Professor researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own. @joinlifespan
Firstly, Dan Gottschling is a legend, having discovered yeast epigenetic gene silencing at the gender genes (a/alpha), telomeres, and painfully scooped me as a postdoc in 1996 by publishing epigenetic silencing at the ribosomal DNA (rDNA) 😆 ... 
While limited to mouse models, these findings add to a growing body of evidence that rejuvenation by epigenetic reprogramming may safely reverse aging-related decline in multiple tissues, or whole body one day 
In the United States alone, about 1 in 5 deaths is due to cardiovascular disease. That’s roughly 700K-900K deaths per year. Globally, cardiovascular disease causes nearly 20 million deaths annually
In the tumor microenvironment (TME), there was increased isoleucine processing and intracellular acetyl-coA, along with increase expression of genes involved in the starvation response, autophagy
Heres the formula: 𝐶𝑎𝑟𝑑𝑖𝑜𝑀𝑒𝑡𝐴𝑔𝑒𝑃𝑟𝑒𝑑𝑖𝑐𝑡 = 0.831320 × 𝑎𝑔𝑒 + 19.5734 × log( 𝐻𝑏𝐴1𝑐 + 1) + 1.77394 × 𝑅𝐷𝑊 + 0.0760217 × 𝑆𝐵𝑃 + 6.18803 × 𝑐𝑟𝑒𝑎𝑡𝑖𝑛𝑖𝑛𝑒 − 0.148076 × 𝑙𝑦𝑚𝑝ℎ𝑜𝑐𝑦𝑡𝑒 𝑝𝑒𝑟𝑐𝑒𝑛𝑡 + 0.218946 × 𝑀𝐶𝑉 + 0.105980 × 𝑝𝑢𝑙𝑠𝑒 𝑟𝑎𝑡𝑒 + 0.0603608 × 𝑃𝑃 + 0.636711 × 𝑈𝐴 + 2.40001 × log( 𝐶𝑅𝑃 + 1) + 0.0283277 × 𝑊𝐶 + 0.0754119 × 𝐵𝑈𝑁 − 101.454
Firstly, hypobaric (low) pressure should not to be confused with hyper-baric oxygen therapy (HBOT), which is also studied by longevity researchers, though there may be overlapping hormetic mechanisms between the two @NaturePortfolio
Around 5–5.7% of adults worldwide experience depressive disorders at any given time. >280 million people! 
CBD, or cannabidiol, is the second most prevalent active ingredient in marijuana, with no effects indicative of any abuse or dependence potential
In 2008, we showed movement of the NAD-dependent enzyme SIRT1 away from regulated genes to DNA breaks (which happen every day in every cell) is a key process in the loss of epigenetic information that we have proposed leads to aging and diseases 
Background: DNA methylation (DNAme) is a chemical modification of DNA on the "Cs" in DNA, which changes over time, the rate of which depends on how healthy you live over the course of your life... ⏰ 
Various mitochondrial stressors, such as pathogen infection and metabolic deficiencies, trigger the release of mtDNA into the cytosol and an inflammatory response, but why? 
L-theanine is known to reduce inflammation, stress and anxiety, among other effects. It is primarily found in tea leaves, especially green & black. Also in supplements. Common doses are 100 - 400 mg/d 
1. Labeling aging a disease could fuel ageism. Employers already assume older adults are less capable. The “disease” label may reinforce stereotypes and discrimination
Link to paper by Dr. Adiv Johnson link.springer.com/article/10.100…
This news is strong evidence that the original vision to develop therapies that reversal of aging to prevent and cure diseases of aging and injuries isn’t just a fanciful idea
The DunedinPACE aging measure was designed to assess the pace of aging by using 20 years of longitudinal measurements of 19 different biomarkers
A decline in hepatic NAD+ levels due to ethanol exposure is recognized as a key contributor to alcoholic liver injury
Over 180 mushroom species contain psilocybin, including Psilocybe cubensis, Psilocybe semilanceata (Liberty caps), and others 