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The PPI-Sepsis study is a mistake we must never repeat
The world's first translational review discussing the causal assumptions.
Sep 12, 2025
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Rafael Olivé Leite
10
8
6
Thresholds-based definitions introduced bias into critical care research
A short paper
Aug 30, 2025
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Rafael Olivé Leite
14
9
5
Spotify link!
Why Critical Care research Keeps Failing?
Jan 12
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Rafael Olivé Leite
2
Most Popular
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How do we mistake biological plausibility for clinical relevance?
Apr 27, 2024
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Rafael Olivé Leite
69
15
30
Prof. Vincent never got it right
Nov 30, 2024
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Rafael Olivé Leite
21
34
9
Maestro Gattinoni knew it
Jan 4, 2025
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Rafael Olivé Leite
16
5
Slutsky doesn't grasp Gattinoni's legacy
Jan 18, 2025
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Rafael Olivé Leite
13
1
12
The Flag of Permanent Defeat
Nov 8, 2024
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Rafael Olivé Leite
13
2
9
Exhaustion
Apr 1, 2025
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Rafael Olivé Leite
11
4
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Why Critical Care Research Keeps Failing?
The case for marginal utility
Jan 10
•
Rafael Olivé Leite
1
2
2
32:22
SOFA-2: Wild & Wrong
Open your eyes wide when you see a study using SOFA as an outcome
Jan 3
•
Rafael Olivé Leite
8
5
SOFA-2: A Commitment to Failure
The updated score is a revival of fruitless decades-old ideas. Does it have a future?
Dec 28, 2025
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Rafael Olivé Leite
6
1
4
The Flag of Permanent Defeat
Epistemic Crisis and Failure in Sepsis Research
Nov 1, 2025
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Rafael Olivé Leite
3
3
Can we drive immunity back into homeostasis?
The guys from TIGRIS think we can.
Oct 27, 2025
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Rafael Olivé Leite
8
2
Precision Critical Care?
Don't mistake P-fishing for precision medicine.
Oct 14, 2025
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Rafael Olivé Leite
4
3
1
Marik and the rise of Alternative Critical Care
Academic critical care is becoming indistinguishable from alternative medicine
Sep 22, 2025
•
Rafael Olivé Leite
10
5
5
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The Thoughtful Intensivist
Insightful criticism of current critical care research
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