Top 23 Python Agent Projects

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1. ragflow

   1 17 74,589 10.0 Python

   RAGFlow is a leading open-source Retrieval-Augmented Generation (RAG) engine that fuses cutting-edge RAG with Agent capabilities to create a superior context layer for LLMs

   

   Project mention: Ragflow | news.ycombinator.com | 2026-03-09

2. InfluxDB

   www.influxdata.com featured

   InfluxDB – Database Purpose-Built for High-Resolution Data. Turn time series data into real-time intelligence. Manage high-volume, high-velocity data without sacrificing performance.

   

3. OpenHands

   2 36 68,600 10.0 Python

   🙌 OpenHands: AI-Driven Development

   

   Project mention: Show HN: CodeRLM – Tree-sitter-backed code indexing for LLM agents | news.ycombinator.com | 2026-02-11

4. LlamaFactory

   3 8 68,077 9.6 Python

   Unified Efficient Fine-Tuning of 100+ LLMs & VLMs (ACL 2024)

   

   Project mention: Llama-Factory: Unified, Efficient Fine-Tuning for 100 Open LLMs | news.ycombinator.com | 2025-09-18

5. MetaGPT

   4 39 64,853 9.1 Python

   🌟 The Multi-Agent Framework: First AI Software Company, Towards Natural Language Programming

   

   Project mention: Backlog.md – CLI that auto-generates task files (took my Claude success to 95 %) | news.ycombinator.com | 2025-07-06

6. unsloth

   5 30 53,421 9.9 Python

   Fine-tuning & Reinforcement Learning for LLMs. 🦥 Train OpenAI gpt-oss, DeepSeek, Qwen, Llama, Gemma, TTS 2x faster with 70% less VRAM.

   

   Project mention: I Built an Automated SLM Fine-Tuning Engine with Python and Unsloth 🚀 | dev.to | 2026-01-19

   For the actual training, I rely on Unsloth. It makes fine-tuning 2x faster and uses 70% less memory.

7. mem0

   6 23 49,055 9.6 Python

   Universal memory layer for AI Agents

   

   Project mention: Your AI Agent's Memory Is Broken. Here Are 4 Architectures Racing to Fix It | dev.to | 2026-03-10

   How it works: Mem0 and Zep store memories as temporal knowledge graphs. Instead of embedding text chunks, they extract entities and relationships ("User → works at → Acme Corp", "User → prefers → TypeScript"), track how these relationships change over time, and traverse the graph to answer queries that require understanding connections.

8. ChatTTS

   7 4 38,908 6.2 Python

   A generative speech model for daily dialogue.

   

9. SaaSHub

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10. khoj

    8 51 33,177 9.7 Python

    Your AI second brain. Self-hostable. Get answers from the web or your docs. Build custom agents, schedule automations, do deep research. Turn any online or local LLM into your personal, autonomous AI (gpt, claude, gemini, llama, qwen, mistral). Get started - free.

    

11. Jobs_Applier_AI_Agent_AIHawk

    9 9 29,420 7.4 Python

    AIHawk aims to easy job hunt process by automating the job application process. Utilizing artificial intelligence, it enables users to apply for multiple jobs in a tailored way.

    

12. gpt-researcher

    10 8 25,628 9.4 Python

    An autonomous agent that conducts deep research on any data using any LLM providers

    

    Project mention: 1500 Lines of Markdown vs 15000 Lines of Python. | dev.to | 2025-12-31

    I spent a weekend studying GPT-Researcher, an open-source project with 24,000+ GitHub stars. It builds an autonomous research agent that generates comprehensive reports with citations. The architecture is elegant: multiple specialized agents coordinate through LangGraph, parallel execution speeds up research, and quality gates ensure reliable output.

13. deer-flow

    11 6 26,617 9.7 Python

    An open-source SuperAgent harness that researches, codes, and creates. With the help of sandboxes, memories, tools, skills and subagents, it handles different levels of tasks that could take minutes to hours.

    

    Project mention: Components structure in deerflow codebase - Part 1.1 | dev.to | 2026-03-05

    Inspired by BulletProof React, I applied its codebase architecture concepts to the bytedance/deerflow.

14. vanna

    12 24 22,874 8.9 Python

    🤖 Chat with your SQL database 📊. Accurate Text-to-SQL Generation via LLMs using Agentic Retrieval 🔄.

