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SoftWave Research

Newest Research

Click to access Science Compendium List 2024_02_02
European Heart Journal
Sticky Post

SoftWave TRT Affiliate Study Featured in Prominent Medical Journal

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Erectile Dysfunction and the Shocking Truth: Is Shockwave Therapy Effective

softwave device with water water blue background

What are the Side Effects of SoftWave Therapy

Extracorporeal shock wave therapy for calcifying tendinitis of the shoulder

The beneficial effects of in vitro shock wave treatment on cardiomyogenesis are energy dependent

Orthospec Shockwave System Clinical Uses, Evidence, and Limitations

Orthospec ESWT System Explained

Efficacy and safety of extracorporeal shock wave therapy for acute and chronic soft tissue wounds: A systematic review and meta-analysis

Athletic therapy (Mts-Science)

Effects of Extracorporeal Shockwave Therapy on Patients with Chronic Low Back Pain and Their Dynamic Balance Ability

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Chronic Tendonitis Treatment When Injections Have Failed

Chronic Tendonitis Treatment When Injections Have Failed

Dr Irwin Goldstein Dinner Presentation – Nashville

Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure

Effects of Shock Waves on Expression of IL-6, IL-8, MCP-1, and TNF- alpha Expression by Human Periodontal Ligament Fibroblasts: An In Vitro Study

SDSM Spine pain protocol

Extracorporeal shockwave therapy (ESWT) First choice treatment of fracture non-unions?

Extrakoprorale Stoßwellentherapie am Knochen – Voodoo oder Therapieoption?

​Shock waves for arthritis A new form of therapy offers pain relief using sound waves in pets

The Basic Science Behind Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction

Shock wave therapy for acute and chronic soft tissue wounds: A feasibilty study

The link between shockwaves and innate immunity – the main working mechanism?

Is surgery the only option for bone-on-bone?

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Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study

OmniWave Shockwave Therapy- Efficacy & Alternatives Explained

OmniWave Shockwave Therapy: Efficacy & Alternatives Explained

Serum Proteomic Analysis of Extracorporeal Shock Wave Therapy–Enhanced Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Model

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Stem cells pose risk, offer promise

Technology Assessment “Wound Care” dermagold100

4 U. S. Patents issued on July 19, 2022

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Shock wave treatment for in vitro engineering applications

The Biologic Effects of SoftWaves™and Rationale for Spine and Brain Therapy

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Renova Shockwave Therapy- What Is It & Does It Work for Patients?

Renova Shockwave Therapy: What Is It & Does It Work for Patients?

The influence of comorbidities and etiologies on the success of extracorporeal shock wave therapy for chronic soft tissue wounds: midterm results.

Alteration Of Inflammatory Response By Shock Wave Therapy Leads To Reduced Calcification Of Decellularized Aortic Xenografts In Mice.

Treatment of stress urinary incontinence

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Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

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Alternative Treatment using Shockwave for Erectile Dysfunction

Prospective Randomized Trial of Accelerated Re-Epithelization of Skin Graft Donor Sites Using Extracorporeal Shock Wave Therapy

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Adhesive Capsulitis Management with Advanced Shockwave Therapy

SoftWave: Empowering Adhesive Capsulitis Management with Advanced Shockwave Therapy

Biological Principles – Mechanotransduction

ESWT in skin & aesthetic indications

EPAT Therapy Side Effects & Contraindications

​Cell biological effects of mechanical stimulations generated by focused extracorporeal shock wave applications on cultured human bone marrow stromal cells

Optimization of screw fixation in rat bone with extracorporeal shock waves

Regenerative Restorative Care Treatments Post Knee Surgery

Regenerative Restorative Care Treatments Post Knee Surgery

The Use of Shock Waves in Peripheral Nerve Regeneration:New Perspectives?

