“Galina and I worked on several applied machine learning projects together, she is technically strong, goal-driven and super collaborative. She works well with people across team boundaries and in different disciplines: including engineers, product managers, data scientists and applied research scientists. While driving these machine learning projects, Galina also conducted extensive data analysis to gauge impact and recommend best solutions based on data. Galina is transparent and effective in her communications with the team, while also keeps stake holders updated on overall project status. She is able to convey both technical details and high-level pictures based on the target audience. Galina would be an asset to any team she joins! ”
About
• Extensive research…
Activity
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Following Thanksgiving, LinkedIn is running an amazing #DonateAwareness and #GivingTuesday campaign! I am happy to support Ukraine Defense Fund. I…
Following Thanksgiving, LinkedIn is running an amazing #DonateAwareness and #GivingTuesday campaign! I am happy to support Ukraine Defense Fund. I…
Liked by Galina Malovichko, PhD
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Hi Friends, Connections and LinkedIn Network, Happy, safe and healthy 2021! Natural Language Processing (NLP) is one of the fastest growing areas…
Hi Friends, Connections and LinkedIn Network, Happy, safe and healthy 2021! Natural Language Processing (NLP) is one of the fastest growing areas…
Shared by Galina Malovichko, PhD
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Lyft had to make a hard decision today to layoff some great employees from all roles including data scientists and science managers. DM me if you're…
Lyft had to make a hard decision today to layoff some great employees from all roles including data scientists and science managers. DM me if you're…
Liked by Galina Malovichko, PhD
Experience & Education
Licenses & Certifications
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Introduction to Recommender Systems
Coursera Verified Certificates
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Exploratory Data Analysis
Coursera Verified Certificates
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Getting and Cleaning Data
Coursera Verified Certificates
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Practical Machine Learning
Coursera Verified Certificates
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The Data Scientist’s Toolbox
Coursera Verified Certificates
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Publications
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Label-Free Real-Time Monitoring of Reactions Between Internalin A and Its Antibody by an Oblique-Incidence Reflectivity-Difference Method
ACS Omega
See publicationUsing a microarray-based assay, we studied how the substitution of amino acids in the immediate vicinity of the receptor-binding domain on a peptide affects its binding to a protein. Replicates of 802 linear peptides consisting of the variants of WTHPQFAT and LQWHPQAGK, GKFPIPLGKQSG, and NGQFQVWIPGAQK, different by one amino acid, were synthesized on a glass slide with a maskless photolithography. Using a microarray-compatible label-free optical sensor, we measured the binding curves of…
Using a microarray-based assay, we studied how the substitution of amino acids in the immediate vicinity of the receptor-binding domain on a peptide affects its binding to a protein. Replicates of 802 linear peptides consisting of the variants of WTHPQFAT and LQWHPQAGK, GKFPIPLGKQSG, and NGQFQVWIPGAQK, different by one amino acid, were synthesized on a glass slide with a maskless photolithography. Using a microarray-compatible label-free optical sensor, we measured the binding curves of streptavidin with the synthesized peptides and extracted the streptavidin–peptide affinity constants. We found that (a) the substitution of one residue in the HPQ motif reduces the affinity constant Ka from 10⁸ M–1 by at least 3–4 orders of magnitude, with an exception of HPM; (b) substitution of the immediate flanking residue on the Gln side also causes the affinity to decrease by up to 3–4 orders of magnitude, depending on the substituting residue and the second-neighboring flanking residue; (c) substitution of the flanking residues on the His side has no significant effect on the affinity, possibly due to the strong binding of streptavidin to HPQF and HPQAG motifs. We also found that some of amino acid residues located close to the C-terminus (and the solid surface) improve the yield of peptide synthesis on a glass surface and can be exploited in the fabrication of peptide microarrays.
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Single Amino Acid Substitution in the Vicinity of a Receptor-Binding Domain Changes Protein–Peptide Binding Affinity
ACS Omega
See publicationUsing a microarray-based assay, we studied how the substitution of amino acids in the immediate vicinity of the receptor-binding domain on a peptide affects its binding to a protein. Replicates of 802 linear peptides consisting of the variants of WTHPQFAT and LQWHPQAGK, GKFPIPLGKQSG, and NGQFQVWIPGAQK, different by one amino acid, were synthesized on a glass slide with a maskless photolithography. Using a microarray-compatible label-free optical sensor, we measured the binding curves of…
Using a microarray-based assay, we studied how the substitution of amino acids in the immediate vicinity of the receptor-binding domain on a peptide affects its binding to a protein. Replicates of 802 linear peptides consisting of the variants of WTHPQFAT and LQWHPQAGK, GKFPIPLGKQSG, and NGQFQVWIPGAQK, different by one amino acid, were synthesized on a glass slide with a maskless photolithography. Using a microarray-compatible label-free optical sensor, we measured the binding curves of streptavidin with the synthesized peptides and extracted the streptavidin–peptide affinity constants. We found that (a) the substitution of one residue in the HPQ motif reduces the affinity constant Ka from 10⁸ M–1 by at least 3–4 orders of magnitude, with an exception of HPM; (b) substitution of the immediate flanking residue on the Gln side also causes the affinity to decrease by up to 3–4 orders of magnitude, depending on the substituting residue and the second-neighboring flanking residue; (c) substitution of the flanking residues on the His side has no significant effect on the affinity, possibly due to the strong binding of streptavidin to HPQF and HPQAG motifs. We also found that some of amino acid residues located close to the C-terminus (and the solid surface) improve the yield of peptide synthesis on a glass surface and can be exploited in the fabrication of peptide microarrays.
