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Baran Lab
@BaranLabReads
Electrifying chemistry...
La Jolla, CA
baranlab.org
Joined January 2014
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    Baran Lab
    @BaranLabReads
    Jun 4
    Final version of this work has appeared today in @ScienceMagazine :
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    Baran Lab
    @BaranLabReads
    Jan 22
    Article cover image
    Stereoretentive Radical-Radical Cross-Coupling
    Forming chiral C(sp³)–C(sp³) linkages via cross-coupling poses significant hurdles in organic chemistry, stemming from issues like β-hydride elimination, selectivity between homo- and heterocoupling,...
    science.org
    Stereoretentive radical-based alkyl-alkyl cross-coupling
    The construction of stereogenic C(sp3)–C(sp3) bonds through cross-coupling remains a formidable challenge owing to competing β-hydride elimination and homocoupling as well as the poor inherent...
    29K
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    Baran Lab
    @BaranLabReads
    Jun 6, 2020
    A message to the @scrippsresearch chemistry community from @DonnaBlackmond and Phil regarding the @angew_chem essay posted here for anyone interested on Openflask: openflask.blogspot.com/2020/06/messag…
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    Baran Lab
    @BaranLabReads
    Mar 14, 2025
    🚨RADICAL RETHINK: STEREORETENTIVE CROSS COUPLING UNLOCKED🚨 Today in @ChemRxiv (chemrxiv.org/engage/chemrxi…) the first method for stereoretentive radical cross-coupling is disclosed. No fancy ligands or redox needed—just a Ni-diazene twist. 120 years after Gomberg, a new chapter
    198K
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    Baran Lab
    @BaranLabReads
    Apr 3, 2020
    Can total synthesis provide a viable blueprint for a med. chem. exploration of Taxol in the absence of semi-synthesis? Like proving an obscure mathematical theorem, thats the fundamental q. we set out to answer >13 years ago. Appearing now on @ChemRxiv : bit.ly/2UWP7Bz
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    Baran Lab
    @BaranLabReads
    Nov 16, 2020
    DEAR JOURNALS THAT CHARGE THOUSANDS FOR COLOR GRAPHICS: 1980 CALLED AND WOULD LIKE THEIR POLICY BACK. Sincerely, Scientists and taxpayers
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    Baran Lab
    @BaranLabReads
    Apr 9, 2020
    Several folks have requested that Heterocycles Classes be made available on YouTube (they are already on iTunes U). Here is a link to the 19 lectures from 2019 as well as all lecture handouts in the ensuing tweets:
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    Baran Lab
    @BaranLabReads
    Nov 11, 2024
    Finally, RADICAL CROSS COUPLING without the exogenous REDOX. We disclose in @ChemRxiv (chemrxiv.org/engage/chemrxi…) a broadly general platform for achieving transformations that normally required excess metallic or chemical reducing agents or photochemical setups (and their
    171K
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    Baran Lab
    @BaranLabReads
    Dec 30, 2021
    Presenting an electrifying C–C bond forming method that can drastically shorten the routes to a myriad of structures, appearing today in @ChemRxiv (bit.ly/3sSCzxw).
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    Baran Lab
    @BaranLabReads
    Jan 19, 2023
    Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed
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    Baran Lab
    @BaranLabReads
    Feb 7, 2022
    Electroaffinity labeling: a powerful new tool for target identification and Chemical Biology. Appearing today in @ChemRxiv, a collaboration with brilliant @Merck scientists: bit.ly/3B5eSEv
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    Baran Lab
    @BaranLabReads
    Jul 20, 2020
    TAGETITOXIN! With only one of its 11 carbons without a heteroatom attached, its probably the most polar organic compound we have ever made... A total synthesis, Just Accepted @J_A_C_S: bit.ly/32CQpqI Behind-the-scenes: bit.ly/3hjEAtG
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    Baran Lab
    @BaranLabReads
    Jan 22, 2021
    We finished some natural product total syntheses from 2016-2020. Here’s why we did it, what we learned, and an analysis of how far we have to go: pubs.acs.org/doi/pdf/10.102…
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    Baran Lab
    @BaranLabReads
    Dec 20, 2023
    Degrade proteins, not your work schedule! A new method appearing today @ChemRxiv (chemrxiv.org/engage/chemrxi…) simplifies access to molecular glues (like PROTACS) to save medicinal chemists valuable time. One-step access from cheap commercial materials, a trivial experimental setup,
    65K
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    Baran Lab
    @BaranLabReads
    Mar 22, 2023
    The 2023 edition of Heterocycles is coming on April 3 (see attached syllabus)! This year will be a reverse classroom format wherein new material will be discussed with problem solving sessions including real-world consulting questions. Please review the books.apple.com/us/book/the-po…
    59K