Knee Pain Relief through Advanced Shockwave Therapy

SoftWave: Leading the Way in Knee Pain Relief through Advanced Shockwave Therapy

Shock waves promote spinal cord repair via TLR3

Regenerative Treatments in Sports and Orthopedic Medicine for Clinicians in 2025

Regenerative Treatments in Sports and Orthopedic Medicine for Clinicians in 2025

Letter regarding non unions in Europe. Dr. Schaden managing Director of the Workman’s Compensation Insurance Organization in Austria

Prof. M. Kravchik. Focused shockwave therapy in the treatment of the spine. Oxford, UK Non-invasive treatment of herniated discs by focused shock wave therapy

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Effect of Extracorporeal Shockwave Therapy (ESWT) on Pulpal Blood Flow After Orthodontic Treatment: A Randomized Clinical Trial

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EPAT Shockwave Therapy Efficacy & Alternatives Explained

What Is EPAT Therapy & How Does It Work?

Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

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Zapping chronic tendon pain

​Exosomes and Cardiovascular Protection

A study to identify the potential effects of extracorporeal shockwave therapy alone and in combination with Avastin.

Elucidating the molecular mechanisms underlying cardiac shock wave therapy

MTS Spark Waves®– an effective therapy option for aesthetic indications Cellulite / Scars / Stretch marks / Lymphoedema / Alopecia -(MTS Science)

SoftWave vs Shockwave Technology Explained 

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Low-Energy Extracorporeal Shock Wave Ameliorates Streptozotocin Induced Diabetes and Promotes Pancreatic Beta Cells Regeneration in a Rat Model

“In vitro” and multicolor phenotypic characterization of cell subpopulations identified in fresh human adipose tissue stromal vascular fraction and in the derived mesenchymal stem cells

Extracorporeal Shock Wave Therapy (ESWT) in Acute Traumatic Complete (AIS A) and Incomplete (AIS B-D) Cross-sectional Lesions on Motor and Sensory Function Within Six Months After Injury

Extracorporeal shock waves, a new non-surgical method to treat severe burns

Relief for Back Pain with Innovative Shockwave Therapy

SoftWave ESWT: Redefining Relief for Back Pain with Innovative Shockwave Therapy

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The Role of Extracorporeal Shock Wave Therapy and Manual Lymphatic Drainage in Chronic Ulcers Treatment

SoftWave Therapy for Knees

SoftWave Therapy vs. Stem Wave & Acoustic Wave Devices for Knee Pain

The Assessment of New Bone Formation Induced by Unfocused Extracorporeal Shock Wave Therapy Applied on Pre-Surgical Phase of Distraction Osteogenesis

Optimal timing of extracorporeal shock wave treatment to protect ischemic tissue

Effective Medical Devices for Temporomandibular Joint Dysfunction

Effective Medical Devices for Temporomandibular Joint Dysfunction

Plantar Fasciitis Medical Devices That Relieve Pain

Does Dermapace Work for Patients?

Peripheral Nerve Regeneration

Peripheral Nerve Regeneration

Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Shock wave therapy enhances neuronal sprouting and improves neuronal survival

UGA In vitro study: ESWT treatment of platelets causes increased release of growth factors

Treatment for osteonecrosis of the femoral head

10 Questions Every Provider Should Ask Before Choosing a Shockwave Medical Device

10 Questions Every Provider Should Ask Before Choosing a Shockwave Medical Device

AUVA letter‒ Successful treatment of delayed and non-union fractures

Why SoftWave Is the Proven Standard in Regenerative Medicine Devices

Best Shockwave Machine for Providers

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Cellular mechanotransduction: putting all the pieces together again

Unfocused extracorporeal shockwave therapy diminishes bone loss in rats

Physical Rehabilitation Using Shockwave Therapy

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Effects of Extracorporeal Shock Wave Therapy on Spasticity in Patients after Brain Injury: A Meta-analysis

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Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery

Morton's Neuroma

Effective Medical Devices for Treating Morton’s Neuroma

Shockwave Therapy Contraindications- When Not to Use It

Shockwave Therapy Contraindications: When Not to Use It

Linear Shockwave Therapy in Clinical Practice- Evidence and Mechanisms

Linear Shockwave Therapy Mechanisms and Efficacy Explained

Innovating Plantar Fasciitis Relief with Advanced Shockwave Therapy

EPAT Therapy for Plantar Fasciitis vs Alternatives

The Roll of Spark Waves in the Management of Chronic Wounds.

