Basil Rathbone Sherlock Holmes Nigel Bruce Dr. John H. Watson Alan Mowbray Major Duncan-Bleek Dennis Hoey Inspector Lestrade Renee Godfrey Vivian Vedder Frederick Worlock Prof. William Kilbane Mary Forbes Lady Margaret Carstairs Skelton Knaggs Sands - Moran's Accomplice Billy Bevan Conductor Taking Tickets Geoffrey Steele Roland Carstairs Janet Murdoch Mrs. Shallcross (uncredited) Gerald Hamer Alf Shallcross (uncredited) Leyland Hodgson Senior Conductor (uncredited) Harry Cording Mock the Undertaker (uncredited) Charles Knight Baggage Car Guard (uncredited) Boyd Davis "Inspector MacDonald" (uncredited) Bobby Wissler Mock Jr. (uncredited) Gilbert Allen Dining Car Steward (uncredited) C. Aubrey Smith Elderly gentleman on train station (uncredited) Roy William Neill Director Maury Gertsman Director Melville Shyer Director