{"id":177130,"date":"2022-02-04T13:23:16","date_gmt":"2022-02-04T18:23:16","guid":{"rendered":"http:\/\/velscope.com\/?p=177130"},"modified":"2022-02-04T13:23:16","modified_gmt":"2022-02-04T18:23:16","slug":"abnormal-pap","status":"publish","type":"post","link":"https:\/\/velscope.com\/abnormal-pap\/","title":{"rendered":"Impact of Prior HPV Infection or History of Abnormal Pap Smear and HPV"},"content":{"rendered":"
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The Impact Of A Prior HPV Infection Or A History Of Abnormal Pap Smear On The Humoral Immune Response To A Quadrivalent Human Papillomavirus (qHPV) Vaccination<\/p>\n

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For a study, researchers examined if natural human papillomavirus (HPV) infection would cause an anamnestic reaction to quadrivalent (qHPV) immunization in women with SLE (SLE). Thirty-four women (19-50 years) with mild to moderate SLE that was either minimally active or inactive were given the usual qHPV vaccination. The HPV competitive Luminex Immunoassay was used to assess neutralizing antibody titers to HPV 6, 11, 16, and 18. Logistic regressions were run for each HPV type to investigate the link between a positive titer at baseline and their final geometric mean titer and the growth in the titer. The Fisher\u2019s Exact Test was performed to examine the relationship between at least one positive HPV antibody test at baseline and a history of abnormal pap smears.<\/p>\n<\/div>\n<\/div>\n

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In 52.9% of cases, there was a history of abnormal pap smear\/cervical neoplasia. At baseline, anti-HPV antibody titers at baseline: 21% were negative for all four HPV types, whereas 79% were positive for one of the four HPV types. Statistical analysis revealed that those with a history of abnormal pap smears\/cervical neoplasia were more likely to have a positive anti-HPV antibody result before vaccination to one of the four kinds, (P<\/i>\u00a0= 0.035) Fisher\u2019s Exact Test. In general, HPV-exposed women had greater post-vaccine GMTs and higher point estimates than HPV unexposed women. There was no indication of an anamnestic response when the rise in titers was examined using logistic regression.\u00a0Prior HPV infection and cervical neoplasia in SLE had been associated with a lack of anamnestic response to the HPV vaccination. This validated the decision not to screen for HPV antibodies before vaccination.<\/p>\n

Original Article<\/a><\/div>\n
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The Impact Of A Prior HPV Infection Or A History Of Abnormal Pap Smear On The Humoral Immune Response To A Quadrivalent Human Papillomavirus (qHPV) Vaccination For a study, researchers examined if natural human papillomavirus (HPV) infection would cause an anamnestic reaction to quadrivalent (qHPV) immunization in women with SLE (SLE). Thirty-four women (19-50 years) […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_metasync_otto_title":"","_metasync_otto_description":"","_metasync_otto_keywords":"oral cancer detection, HPV vaccination, abnormal Pap smear, HPV infections, immune response, oral cancer awareness, HPV-related health issues, cancer prevention strategies","_metasync_otto_og_title":"Abnormal Pap Smears: Impact on HPV Vaccine Response","_metasync_otto_og_description":"Learn how prior HPV infections & abnormal Pap smears impact qHPV vaccine response.","_metasync_otto_twitter_title":"HPV & Pap Smears: Impact on Oral Cancer Prevention #VELscope","_metasync_otto_twitter_description":"HPV vaccine response impacted by prior infections or abnormal Pap smears. Understand the connection #HPV #VaccineResponse","rank_math_title":"","rank_math_description":"","_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"The Impact Of A Prior HPV Infection Or A History Of Abnormal Pap Smear On The Humoral Immune Response linked to HPV.","_aioseo_title":"","_aioseo_description":"","_metasync_seo_title":"","_metasync_seo_desc":"","_metasync_otto_disabled":"","footnotes":""},"categories":[119,124],"tags":[135,130],"class_list":["post-177130","post","type-post","status-publish","format-standard","hentry","category-oral-cancer","category-velscope","tag-abnormal-pap","tag-hpv"],"_links":{"self":[{"href":"https:\/\/velscope.com\/wp-json\/wp\/v2\/posts\/177130","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/velscope.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/velscope.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/velscope.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/velscope.com\/wp-json\/wp\/v2\/comments?post=177130"}],"version-history":[{"count":0,"href":"https:\/\/velscope.com\/wp-json\/wp\/v2\/posts\/177130\/revisions"}],"wp:attachment":[{"href":"https:\/\/velscope.com\/wp-json\/wp\/v2\/media?parent=177130"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/velscope.com\/wp-json\/wp\/v2\/categories?post=177130"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/velscope.com\/wp-json\/wp\/v2\/tags?post=177130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}