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Talk Python To Me

A podcast on Python and related technologies


#1
Python Podcast
11+
Years Running
50M+
Downloads

Latest episode: #546 Self hosting apps for Python people

The cloud is convenient until it isn't. You upload your photos, sync your contacts, click through the cookie banners. Then prices go up again or you read about a family that lost their entire Google account over a medical photo sent to a doctor. At some point, the question shifts from "why would I run this myself?" to "why aren't I?"

My guest this week is Alex Kretzschmar, head of DevRel at Tailscale, longtime host of the Self-Hosted podcast, and co-founder of Linuxserver.io. We cover what self-hosting really means in 2026, the apps worth running yourself like Immich and Home Assistant, why Docker Compose ties it all together, and how Tailscale lets you reach any of it from anywhere, without opening a single port. If you've been thinking about pulling your digital life back behind your own walls, this is your roadmap.

Upcoming episodes

Panelists
Panelists
(up next)
Parallel Python at Any Scale with Ray

Chris May
Chris May
(and then)
Event Sourcing Design Pattern

Michael Booth
Michael Booth
(finally)
Hyper-Personal Software with Python

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Python for Production

Learn how to build, deploy, and scale production-ready Python applications. From best practices to real-world patterns, this book covers everything you need to take your Python projects from prototype to production.

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Python Bytes Podcast

Do you enjoy Talk Python To Me? We created a second podcast to be the perfect counterpart to the long-form interview format.

Python Bytes delivers Python headlines directly to your earbuds in just 15-20 minutes per week. The topical items of the Python ecosystem, condensed and ready to go.

Michael Kennedy
Michael Kennedy
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About the Show

Talk Python to Me is a weekly podcast covering a wide array of Python topics as well as many related technologies. Each episode features a casual 1-hour conversation with industry experts.

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