC

Early stage biotech VC. Recovering scientist. Opinions expressed are solely my own and do not express the views or opinions of Atlas Venture.

Cambridge, MA

Joined December 2010

Bruce Booth
@LifeSciVC
Sep 17, 2019
Only in Cambridge: I’m stuck in traffic on the exit from the Pike and a biotech CEO pulls up next to me, rolls window down and says “Hey Bruce, we’ve got great NHP efficacy data... can’t wait to show you”... Made my commute far less painful! This ecosystem never ceases to amaze
Bruce Booth
@LifeSciVC
Feb 4, 2022
Biotech is just so small. $FB lost $200B yesterday due to metaverse investing... which is more than the combined pre-money valuations of the 360+ biotech IPOs since 2015. Trying to make a virtual world vs trying to make real medicines. Both are challenging, it seems.
Bruce Booth
@LifeSciVC
May 6, 2021
Waiving IP has consequences... slippery slope... now they say “do insulin next”? Let’s do PD1s after that because cancer is a global crisis... Then let’s do Alzheimer’s.. Oh wait, we have no drugs for AD yet... and nor will we if there are no patents or reward for innovating
Bruce Booth
@LifeSciVC
Mar 16, 2021
Personal Reflection: Empathy In The Workplace Life isn't always easy, and many of us have a lot going on underneath the facade, but its the emotional connectedness with others that makes all the difference. To those that have been there for me, thx you
lifescivc.com
Personal Reflection: Empathy In The Workplace - LifeSciVC
Just before I chaired a Board meeting last year, I spent a frustratingly painful hour going through many of the uncomfortable details of my divorce process and a set of emotional custody issues with...
Bruce Booth
@LifeSciVC
Mar 15, 2025
One of the most compelling cold email VC pitches I've ever received... very hard to not feel a strong desire to invest in this startup and back this CEO... Can you imagine how fun Board meetings would be? Wow.
73K
Bruce Booth
@LifeSciVC
Jan 14, 2019
The Game Isn’t Worth The Candle: Reflections On The JPM Healthcare Conference. More concerned than ever about the value of the JPM week and what it says about our industry. lifescivc.com/2019/01/the-ga… #JPM19 #JPMHC19
lifescivc.com
The Game Isn’t Worth The Candle: Reflections On The JPM Healthcare Conference - LifeSciVC
Another year, another JPM week. With a weekend to recuperate and reflect, I come away more concerned than ever about JPM and our industry. For context, by JPM I don’t mean the actual J.P. Morgan...
Bruce Booth
@LifeSciVC
Mar 24, 2020
In mild COVID-19 patients, placebo was similarly effective to HCQ in viral clearance. Randomized open label clinical trial (NCT04261517): in 30 mild patients, 93% cleared virus w/in 7 days on placebo (vs 87% with HCQ). h/t Umer Raffat at EvercoreISI
Bruce Booth
@LifeSciVC
Apr 1, 2025
FDA turmoil is creating huge uncertainty for biotech... so much institutional knowledge is being lost... and upheaval is never good for productivity. One of the most challenging aspects of this uncertainty is it's not clear (at least to me) what the direction of travel will be
47K
Bruce Booth
@LifeSciVC
Nov 16, 2021
Atlas Venture 2021 Year In Review Here's our "state of the industry" talk (that we just shared with our LP's at our Annual Meeting) exploring the macro issues & broader sector, diving into the biotech VC ecosystem, and providing a brief update on Atlas.
Bruce Booth
@LifeSciVC
Oct 14, 2025
Twenty Years In Early Stage Biotech VC (Part 1) Here are some observations on the “Science” of startups from my vantage point as an early stage VC… · Science-first opportunism beats top-down strategy for deal selection · Don’t believe what you read in science papers at face
Bruce Booth
@LifeSciVC
Oct 13, 2025
Twenty years ago in mid-October 2005, I joined @atlasventure. Hard to believe - time flies. A big thank you to my partners JF Formela and Peter Barrett, who took a bet on me. Both have been great mentors, partners, and friends. Since 2005, I've worked with hundreds of
lifescivc.com
Twenty Years In Early Stage Biotech VC (Part 1): Science - LifeSciVC
In the blink of an eye, twenty years have passed: in mid-October 2005, I joined Atlas Venture as a principal on the global life science team. We closed Fund VII a few months after I joined; and,...
88K
Bruce Booth
@LifeSciVC
Jul 1, 2024
A Molecular Biologist’s Advice For Life. Having just turned 50, I’ve been reflecting on my first half-century… my passion for science as a lens for looking at the world has been a thread that has run throughout. Here are 12 pieces of advice for college & early career STEM
61K
Bruce Booth
@LifeSciVC
May 14, 2021
Surprising stat: >50% of biotech's that IPO'd between 2000-2013 have had at least one product approved. 8% of those IPOs actually got 2 products approved. (Thx to Josh Schimmer at Evercore ISI)
Bruce Booth
@LifeSciVC
Jan 14, 2025
What a journey for Intracellular Therapies Inc ($ITCI) - acquired yesterday at the ripe age of 23 yrs old. Series A of $2.9M in 2002. Moshe Alafi, called one of the founders of biotech (whose VC firm backed Cetus, Amgen, ABI, others) was the lead of the A-round. Over next
34K
Bruce Booth
@LifeSciVC
Nov 7, 2022
Here’s the Atlas Venture 2022 Year In Review. This year, given the 2+ year rollercoaster in the mkts, we start with a deep dive into both the public and private #biotech capital markets, then to the industry overall, closing with an update on ⁦Atlas