​Role of extracorporeal shock wave therapy in management of Peyronie’s disease: A preliminary report

Molecular changes in diabetics foot ulcers

Gainswave Machines: Cost, Efficacy, & Alternatives

Gainswave Machines: Cost, Efficacy, & Alternatives

Biological mechanism of shockwave in bone

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The Effect of Different Doses of Extracorporeal Shock Waves on Experimental Model Mandibular Distraction

Pioneering Shoulder Pain Relief with Advanced Shockwave Therapy

SoftWave: Pioneering Shoulder Pain Relief with Advanced Shockwave Therapy

Penile low intensity shock wave therapy for PDE5i non-responders suffering from vasculogenic Erectile Dysfunction since 2 to 10 years: A prospective, randomized, placebo-controlled study

ESWT for resident stress fractures in athletes.

A neural model for chronic pain and pain relief by extracorporeal shock wave treatment

Effectiveness of extracorporeal shock wave for low back pain (A protocol of systematic review)

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What Is Pulse Wave Therapy & Does It Work for Patients?

What Is Pulse Wave Therapy & Does It Work for Patients?

How Li-ESWT Works for Patients With ED & Other Indications

Zimmer Shockwave Therapy: Cost, Efficacy, and Alternatives

Extracorporeal Shock-Wave Therapy Compared with Surgery for Hypertrophic Long-Bone Nonunions

Low-energy extracorporeal shock wave therapy for a model of liver cirrhosis ameliorates liver fibrosis and liver function

Extracorporeal shockwave therapy (ESWT) e First choice treatment of fracture non-unions?

Extracorporeal shockwave therapy (ESWT) minimizes ischemic tissue necrosis irrespective of application time and promotes tissue revascularization by stimulating angiogenesis

ESWT for Acute and Chronic Soft Tissue Wounds

Comparing Shockwave Therapy Machine Costs

Shockwave + Biologic Regeneration: Two Paths to Healing, One Goal

First Report for Unfocused Low Intensity SoftWave® Therapy (uESWT ) for Nocturia and Erectile Dysfunction (ED)

Efficacy and safety of extracorporeal shock wave therapy for orthopedic conditions: a systematic review on studies listed in the PEDro database

Shock Wave Treatment Protects From Neuronal Degeneration via a Toll-Like Receptor 3 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury

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Influence of extracorporeal shock wave therapy (ESWT) on bone turnover markers in organisms with normal and low bone mineral density during fracture healing: a randomized clinical trial

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Low Intensity Shock Wave Treatment for Erectile Dysfunction-How Long Does the Effect Last?

DolorClast Therapy- Mechanism, Indications, and Clinical Evidence

DolorClast Therapy: What Is It & Does It Work for Patients?

LL37 and shock waves

Molecular and Cellular Effects of In Vitro Shockwave Treatment on Lymphatic Endothelial Cells

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Doubts over heart stem-cell therapy

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Biological mechanism of musculoskeletal shockwaves

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Focused Shockwave Therapy Efficacy & Alternatives

Focused Shockwave Therapy Efficacy & Alternatives

Shock waves promote spinal cord repair via TLR32

OmniWave Shockwave Machines: Efficacy & Alternatives Explained

A prospective, randomized, controlled, single centre trial to assess the efficacy and safety of radial extracorporeal shockwave therapy in patients with chronic non-specific low back pain

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Extracorporeal shockwave therapy versus exercise program in patients with low back pain: short-term results of a randomised controlled trial.

