You can use wrapcolumn= in HtmlDiff
import difflib
import webbrowser
d = difflib.HtmlDiff(wrapcolumn=10)
lines1 = ['aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa']
lines2 = ['XXXXXXXXXXXXXaaaaaaaaaYYYaaaaaaZZZZZZZZZZZaaaaZZZZZZZZ']
html = d.make_file(lines1, lines2)
with open('output.html', 'w') as fh:
fh.write(html)
webbrowser.open('output.html')
Without wrapcolumn=

With wrapcolumn=10

EDIT:
I didn't test it but in source code of diff you can see hidden variables _styles, _table_template, _file_template which you could replace in HtmlDiff to generate different HTML. This way you could add classes and styles to format it.
It may also need to change hidden _format_line to remove nowrap="nowrap"
EDIT:
I use HtmlDiff to create own class with new _format_line() without nowrap="nowrap" and now I can add styles with width and word-break
import difflib
import webbrowser
# --- classes ---
class MyHTML(difflib.HtmlDiff):
def __init__(self, *args, **kwargs):
super().__init__(*args, **kwargs)
# append new styles inside new class
self._styles = self._styles + """
table.diff {width: 300px}
.diff_sub {display: inline-block; word-break: break-word;}
.diff_add {display: inline-block; word-break: break-word;}
"""
# function from source code - I remove only `nowrap="nowrap"`
def _format_line(self,side,flag,linenum,text):
"""Returns HTML markup of "from" / "to" text lines
side -- 0 or 1 indicating "from" or "to" text
flag -- indicates if difference on line
linenum -- line number (used for line number column)
text -- line text to be marked up
"""
try:
linenum = '%d' % linenum
id = ' id="%s%s"' % (self._prefix[side],linenum)
except TypeError:
# handle blank lines where linenum is '>' or ''
id = ''
# replace those things that would get confused with HTML symbols
text=text.replace("&","&").replace(">",">").replace("<","<")
# make space non-breakable so they don't get compressed or line wrapped
text = text.replace(' ',' ').rstrip()
return '<td class="diff_header"%s>%s</td><td>%s</td>' \
% (id,linenum,text)
# --- main ---
d = MyHTML()
# >>> changing styles after creating `MyHTML` or in original `HtmlDiff <<<
#d._styles = d._styles + """
#table.diff {width: 300px}
#.diff_sub {display: inline-block; word-break: break-word;}
#.diff_add {display: inline-block; word-break: break-word;}
#"""
#d._file_template = """new template"""
lines1 = ['aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa']
lines2 = ['XXXXXXXXXXXXXaaaaaaaaaYYYaaaaaaZZZZZZZZZZZaaaaZZZZZZZZ']
html = d.make_file(lines1, lines2)
with open('output.html', 'w') as fh:
fh.write(html)
webbrowser.open('output.html')
Shorter version
import difflib
import webbrowser
d = HtmlDiff(wrapcolumn=10)
d._file_template = """new template with %(charset)s %(styles)s %(table)s %(legend)s"""
#d._styles = """new styles"""
lines1 = ['aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa']
lines2 = ['XXXXXXXXXXXXXaaaaaaaaaYYYaaaaaaZZZZZZZZZZZaaaaZZZZZZZZ']
html = d.make_file(lines1, lines2)
with open('output.html', 'w') as fh:
fh.write(html)
webbrowser.open('output.html')
_stylesand_templatewhich you could use to assign own styles and own HTML template. Besides there iswrapcolumnin classHtmlDiffwhich could help to make it shorter.