Diffuse Bio reposted this
Excited to share a new major capability from Diffuse Bio: RamaX Opt, our ultra-fast affinity maturation and sequence optimization workflow. We demonstrate 4–50× affinity improvements across 4 starting CD3 binders, plus sequence liability removal — all in ~1 week. To our knowledge, this is the fastest affinity maturation method available, outperforming even the most advanced existing experimental and AI approaches. And this is just a limited first pass — single point mutations for some sequences and modest combinatorial diversity for others. RamaX can handle very large and diverse libraries, so there's plenty of room to push further. With DiffuseSandbox for design, RamaX for discovery, and now RamaX Opt for optimization, the full path from target to optimized lead candidate takes weeks, not months. The bigger picture for us at Diffuse Bio: the bottleneck in AI protein design isn't model architecture — it's data. Every affinity maturation campaign on RamaX produces thousands of sequence-affinity measurements that flow directly back into training our next generation of protein design models. Better data, better models, better designs — repeat. To learn more: - Read our blog post here: https://lnkd.in/gJNVPa6e - Read Section 5 in our updated technical report: https://lnkd.in/g6beH-pu Interested in partnering? Get started at ramax.diffuse.bio or reach out to discuss. We're also hiring computational and experimental scientists — if these problems excite you, come work with us!