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Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease

Shock wave treatment of muscle stem cells – a new implementation for regeneration

Chattanooga Shockwave Devices Compared- What Clinicians Should Evaluate

Chattanooga Shockwave Therapy Devices Compared

Scientific Reports – Gene transfection by shock waves

Chattanooga Intelect Shockwave Machine- Evidence, Mechanisms, and Clinical Context

Chattanooga Intelect Shockwave Machine: Efficacy & Alternatives

Doctor Uses Shockwave Therapy to Heal Nearly Severed Foot

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Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia vi a Toll-like receptor 3 dependent mechanism

The Influence of Shockwave Therapy on Orthodontic Tooth Movement Induced in the Rat

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Plantar Fasciitis Medical Devices That Relieve Pain

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Shockwave Therapy vs Therapeutic Ultrasound- Differences, Benefits, and Outcomes

Shockwave Therapy vs Therapeutic Ultrasound: Differences, Benefits, and Outcomes

Extracorporeal shockwave therapy as supplemental therapy for closure of large full thickness defects – Rat full -thickness skin graft model

Effectiveness of shock wave therapy: implementation of a soft wide focus applicator in patients with erectile dysfunction

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Effects of the extracorporeal shock wave therapy on the skin: an experimental study

Original hypothesis: Extracorporeal shockwaves as a homeostatic autoimmune restorative treatment (HART) for Type 1 diabetes mellitus

Extracorporeal Shockwave Therapy for Arthritis Treatment

Body shaping with acoustic wave therapy AWT(®)/EPAT(®): randomized, controlled study on 14 subjects.

Evaluation of a low-intensity shockwave therapy for chronic prostatitis type IIIb/chronic pelvic pain syndrome: a double-blind randomized sham-controlled clinical trial

Analysis of treatment protocols: application of ESWT for wound healing disorders

Expanding Non-Surgical Treatment Options for Meniscus Injuries in Clinical Practice

Expanding Non-Surgical Treatment Options for Meniscus Injuries in Clinical Practice

Shock Wave Therapy Compared with Intramedullary Screw Fixation for Nonunion of Proximal Fifth Metatarsal Metaphyseal-Diaphyseal Fractures

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Exploring Alternatives to Pain Treatment: Your Path to Natural Relief

Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears

​Extracorporeal shock wave therapy in periodontics: A new paradigm

Spark Wave® Therapy Improves Full Thickness Skin Defects

MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a rat model of cavernous nerve injury

2025 AUA Guidelines on Male Chronic Pelvic Pain: Shockwave Therapy Evidence and Clinical Implications

Shock waves induce angiogenesis via exosome release

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Impact of Extracorporeal Shock Wave Therapy (ESWT) on Orthodontic Tooth Movement – A Randomized Clinical Trial

Extracorporeal shockwave therapy for treatment of keloid scars

opioids united states

FDA Tightens Opioid Warning Labels: Here’s the Non-Invasive Alternative Changing Pain Care

Pickleball Star Riley Newman Speeds Recovery With SoftWave Therapy

Zimmer enPulsPro Shockwave Machines-

Zimmer enPulsPro Shockwave Machines: Efficacy & Alternatives

​Spark Waves® in Neurodegenerative Diseases – Concept for the Treatment of Alzheimer’s and Parkinson’s Disease

MTS Spark WavesTM – successfully treating indispositions of the musculoskeletal system

Low-energy Extracorporeal Shock Wave Therapy (ESWT) on secondary fibrolymphedema

Using acoustic therapy to prevent opioid addiction.

​Prospective randomized phase II trial of accelerated reepithelialization

ISMST (International Society for Medical Shockwave Treatment)

Storz Masterpuls Machines: Cost, Efficacy, & Alternatives 

Shock wave therapy alone has no impact on cancer growth

Cellulite and focused extracorporeal shockwave therapy for non-invasive body contouring: a randomized trial.

Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice

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Shockwave Therapy for Achilles Tendonitis

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Minimally invasive treatment of Peyronie’s disease: evidence-based progress

Extracorporeal Shock Wave Therapy

Comparative SWT Data to Evaluate Competing Technologies in the Treatment of Penile Connective Tissue for Improved Erectile Function

Focused vs Radial Shockwave Therapy Machines Explained 

Shockwave Therapy for the Treatment of Cancer

Analysis of extracorporeal shock wave therapy for Peyronie’s disease

MTS Spark Wave Publications – Science Telegram

Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s disease

Focal Shockwave Therapy Mechanisms and Efficacy Explained

Focal Shockwave Therapy Mechanisms and Efficacy Explained

​The biologic effects of SoftWaves and rationale for spine and brain therapy

Stromal Vascular Fraction Combined with Shock Wave for the Treatment of Peyronie’s Disease

Extracorporeal shock wave therapy role in the treatment of burn patients. A systematic literature review

Spark Wave® Therapy Improves Cardiac Function

Treatment of cutaneous calcinosis in CREST syndrome by extracorporeal shockwave lithotripsy

Extracorporeal shock wave therapy (ESWT) for the treatment of spasticity in persons with spinal cord injury

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Unfocused extracorporeal shock waves induce anabolic effects in rat bone

Heart Regeneration becomes Reality!

Review of the Current Status of Low Intensity Extracorporeal Shockwave Therapy (Li-ESWT) in Erectile Dysfunction (ED)

Variable Sound-Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

Exploring Regenerative Treatment for Knees After Failed Conservative Care

Regenerative Treatment for Knees That Fail Conservative Care

Is it possible to change the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome

Effectiveness of the Electromagnetic Shock Wave Therapy in the Treatment of Cellulite

Regenerative Treatments for Athletes and Their Role Compared With Surgical Repair

Regenerative Treatments for Athletes Versus Surgical Repair

The Role of Shockwaves in the Enhancement of Bone Repair – From Basic Principles to Clinical Application

Alternatives to Back Surgery Doctors Should Consider

Alternatives to Back Surgery Doctors Should Consider

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Motor and Sensory Schwann Cell Phenotype

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Low Intensity Extracorporeal Shock Wave Therapy Improves Erectile Function in a Model of Type II Diabetes Independently of NO/cGMP Pathway

Regenerative Skin Treatment for Burns, Scars, and Wounds

Regenerative Skin Treatment for Burns, Scars, and Wounds

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Effects of ESWT on glycosaminoglycan expression during bone healing

Macrophage migration induces angiogenesis

Acoustic Field of a Ballistic Shock Wave Therapy Device

Best Medical Devices for Treating Patellar Tendinitis

Best Medical Devices for Treating Patellar Tendinitis

Mechano-transduction effect of shock waves

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MTS Science White Paper – Softwave – Pain Therapy

SoftWave’s New Leadership Team Accelerating Commercial Growth and Market Expansion

Shock wave application to cell cultures

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Biologic Response

The link between shockwaves and innate immunity – the main working mechanism?

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LL37 and shock waves

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IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)

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Biological Principles – Mechanotransduction

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Biological mechanism of musculoskeletal shockwaves

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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​The biologic effects of SoftWaves and rationale for spine and brain therapy

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IVSWT Water Bath V2.0 Manual

The number of in-vitro experiments in shock wave science increases continuously. This fact reflects how...
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​Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of...
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Shock wave application to cell cultures

Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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Shockwave treatment enhances cell proliferation and improves wound healing

Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Latest Basic Research Abstracts

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Lohse – Busch ISMST Presentation

High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration....
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Effect of shock waves on macrophages

Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

Focused high‐energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

(Johannes Holfeld, Can Tepeköylü, Radoslaw Kozaryn, Anja Urbschat, Kai Zacharowski, Michael Grimm, and Patrick Paulus)...
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Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

(​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and...
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