Better Microbiome Thinking

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The Hidden Variables: Controls, Anchors, and Accountability in Microbiome Research
I was recently asked for my take on the “blue whale” in microbiome research: the lack of standardization that leads to non replication and even opposite…
 • William DePaolo PhD
Shiny Maps, Missing Keys: The Stool Metabolome “Diet Readout” Problem
Big cohorts, bigger claims, and the inconvenient parts of reproducibility
 • William DePaolo PhD
Better Microbiome Thinking's Microbiome Awards 2025
The gut space tried to grow up this year, got bullied by reality, then quietly started doing the homework anyway. Here’s the wins, fails and the stuff…
 • William DePaolo PhD
Stop Ranking Bugs. Start Proving Health.
The evidence checklist no gut health score wants you to see
 • William DePaolo PhD
THE SWEET STUFF
In our dietary habits, there exists a notable overconsumption of sugar within the populace.
 • William DePaolo PhD
B VITAMINS & YOUR GUT MICROBES
B vitamins constitute a crucial group of water-soluble organic compounds vital for various physiological functions across nearly all living organisms.
 • William DePaolo PhD
How stress impacts your Microbiome
In today’s fast-paced society, stress has become an unavoidable component of daily life.
 • William DePaolo PhD
A Field Out of Balance. Part 2.
How the microbiome “boom” locked in power instead of sharing it
 • William DePaolo PhD
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