Lu Li

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Email luli1[at]sas.upenn.edu

I am a fifth year PhD student in the Applied Math and Computational Science (AMCS) program at University of Pennsylvania, where I’m fortunate to be advised by Prof. Yong Chen. Previously, I received a B.A. in Mathematics (Honors) and Computer Science from Macalester College, where I was forturnate to work with Prof. Lori Ziegelmeier, Prof. Shilad Sen, and advised by Prof. Andrew Beveridge and Prof. Susan Fox.

My research focuses on real-world evidence (RWE) generation and evidence synthesis using real-world data (RWD), and machine learning for health.

News

Jun 16, 2025 I started my internship at Adobe Research.
Aug 23, 2021 I started my PhD at UPenn.
May 28, 2017 I graduated from Macalester College.

Selected publications
* indicates equal contribution

Clinical Evidence Generation Using Real-world Data
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    LATTE: A One-shot Lossless Algorithm for Federated Target Trial Emulation with Application to Alzheimer’s Disease and Related Dementia Drug Repurposing Using Decentralized Data
    Lu Li, Qiong Wu, Yiwen Lu, Kyra S. O’Brien, Bingyu Zhang, Ting Zhou, Jiayi Tong, Dazheng Zhang, Yuqing Lei, Huilin Tang, Haoyang Li, and 15 more authors
    the Lancet Digital Health (Invited Revision) (Impact Factor: 24.1), Oct 2025
    Selected as lightning talk at OHDSI 2025 Symposium 🏆
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    Kidney Function Following COVID-19 in Children and Adolescents
    Lu Li, Ting Zhou, Yiwen Lu, Jiajie Chen, Yuqing Lei, Qiong Wu, Jonathan Arnold, Michael J. Becich, Yuriy Bisyuk, Saul Blecker, Elizabeth Chrischilles, and 26 more authors
    JAMA Network Open (Impact Factor: 10.5), Apr 2025
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    COLA-GLM: collaborative one-shot and lossless algorithms of generalized linear models for decentralized observational healthcare data
    Qiong Wu, Jenna M Reps, Lu Li, Bingyu Zhang, Yiwen Lu, Jiayi Tong, Dazheng Zhang, Thomas Lumley, Milou T Brand, Mui Van Zandt, and  others
    npj Digital Medicine (Impact Factor: 15.1), Apr 2025
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    Telemedicine Utilization Trajectories and Sociodemographic Differences, 2019-2024
    Bingyu Zhang, Lu Li, Yiwen Lu, Jingchuan Guo, Jiang Bian, John B Salmon, Robert L Stetson, Michael A Horst, Srinivas K Sridhara, Mitchell D Schnall, and  others
    medRxiv, Apr 2025
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    Unlocking efficiency in real-world collaborative studies: a multi-site international study with one-shot lossless GLMM algorithm
    Jiayi Tong, Jenna M Reps, Chongliang Luo, Yiwen Lu, Lu Li, Juan Manuel Ramirez-Anguita, Milou T Brand, Scott L DuVall, Thomas Falconer, Alex Mayer Fuentes, and  others
    npj Digital Medicine (Impact Factor: 15.1), Apr 2025
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    ZIBGLMM: Zero-inflated bivariate generalized linear mixed model for meta-analysis with double-zero-event studies
    Lu Li, Lifeng Lin, Joseph C. Cappelleri, Haitao Chu, and Yong Chen
    Research Synthesis Methods (Impact Factor 6.1), Apr 2025
    Selected as lightning talk at OHDSI 2023 Symposium 🏆
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    Advancing Interpretable Regression Analysis for Binary Data: A Novel Distributed Algorithm Approach
    Jiayi Tong*, Lu Li*, Jenna Marie Reps, Vitaly Lorman, Naimin Jing, Mackenzie Edmondson, Xiwei Lou, Ravi Jhaveri, Kelly J Kelleher, Nathan M Pajor, and  others
    Statistics in Medicine, Apr 2024
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    Pediatric Gastrointestinal Tract Outcomes During the Postacute Phase of COVID-19
    Dazheng Zhang, Ronen Stein, Yiwen Lu, Ting Zhou, Yuqing Lei, Lu Li, Jiajie Chen, Jonathan Arnold, Michael J. Becich, Elizabeth A. Chrischilles, Cynthia H. Chuang, and 18 more authors
    JAMA Network Open (Impact Factor: 10.5), Feb 2025
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    Real-world effectiveness of BNT162b2 against infection and severe diseases in children and adolescents
    Qiong Wu, Jiayi Tong, Bingyu Zhang, Dazheng Zhang, Jiajie Chen, Yuqing Lei, Yiwen Lu, Yudong Wang, Lu Li, Yishan Shen, and  others
    Annals of Internal Medicine (Impact Factor 15.3), Feb 2024
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    Risk of neuropsychiatric and related conditions associated with SARS-CoV-2 infection: a difference-in-differences analysis
    Yiwen Lu, Jiayi Tong, Dazheng Zhang, Jiajie Chen, Lu Li, Yuqing Lei, Ting Zhou, Leyna V Aragon, Michael J Becich, Saul Blecker, and  others
    Nature communications (Impact Factor: 15.7), Feb 2025
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    Body Mass Index and Postacute Sequelae of SARS-CoV-2 Infection in Children and Young Adults
    Ting Zhou, Bingyu Zhang, Dazheng Zhang, Qiong Wu, Jiajie Chen, Lu Li, Yiwen Lu, Michael J Becich, Saul Blecker, Nymisha Chilukuri, and  others
    JAMA network open (Impact Factor: 10.5), Feb 2024
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AI / AI for Health
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    MAP: Low-compute Model Merging with Amortized Pareto Fronts via Quadratic Approximation
    Lu Li*, Tianyu Zhang*, Zhiqi Bu*, Suyuchen Wang, Huan He, Jie Fu, Yonghui Wu, Jiang Bian, Yong Chen, and Yoshua Bengio
    In International Conference on Representation Learning , 2025
    arXiv PDF Video Code Poster
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    Empowering Clinical Trial Design through AI: A Randomized Evaluation of PowerGPT
    Yiwen Lu, Lu Li, Dazheng Zhang, Xinyao Jian, Tingyin Wang, Siqi Chen, Yuqing Lei, Jiayi Tong, Zhaohan Xi, Haitao Chu, and  others
    arXiv preprint arXiv:2509.12471, 2025
Scientific Papers
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    Develop and validate a computable phenotype for the identification of Alzheimer’s disease patients using electronic health record data
    Xing He, Ruoqi Wei, Yu Huang, Zhaoyi Chen, Tianchen Lyu, Sarah Bost, Jiayi Tong, Lu Li, Yujia Zhou, Zhao Li, Jingchuan Guo, and 10 more authors
    Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2024
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    Association between risk of Alzheimer’s disease and related dementias and angiotensin receptor II blockers treatment for individuals with hypertension in high-volume claims data
    Sori Kim Lundin, Xinyue Hu, Jingna Feng, Karl Kristian Lundin, Lu Li, Yong Chen, Paul Ernest Schulz, and Cui Tao
    EBioMedicine, 2024
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