Our vision for the I.S.I. is to strengthen and expand its leading role in the development and application of I4.0 technologies, while actively supporting Europe’s twin green and digital transitions and advancing the principles of I5.0. The Institute contributes to shaping a new industrial paradigm that places human-centricity, sustainability, and resilience at its core, integrating human expertise with artificial intelligence and advanced digital and industrial technologies. I.S.I. aims to enhance efficiency and productivity, while addressing key European challenges related to climate neutrality, competitiveness, strategic autonomy, and long-term socio-economic growth within a rapidly evolving industrial and societal landscape.