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Zero Loop-Area Sagnac Interferometer at Oblique-Incidence for Detecting in-Plane Magneto-Optic Kerr Effect.
AIP Advances
See publicationWe describe a zero loop-area Sagnac interferometer at oblique incidence for detecting magneto-optic Kerr effect arising from in-plane magnetization in a sample. By exploiting properties of polarization states under relevant crystal symmetry transformation, we show that contributions from longitudinal and transverse Kerr effects can be separated. In addition we can select one optical arrangement out of four that detects the longitudinal effect with the highest signal-to-noise ratio. Compared to…
We describe a zero loop-area Sagnac interferometer at oblique incidence for detecting magneto-optic Kerr effect arising from in-plane magnetization in a sample. By exploiting properties of polarization states under relevant crystal symmetry transformation, we show that contributions from longitudinal and transverse Kerr effects can be separated. In addition we can select one optical arrangement out of four that detects the longitudinal effect with the highest signal-to-noise ratio. Compared to finite loop-area Sagnac interferometers operating at oblique incidence, the zero loop-area interferometer involves significantly fewer optical elements and is thus more stable against drifts in the optical system. For demonstration, we measured the in-plane magneto-optic Kerr effect from a 42-nm Ni film.
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High-Throughput Dose–Response Measurement Using a Label-Free Microarray-in-Microplate Assay Platform
Analytical Chenistry
Microarray-based binding assays facilitate the discovery of protein ligands from large collections of small molecules. Hundreds of ligands can be identified, yet only a small portion of them have interfering effects (competitive or noncompetitive) on a specific protein–receptor binding reaction. Further efficient screening of ligands for those with specific modifying effect is needed in order to take the full advantage of throughputs of microarray-based assays for drug discovery. We report a…
Microarray-based binding assays facilitate the discovery of protein ligands from large collections of small molecules. Hundreds of ligands can be identified, yet only a small portion of them have interfering effects (competitive or noncompetitive) on a specific protein–receptor binding reaction. Further efficient screening of ligands for those with specific modifying effect is needed in order to take the full advantage of throughputs of microarray-based assays for drug discovery. We report a label-free “microarray-in-microplate” assay platform for simultaneous acquisition of at least 32 dose–response curves in a single experiment, each curve having 12 concentration points. When combined with ligand discovery, this makes the microarray-based platform a true high-throughout means of finding inhibitors to specific protein–receptor reactions starting from a large collection of small-molecule libraries.
Other authors -
Projects
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Coupon Purchase Prediction
See projectUsed user and coupon features and past purchases data to predict what coupons should be promoted to which user.
Languages
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Russian
Native or bilingual proficiency
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English
Full professional proficiency
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German
Elementary proficiency
Recommendations received
4 people have recommended Galina
Join now to viewMore activity by Galina
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Finally, the third launch of our Open Machine Learning Course has finished! Two successful launches on Russian were followed by experimental English…
Finally, the third launch of our Open Machine Learning Course has finished! Two successful launches on Russian were followed by experimental English…
Liked by Galina Malovichko, PhD
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Won first place on the AI hackathon at Moscow
Won first place on the AI hackathon at Moscow
Liked by Galina Malovichko, PhD
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Our team "DecisionGuys" finished 10th in the Kaggle Toxic Comments Classification Challenge, with gold medals!!! This result makes me a Kaggle…
Our team "DecisionGuys" finished 10th in the Kaggle Toxic Comments Classification Challenge, with gold medals!!! This result makes me a Kaggle…
Liked by Galina Malovichko, PhD
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5 февраля стартует открытый курс OpenDataScience по машинному обучению
5 февраля стартует открытый курс OpenDataScience по машинному обучению
Liked by Galina Malovichko, PhD
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Me and colleagues just released a paper "Pediatric Bone Age Assessment Using Deep Convolutional Neural Networks" This is a fusion of our approaches…
Me and colleagues just released a paper "Pediatric Bone Age Assessment Using Deep Convolutional Neural Networks" This is a fusion of our approaches…
Liked by Galina Malovichko, PhD
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Breathtaking and Breaking news!! (short insight: Bitcoin is 100% legal now in Belarus and even tax exempt!) The President of Belarus just signed…
Breathtaking and Breaking news!! (short insight: Bitcoin is 100% legal now in Belarus and even tax exempt!) The President of Belarus just signed…
Liked by Galina Malovichko, PhD
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I got my first medal in the Kaggle! I'm amazed. I never thought that it possible without powerful devbox or without blending public kernels. Never…
I got my first medal in the Kaggle! I'm amazed. I never thought that it possible without powerful devbox or without blending public kernels. Never…
Liked by Galina Malovichko, PhD
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Congrats to our Data Scientists who rank the best at computer vision in this Carvana competition on Kaggle: #1 Artem Sanokaev, Alexander Buslaev…
Congrats to our Data Scientists who rank the best at computer vision in this Carvana competition on Kaggle: #1 Artem Sanokaev, Alexander Buslaev…
Liked by Galina Malovichko, PhD
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We won 1st place #TADHack in SaintPetesburg 2017 #TADHack2017
We won 1st place #TADHack in SaintPetesburg 2017 #TADHack2017
Liked by Galina Malovichko, PhD
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I'm very glad to become a Kaggle Master and be ranked Top 48 on Kaggle!
I'm very glad to become a Kaggle Master and be ranked Top 48 on Kaggle!
Liked by Galina Malovichko, PhD
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