    

    Project mention: How to Use Vanna.ai to Query Your Database with Open-Source Language Models | dev.to | 2025-12-02

    Vanna.ai GitHub: https://github.com/vanna-ai/vanna

15. serena

    13 15 21,065 9.9 Python

    A powerful coding agent toolkit providing semantic retrieval and editing capabilities (MCP server & other integrations)

    

    Project mention: Show HN: CS – indexless code search that understands code, comments and strings | news.ycombinator.com | 2026-02-22

    Can you share how it compares to Serena? https://github.com/oraios/serena

16. AstrBot

    14 2 20,412 9.9 Python

    Agentic IM Chatbot infrastructure that integrates lots of IM platforms, LLMs, plugins and AI feature, and can be your openclaw alternative. ✨

    

    Project mention: AstrBot: Revolutionizing Chatbot Development with Ease and Flexibility | dev.to | 2025-03-26

    View the Project on GitHub

17. SWE-agent

    15 10 18,708 9.1 Python

    SWE-agent takes a GitHub issue and tries to automatically fix it, using your LM of choice. It can also be employed for offensive cybersecurity or competitive coding challenges. [NeurIPS 2024]

    

    Project mention: Boost Your Coding Agent and Understand Its Reasoning with 3 Simple Prompts | dev.to | 2025-06-20

    SWE-Agent

18. DeepResearch

    16 5 18,347 9.3 Python

    Tongyi Deep Research, the Leading Open-source Deep Research Agent

    

    Project mention: Tongyi DeepResearch – open-source 30B MoE Model that rivals OpenAI DeepResearch | news.ycombinator.com | 2025-11-02

19. agentscope

    17 4 17,561 9.5 Python

    Build and run agents you can see, understand and trust.

    

    Project mention: All Data and AI Weekly #207: 15 Sept 2025 | dev.to | 2025-09-15

    GitHub Link: https://github.com/agentscope-ai/agentscope Summary: Agentscope is an agent-oriented programming library that makes it easier to build LLM applications. It's designed to be "developer-centric" with features like asynchronous execution, parallel tool calls, and real-time steering. It offers a transparent approach where prompt engineering and API invocation are fully visible and controllable. Why it's important: Agentscope, along with its related libraries like agentscope-runtime and agentscope-studio, provides a comprehensive toolkit for not only developing but also deploying and visualizing agent-based applications.

20. camel

    18 18 16,190 9.9 Python

    🐫 CAMEL: The first and the best multi-agent framework. Finding the Scaling Law of Agents. https://www.camel-ai.org

    

    Project mention: Eigent: An open source Claude cowork alternative | news.ycombinator.com | 2026-01-14

    You can have a try; almost all sota models are supported all powered thanks to https://github.com/camel-ai/camel

21. agent-zero

    19 5 15,979 9.8 Python

    Agent Zero AI framework

    

    Project mention: OSS Alternative to Open WebUI – ChatGPT-Like UI, API and CLI | news.ycombinator.com | 2025-11-03

22. LangBot

    20 3 15,480 9.9 Python

    ChatGPT chat bot for Tencent QQ, based on mirai and OpenAI API.

    

    Project mention: Finally Got My Dify Agent Working in Discord, Telegram and Slack | dev.to | 2025-12-10

    LangBot is the most powerful open-source multi-platform chatbot framework available. It supports major Chinese IMs (QQ, WeChat, Feishu, DingTalk) and international platforms (Telegram, Discord, Slack, LINE). Its core strength is connecting AI backends to messaging apps.

23. agent-lightning

    21 3 15,369 9.5 Python

    The absolute trainer to light up AI agents.

    

    Project mention: Daily Artificial Intelligence Digest - Oct 26, 2025 | dev.to | 2025-10-25

    Microsoft's agent-lightning project offers a comprehensive toolkit aimed at accelerating the process of building, testing, and deploying AI Agents. This open-source initiative highlights the industry's commitment to enabling faster development and implementation of advanced AI capabilities, providing developers with robust resources to streamline AI agent creation.

24. memU

    22 9 12,642 9.5 Python

    Memory for 24/7 proactive agents like openclaw (moltbot, clawdbot).

    

    Project mention: Show HN: We built a cheaper, simpler 24/7 proactive agent than moltbot | news.ycombinator.com | 2026-01-28

    https://github.com/NevaMind-AI/memU

    Happy to hear thoughts from people building agents or infra in this space.

25. Memori

    23 9 12,295 9.6 Python

    SQL Native Memory Layer for LLMs, AI Agents & Multi-Agent Systems

    

    Project mention: Daily AI & Automation Tech News - November 20, 2025 | dev.to | 2025-11-19

    Link: https://github.com/GibsonAI/Memori

26. SaaSHub

    www.saashub.com featured

    SaaSHub - Software Alternatives and Reviews. SaaSHub helps you find the best software and product alternatives

    

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• A note from our sponsor - SaaSHub
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  SaaSHub helps you find the best software and product alternatives Learn more →

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